An investigation of the pressaccidic spike potential

A large negative spike potential, which is closely related to the onset of saccadic eyemovements, can be recorded from electrodes adjacent to the orbits. This potential, thepresaccadic spike potential, has often been regarded as an artefact related to eyemovement recordings and little work has been performed to establish its normal waveformand parameters. A positive spike potential, exactly coincident with the frontal negativespike, has also been recorded from electrodes positioned over the posterior scalp andthere has been some debate regarding any possible relationship between the twopotentials. The frontal spike potential has been associated with motor unit activity in theextraocular muscles prior to the saccade. This thesis investigates both the large anteriorand smaller posterior spike potentials and relates these recordings to the saccadic eyemovements associated with them. The anterior spike potential has been recorded from normal subjects to ascertain its normallatency and amplitude parameters for both horizontal and vertical saccades. A relationshipbetween saccade size and spike potential amplitude is described, the spike potentialamplitude reducing with smaller saccades. The potential amplitude also reduces withadvancing age. Studying the topographical distribution of the spike potential across thescalp shows the posterior spike activity may arise from potential spread of the larger frontalspike potential. Spike potential recordings from subjects with anomalous eye movements further implicate the extraocular muscles and their innervation in the generation of the spike potential. These recordings indicate that the spike potential may have some use as a clinical recording from patients with disease conditions affecting either their extraocular muscles or the innervational pathways to these muscles. Further recordings of the potential are necessary, however, to determine the exact nature of the changes which may occur with such conditions

Procedural feature generation for volumetric terrains

© 2017 Copyright held by the owner/author(s). In this work we present separate procedural methods to generate features that are found in natural terrains which are difficult to reproduce with heightmap-based methods. We approximate overhangs, arches and caves using procedural functions and a reduced set of parameters. This produces visually plausible terrain feature topologies as well as a high degree of artistic control. Our approach is more intuitive and art-directable than other existing volumetric methods that are more complex to integrate into existing voxel engines, due to the framework changes necessary, or rely on automatic procedural generation, thus reducing the ability to provide creative input

Factors influencing the relationship between the dose of amlodipine required for blood pressure control and change in blood pressure in hypertensive cats

BACKGROUND: Hypertension is a common problem in elderly cats. In most cats, systolic blood pressure (SBP) of <160 mmHg is achieved in response to amlodipine besylate at either 0.625 or 1.25 mg q24h. The individual cat factors determining dose requirement dose have not been explored. AIMS: To determine whether individual cat factors influence the dose of amlodipine required to achieve adequate blood pressure control and to determine whether factors other than the prescribed dose of drug alter the achieved plasma amlodipine concentrations. METHODS: Fifty‐nine hypertensive cats that required 0.625 mg (A) and 41 cats that required 1.25 mg (B) amlodipine to reach a target SBP of <160 mmHg were identified, and plasma amlodipine concentrations were determined. Comparisons were made between groups, and multivariable linear regression models were performed to investigate predictors of antihypertensive response. RESULTS: Cats that required a greater dose of amlodipine had significantly higher SBP at diagnosis of hypertension (A: (median [25th, 75th percentile]) 182 [175,192] mmHg; B: 207 [194,217] mmHg, P < .001), but comparable blood pressure was achieved after treatment. Plasma amlodipine concentrations were directly related to the dose of amlodipine administered. At diagnosis, cats in group B had significantly lower plasma potassium concentration (A: 4.1 [3.8,4.5]; B: 3.8 [3.6,4.2] mEq/L, P < .01). Weight did not differ between groups. The decrease in SBP was directly and independently associated with the SBP at diagnosis and the plasma amlodipine concentration. CONCLUSIONS AND CLINICAL IMPORTANCE: Cats with higher blood pressure at diagnosis might require a greater dose of amlodipine to control their blood pressure adequately. Differences in amlodipine pharmacokinetics between cats do not seem to play a role in the antihypertensive response

40Ar/39Ar and U-Pb mineral ages from the Brookville Gneiss: implications for terrane analysis and evolution of Avalonian "basement" in southern New Brunswick

