Impacts of environmental factors and human disturbance on composition of roadside vegetation in Xishuangbanna National Nature Reserve of Southwest China

AbstractVegetation-disturbance-environment relationships in Xishuangbanna Nature Reserve (XNR) was examined using multivariate analysis to understand the impacts of environmental factors and human disturbance on vegetation along the highway corridor. The results show that native forests were the best habitat for protected/endangered species and native species. The exotic plants Eupatorium odoratum and Eupatorium adenophora were found primarily in secondary forests and their presence was positively associated with altitude and soil potassium concentrations. The distribution of two protected plants, Phoebe nanmu and Pometia tomentosa, was negatively associated with road disturbance. Understanding the complex effects of environmental factors and human disturbance is key for developing conservation and restoration strategies for roadside plant ecosystems

Horava-Lifshitz Dark Energy

We formulate Horava-Lifshitz cosmology with an additional scalar field that leads to an effective dark energy sector. We find that, due to the inherited features from the gravitational background, Horava-Lifshitz dark energy naturally presents very interesting behaviors, possessing a varying equation-of-state parameter, exhibiting phantom behavior and allowing for a realization of the phantom divide crossing. In addition, Horava-Lifshitz dark energy guarantees for a bounce at small scale factors and it may trigger the turnaround at large scale factors, leading naturally to cyclic cosmology.Comment: 17 pages, no figures, version published at EJP

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

Cancer Signaling networks and Molecular Therapeutic

Discovery of a highly active anticancer analogue of cardamonin that acts as an inducer of caspase-dependent apoptosis and modulator of the mTOR pathway

Nineteen analogues of cardamonin were semi-synthesized and tested against A549 and HK1 cell lines. The analogues were fully characterized via IR and NMR analyses, while compound 19 (a Cu (II) complex of cardamonin) was further characterized via HRMS, ELEMENTAL ANALYSIS, TGA and UV-VIS spectroscopy. Results of the MTS cell viability assay showed that several derivatives possessed cytotoxic activities that were several-fold more potent than cardamonin. Compound 19 was the most potent analogue possessing IC50 values of 13.2 µM and 0.7 µM against A549 and HK1 cells, corresponding to a 5- and 32-fold increase in activity, respectively. Furthermore, the active analogues, especially 19, have generally demonstrated lower toxicity towards normal MRC5 cells. SAR analysis showed the importance of the ketone and alkene groups for bioactivity, while substituting cardamonin’s phenolic groups with more polar moieties resulted in activity enhancement. As part of the SAR study and further exploration of chemical space, the effect of metal coordination on cytotoxicity was also investigated, but it was only possible to successfully obtain the Cu (II) complex of cardamonin (19), and results showed that the metal ion enhanced activity. 19 was also able to significantly inhibit the migration of A549 and HK1 cells. Further studies have shown that the most active analogue, 19, induced DNA damage resulting in G2/M-phase cell-cycle arrest in both cell lines. These events further led to the induction of apoptosis by 19 via caspase-3/7 and caspase-9 activation, PARP cleavage and downregulation of Mcl-1 expression. Finally, 19 inhibited the expression levels of p-mTOR and p-4EBP1. These data indicated that 19 exerted its anticancer activity, at least in part, via inhibition of the mTOR signalling pathway

OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ

Cancer Signaling networks and Molecular Therapeutic