588 research outputs found
Abundance of Lygus spp. (Heteroptera:Miridae) in canola adjacent to forage and seed alfalfa
Our objectives were to document the abundance of lygus bugs (Miridae) in canola after the cutting of adjacent alfalfa hay fields and to document their seasonal activity in canola plots grown in close proximity to alfalfa seed. Cutting alfalfa did not increase abundance of lygus bugs in nearby canola in sites near Barrhead, Alberta (1998-1999), in the Peace River area of British Columbia (2000) or near Carman, Manitoba (2001). In Saskatoon, from 1993-1995, lygus bug numbers remained at low levels in seed alfalfa and canola and there was no indication that the pest species (L. lineolaris) in canola moved in significant numbers from the adjacent alfalfa seed field. We conclude that alfalfa forage harvesting generally does not result in massive movement of lygus bugs to nearby canola
The BioGRID Interaction Database: 2011 update
The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein
interaction data from model organisms and humans
(http://www.thebiogrid.org). BioGRID currently holds 347 966
interactions (170 162 genetic, 177 804 protein) curated from both
high-throughput data sets and individual focused studies, as derived
from over 23 000 publications in the primary literature. Complete
coverage of the entire literature is maintained for budding yeast
(Saccharomyces cerevisiae), fission yeast (Schizosaccharomyces pombe)
and thale cress (Arabidopsis thaliana), and efforts to expand curation
across multiple metazoan species are underway. The BioGRID houses 48
831 human protein interactions that have been curated from 10 247
publications. Current curation drives are focused on particular areas
of biology to enable insights into conserved networks and pathways that
are relevant to human health. The BioGRID 3.0 web interface contains
new search and display features that enable rapid queries across
multiple data types and sources. An automated Interaction Management
System (IMS) is used to prioritize, coordinate and track curation
across international sites and projects. BioGRID provides interaction
data to several model organism databases, resources such as Entrez-Gene
and other interaction meta-databases. The entire BioGRID 3.0 data
collection may be downloaded in multiple file formats, including PSI MI
XML. Source code for BioGRID 3.0 is freely available without any
restrictions
Inhibition of Ī±vĪ²5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury
Ischemia-reperfusion injury (IRI) is a leading cause of AKI. This common clinical complication lacks effective therapies and can lead to the development of CKD. The Ī±vĪ²5 integrin may have an important role in acute injury, including septic shock and acute lung injury. To examine its function in AKI, we utilized a specific function-blocking antibody to inhibit Ī±vĪ²5 in a rat model of renal IRI. Pretreatment with this anti-Ī±vĪ²5 antibody significantly reduced serum creatinine levels, diminished renal damage detected by histopathologic evaluation, and decreased levels of injury biomarkers. Notably, therapeutic treatment with the Ī±vĪ²5 antibody 8 hours after IRI also provided protection from injury. Global gene expression profiling of post-ischemic kidneys showed that Ī±vĪ²5 inhibition affected established injury markers and induced pathway alterations previously shown to be protective. Intravital imaging of post-ischemic kidneys revealed reduced vascular leak with Ī±vĪ²5 antibody treatment. Immunostaining for Ī±vĪ²5 in the kidney detected evident expression in perivascular cells, with negligible expression in the endothelium. Studies in a three-dimensional microfluidics system identified a pericyte-dependent role for Ī±vĪ²5 in modulating vascular leak. Additional studies showed Ī±vĪ²5 functions in the adhesion and migration of kidney pericytes in vitro Initial studies monitoring renal blood flow after IRI did not find significant effects with Ī±vĪ²5 inhibition; however, future studies should explore the contribution of vasomotor effects. These studies identify a role for Ī±vĪ²5 in modulating injury-induced renal vascular leak, possibly through effects on pericyte adhesion and migration, and reveal Ī±vĪ²5 inhibition as a promising therapeutic strategy for AKI
Double-beta decay of Te to the first 0 excited state of Xe with CUORICINO
The CUORICINO experiment was an array of 62 TeO single-crystal
bolometers with a total Te mass of kg. The experiment finished
in 2008 after more than 3 years of active operating time. Searches for both
and double-beta decay to the first excited state in
Xe were performed by studying different coincidence scenarios. The
analysis was based on data representing a total exposure of
N(Te)t=y. No evidence for a signal was
found. The resulting lower limits on the half lives are y (90% C.L.), and
y (90%
C.L.).Comment: 6 pages, 4 figure
A simple radionuclide-driven single-ion source
We describe a source capable of producing single barium ions through nuclear
recoils in radioactive decay. The source is fabricated by electroplating 148Gd
onto a silicon {\alpha}-particle detector and vapor depositing a layer of BaF2
over it. 144Sm recoils from the alpha decay of 148Gd are used to dislodge Ba+
ions from the BaF2 layer and emit them in the surrounding environment. The
simultaneous detection of an {\alpha} particle in the substrate detector allows
for tagging of the nuclear decay and of the Ba+ emission. The source is simple,
durable, and can be manipulated and used in different environments. We discuss
the fabrication process, which can be easily adapted to emit most other
chemical species, and the performance of the source
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