New 40Ar/39Ar hornblende and U-Pb zircon data from units previously thought to represent basement to the Avalon composite terrane in southern New Brunswick yield latest Precambrian or early Cambrian metamorphic cooling ages and a late Precambrian protolith age. Hornblendes from the Brookville Gneiss and from an intrusive amphibolite body within the gneiss yield 40Ar/39Ar isotope correlation ages of 542 ± 4 and 338 ± 2 Ma, respectively. These ages are interpreted to date post-amphibolite facies metamorphic cooling. Euhedral zircons from the Point Pleasant orthogneiss, a quartz dioritic gneiss previously interpreted to be the oldest component of the Brookville Gneiss, show slight inheritance and yield 247Pb/206Pb ages ranging from 603 to 631 Ma. The youngest of these is interpreted to be a maximum age for the orthogneiss protolith. These results, together with other recent U-Pb age data, conflict with previous interpretations of the Brookville Gneiss and the metasedimentary Green Head Group with which it is associated, as a mobilized Proterozoic basement-cover succession upon which an Avalonian ensialic arc developed at c. 600-633 Ma. Instead, the age of the orthogneiss matches that of the arc, and the orthogneiss protolith is likely to have been originally intrusive into the Green Head Group. Although the arc succession is unaffected by high-grade metamorphism, the metamorphic cooling age recorded in the "basement" closely follows evidence of within-arc extension at c. 330 Ma. Hence, the arc/"basement" contrasts in tectonothermal regime could be those of varying structural level within the Avalonian arc rather than requiring the proposed existence of entirely separate terranes. R&#xC9;SUM&#xC9; De nouvelles donn&#xE9;es 40Ar/39Ar sur hornblendes et U-Pb sur zircons, issues d'unit&#xE9;s consid&#xE9;r&#xE9;es jadis comme repr&#xE9;sentant le socle de la Lani&#xE8;re composite d'Avalon au Nouveau-Brunswick meridional, ont livr&#xE9; des &#xE2;ges de refroidissement m&#xE9;tamorphique finipr&#xE9;cambriens ou &#xE9;ocambriens ainsi qu'un &#xE2;ge de protolithe tardipr&#xE9;ambrien. Des hornblendes extraites du Gneiss de Brookville ont livr&#xE9; un &#xE2;ge de corr&#xE9;lation isotopique par 40Ar/39Ar de 542 ± 4 Ma; d'autres, provenant d'un b&#xE2;ti amphibolitique intrusif au sein du gneiss, ont livr&#xE9; un &#xE2;ge de 538 ± 2 Ma. On interpr&#xE8;te ces &#xE2;ges comme datant le refroidissement m&#xE9;tamorphique au-del&#xE2; du faci&#xE8;s &#xE0; amphibolites. Des zircons idiomorphes provenant de l'orthogneiss de Point Pleasant, un gneiss quartzodioritique interpr&#xE8;t auparavant comme le plus ancient constituant du Gneiss de Brookville, montrent un 1&#xE9;ger remaniement et livrent des &#xE2;ges 247Pb/206Pb s'&#xE9;talant de 603 &#xE0; 631 Ma. On interpr&#xE8;t&#xE9; le plus jeune de ces &#xE2;ges comme l'&#xE2;ge maximal du protolithe de l'orthogneiss. Ces r&#xE9;sultats, tout comme d'autres donn&#xE9;es U-Pbrecentes, contredisent les interpr&#xE8;tations ant&#xE9;rieures consid&#xE9;ranl le Gneiss de Brookville et le Groupe m&#xE9;tas&#xE9;dimentaire de Green Head, auquel il s'associe, comme une succession socle-couverture mobilis&#xE9;e prot&#xE9;rozoique sur laquelle un arc sialique avalonien s'est d&#xE9;velopp&#xE9; il y a en v. 600 &#xE0; 635 Ma. L'&#xE2;ge de l'orthogneiss correspond plut&#xF4;t &#xE2; celui de l'arc et il est probable que le protolithe de l'orthogneiss faisait &#xE0; l'origine intrusion au sein du Groupe de Green Head. Bien que la succession d'arc n'ait subi aucun m&#xE9;tamorphisme de degr&#xE9; &#xE9;1ev&#xE9; l'&#xE2;ge de refroidissement m&#xE9;tamorphique enregistr&#xE9; dans le "socle" Concorde &#xE9;troitement avec la manifestation d 'une extension intra-arc vers 550 Ma. Par consequent, les contrastes de r&#xE9;gime tectonothermique arc/"socle" pourraient refl&#xE8;ter les variations du niveau structural au sein de l'arc avalonien plut&#xF4;t que necessiter l'existence propos&#xE9;e de lani&#xE8;res tout a fait distinctes. [Traduit par le journal

Reducing transonic wind tunnel sting interference effects for concealed store release testing

Internal weapons bays are becoming increasingly common on aircraft for reasons of stealth and aerodynamic performance, and will be even more prevalent on coming generations of unmanned combat aerial vehicles (UCAVs). Wind tunnel testing of store releases to assess forces and moments for safety and clearance must be conducted with a store mounted to an angled strut rather than a conventional rear sting, to allow the full range of motion as the store “drops” from inside the aircraft. Interference from this strut can disrupt the flowfields and thus the reliability of moments obtained, and therefore an investigation was conducted to quantify the potential extent of discrepancies; original small-scale transonic wind tunnel testing was undertaken in a limited program which was supported by extensive numerical work. It was concluded that the precise geometry of the strut/store interface was of critical importance, with a typical design producing non-linear interference at high angles of attack. A simple improved design is proposed – making use of a blended interface and a more appropriate supercritical aerofoil strut cross section – yielding marked improvements in force and moment predictions

