The effects of supraphysiological oestrogen levels on ventricular repolarisation parameters

Background: The frequency of arrhythmic death developing without a structural cardiac disease is higher in women. Also, female sex is an independent risk factor regarding development of torsades de pointes. Several studies have been conducted on the physiological and therapeutic effects of sex hormones on the cardiac conduction system. Aim: In this study we aim to examine the effect of hormonal changes, especially supraphysiological E2 level changes occurring during in vitro fertilisation treatment, on ventricular repolarisation parameters. Methods: The study included female patients aged between 23 and 39 years, who were administered controlled ovarian hyperstimulation treatment. Patients’ electrocardiograms and blood samples were obtained and analysed before and after the ovarian hyperstimulation treatment. Results: Mean QTc intervals before ovarian hyperstimulation were 411.9 ± 23.7 ms. Measurements during oestradiol peak were calculated as 420.7 ± 23.3 ms, and the QTc interval increase was significant (p = 0.007). Corrected QT dispersion averages were not significant before or after hyperstimulation (53 ± 17 ms vs. 54.5 ± 18.2 ms, respectively, p > 0.05). Tp-e, J-T peak, and PR dispersion changes were not significant after the ovarian hyperstimulation therapy. Conclusions: Supraphysiological oestradiol levels that occur during controlled ovarian hyperstimulation cause prolongation of QTc intervals, but not to a pathological level. Although this prolongation is not significant in healthy individuals, it might increase ventricular arrhythmia risk in patients with congenital long QT syndrome and in patients taking medication that prolongs QT

Comparing Dental and Pharmacy Students’ Perceptions on Public Health and Preventive Health Care Course

Objectives : A Public health course has an important role in the undergraduate education of pharmacy and dentistry in terms of emphasizing preventive care. The purpose of this study is to evaluate the views of pharmacy and dentistry students on a public health course and preventive health care. Methods: 173 students enrolled at Ege University, Faculties of Pharmacy and Dentistry completed a SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis and replied to 18 Likert type question to determine their perceptions on a public health course and preventive health care. The comments of the students were reviewed and categorized into key themes. Results: SWOT analysis and the results of quantitative Likert type questions supported each other. According to the quantitative results, there was no significant difference between the scores of students from both schools in terms of their statements about the public health course and preventive care. Both groups of students mentioned the contribution of the public health course to their professions in the future. They also appreciated the importance of preventive care in the health services

Clinical Evaluation of the Joints of Patients with Hemophilia

Objective: Hemophilia is the most common and serious disease of congenital coagulation factor deficiency and causes arthropathy by hemarthrosis. A proper and timely treatment can decrease morbidity in patients. The objective of this study to evaluate the joints of patients with hemophilia in the Van region. Method: 30 patients of hemophilia who applied to our clinic between March 2009 and October 2010 were included to study. The patients were between 18 and ndash;60 years old (the mean age is 29,9) and, based on clinical and radiological criteria, were diagnosed with hemophilic arthropathy. The clinical examination of the patients' joints, frequency of intra-articular bleeding, age of diagnosis and factor levels were evaluated, and whether patients were given prophylaxis or not was taken in consideration. Results:. 25 of the patients (83,3%) had severe hemophilia and their factor level was below 1%. The mean diagnosis age of our patients was 11,1. 7 of the patients (23,3%) were not given prophylaxis treatment. Limited range of motion of the joints, except shoulders, was statistically meaningful when compared to the control group (p<0.001). Knee was the most commonly affected joint (48,2%). In order of decreasing frequency, the elbow, hip, ankle and shoulder were the other affected joints. Surgical procedures were applied on 9 patients (30%). Conclusion: Treatment and monitoring of patients with hemophilia requires a multidisciplinary approach. Early diagnosis, treatment, rehabilitation and a constant monitoring will be effective in preventing arthropaty. [Arch Clin Exp Surg 2014; 3(4.000): 233-239

Comparison of Clinical Outcomes of Single-Incision Versus Conventional Multiport Laparoscopic Distal Pancreatectomy: A Single Institution Experience

Objectives: Single-incision laparoscopic procedures have been gaining popularity in recent years due to their minimal incisional morbidity and improved cosmetic outcomes. Herein, we will compare the feasibility and outcomes of single-incision and conventional multiport laparoscopic distal pancreatectomy

Foreign body penetrations of hand and wrist: a retrospective study

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