Interactions of shock tube exhaust flows with laminar and turbulent flames

The interactions of flow features emitting from open-ended shock tubes with free-standing propane flames have been investigated using high-speed schlieren imaging and high-frequency pressure measurements, with additional data from validated numerical modeling. Both compressed air-driven interactions with non-pre-mixed laminar diffusion flames (small-scale) and explosively-driven interactions with turbulent non-pre-mixed turbulent flames (large-scale) were tested for various flame locations and shock tube stagnation pressures (and therefore Mach numbers). In the small-scale tests it was observed that the flames were not significantly influenced by the passage of either the initial shock if placed close to the tube exit, or the weaker pressure waves downstream if the flame was placed further away. Four types of interaction were classified, three of which led to permanent extinguishment of the flames. The most effective mechanism of extinguishment for a flame in-line with the exhaust was the axial exhaust jet of expanding air, which served to push the flame off the fuel source either at close range (Type I) or more slowly at a distance (Type II), after which rapid cessation of combustion occurred. With the flame positioned to one side of the path of the jet, strong loop vortices achieved a similar overall outcome of extinguishment, albeit with very different flame behavior in reaction to the strong turbulence and vorticity induced by the passing flow (Type III). In all cases bar one, the disruption to the fire triangle caused by these flow effects was sufficient to extinguish – rapidly and permanently – the flame. However, at a sufficient lateral offset of the flame from the shock tube exit, the strength of rotating flow being entrained into the diffusing vortex ring was not sufficient to remove and disperse the heat from the extinguished flame (Type IV), such that re-ignition could occur. By contrast, in the large-scale tests with a significantly different shock pressure profile and a flame approximately 1 order of magnitude greater, extinguishment in all cases for all shock strengths and locations was achieved by the shock itself (accelerating combustion) and the following “blast wind” impulsively moving the flame off the fuel source, with the vortices having negligible effect at the given testing locations (Type V)

An evaluation of enteral nutrition practices and nutritional provision in children during the entire length of stay in critical care

&lt;b&gt;Background&lt;/b&gt; Provision of optimal nutrition in children in critical care is often challenging. This study evaluated exclusive enteral nutrition (EN) provision practices and explored predictors of energy intake and delay of EN advancement in critically ill children.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Methods&lt;/b&gt; Data on intake and EN practices were collected on a daily basis and compared against predefined targets and dietary reference values in a paediatric intensive care unit. Factors associated with intake and advancement of EN were explored.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Results&lt;/b&gt; Data were collected from 130 patients and 887 nutritional support days (NSDs). Delay to initiate EN was longer in patients from both the General Surgical and congenital heart defect (CHD) Surgical groups [Median (IQR); CHD Surgical group: 20.3 (16.4) vs General Surgical group: 11.4 (53.5) vs Medical group: 6.5 (10.9) hours; p &lt;= 0.001]. Daily fasting time per patient was significantly longer in patients from the General Surgical and CHD Surgical groups than those from the Medical group [% of 24 h, Median (IQR); CHD Surgical group: 24.0 (29.2) vs General Surgical group: 41.7 (66.7) vs Medical group: 9.4 (21.9); p &lt;= 0.001]. A lower proportion of fluids was delivered as EN per patient (45% vs 73%) or per NSD (56% vs 73%) in those from the CHD Surgical group compared with those with medical conditions. Protein and energy requirements were achieved in 38% and 33% of the NSDs. In a substantial proportion of NSDs, minimum micronutrient recommendations were not met particularly in those patients from the CHD Surgical group. A higher delivery of fluid requirements (p &lt; 0.05) and a greater proportion of these delivered as EN (p &lt; 0.001) were associated with median energy intake during stay and delay of EN advancement. Fasting (31%), fluid restriction (39%) for clinical reasons, procedures requiring feed cessation and establishing EN (22%) were the most common reasons why target energy requirements were not met.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Conclusions&lt;/b&gt; Provision of optimal EN support remains challenging and varies during hospitalisation and among patients. Delivery of EN should be prioritized over other "non-nutritional" fluids whenever this is possible.&lt;p&gt;&lt;/p&gt

Investigation of new concepts of adaptive devices Quarterly technical report, 15 Dec. 1967 - 14 Mar. 1968

Fabrication, properties, and application of metal nitride semiconductor/variable threshold transistor memory devic

Prolonged refractory status epilepticus following acute traumatic brain injury: a case report of excellent neurological recovery

INTRODUCTION: Refractory status epilepticus (RSE) secondary to traumatic brain injury (TBI) may be under-recognized and is associated with significant morbidity and mortality. METHODS: This case report describes a 20 year old previously healthy woman who suffered a severe TBI as a result of a motor vehicle collision and subsequently developed RSE. Pharmacological coma, physiological support and continuous electroencephalography (cEEG) were undertaken. RESULTS: Following 25 days of pharmacological coma, electrographic and clinical seizures subsided and the patient has made an excellent cognitive recovery. CONCLUSION: With early identification, aggressive physiological support, appropriate monitoring, including cEEG, and an adequate length of treatment, young trauma patients with no previous seizure history and limited structural damage to the brain can have excellent neurological recovery from prolonged RSE