A novel reaction of vicinal tricarbonyl compounds with the isocyanide-DMAD zwitterion: formation of highly substituted furan derivatives

The vicinal tricarbonyl system participates in a novel reaction with the zwitterion derived from isocyanide and dimethyl acetylenedicarboxylate to form fully substituted furan derivatives

Air Wear—Portable Oxygen Aid Device

Since the outbreak of COVID-19 pandemic, hospitals have experienced an overwhelming increase in patients needing respiratory assistance. Our client identified the need for a sustainable, affordable, and portable outpatient device that will provide supplemental oxygen and assisted breathing to speed up the patient recovery process. Our team accomplished to design a device that contains a more sustainable oxygen supply method, has a longer functional duration, is safer and ergonomic, as well as compact

Air Wear

Since the outbreak of COVID-19 pandemic, hospitals have experienced an overwhelming increase in patients needing respiratory assistance. Our client identified the need for a sustainable, affordable, and portable outpatient device that will provide supplemental oxygen and assisted breathing to speed up the patient recovery process. Our team accomplished to design a device that contains a more sustainable oxygen supply method, has a longer functional duration, is safer and ergonomic, as well as compact

A comparative study on the isolation and cerium (IV) ammonium nitrate mediated oxidative transformation of oleanolic acid and ursolic acid

598-603<span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-bidi-font-family:"times="" roman";letter-spacing:-.1pt;mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">Oleanolic acid and Ursolic acid, two important pentacyclic triterpenes have been extracted from two different sources and have been subjected to oxidation using cerium (IV) ammonium nitrate in methanol. Two new oxidation products, namely a lactone and an ester have been obtained which however show decreased antibacterial activity in comparison to the parent compounds.</span

A novel three-component reaction of triphenylphosphine, DMAD, and electron-deficient styrenes: facile synthesis of cyclopentenyl phosphoranes

The zwitterion formed from triphenylphosphine and DMAD adds to electron-deficient styrenes to form stable cyclopentenyl phosphoranes. This is the first example of such a zwitterion in which the phosphine is incorporated into the product

Loeffler\u27s Endocarditis and Hypereosinophilic Syndrome

Loeffler\u27s endocarditis and hypereosinophilic syndromes are a unique group of infiltrative disorders characterized by hypereosinophilia and inflammatory thrombotic and ultimately fibrotic involvement of the heart, leading to multiple complications including valve involvement, thromboembolic phenomena and heart failure. Clinical recognition, comprehensive laboratory and multimodality imaging diagnostic workup, and early initiation of treatment have been shown to slow down the progression and promote remission. This review addresses a detailed analysis of Loeffler\u27s endocarditis and hypereosinophilic syndromes

An expedient synthesis of spirooxindoles incorporating 2-amino pyran-3-carbonitrile unit employing dialkyl acetone-1,3-dicarboxylates

<p>Spirooxindoles are a class of molecules possessing significant biological effects such as antiviral, antifungal, antibacterial and anticancer properties. Herein we report a series of spirooxindole molecules having 2-amino pyran-3-carbonitrile and with two ester groups. These molecules were prepared by the reaction of dialkyl acetone-1,3-dicarboxylate and isatilidenes in the presence of triethyl amine.</p

One-pot, four-component reaction of isocyanides, dimethyl acetylenedicarboxylate, and cyclobutene-1,2-diones: a synthesis of novel spiroheterocycles

Isocyanides, dimethyl acetylenedicarboxylate, and cyclobutene-1,2-diones react in one-pot to afford novel spirocyclic compounds with double insertion of the isocyanide

Doxorubicin-Polysorbate 80 Conjugates: Targeting Effective and Sustained Delivery to the Brain

Targeting therapeutic agents to the brain to treat the central nervous system (CNS) diseases is a major challenge due to the blood-brain-barrier (BBB). In this study, an attempt was made to deliver a model drug such as doxorubicin (DOX) to the brain in a mice model through DOX-Polysorbate 80 (DOX-PS80) conjugates. DOX was successfully conjugated with the non-ionic surfactant Polysorbate 80 (PS80) by carbamate linkage and the conjugate was characterized by different spectroscopic techniques such as FTIR, UV-Visible and NMR. The DOX conjugation efficacy was found to be 43.69 ± 4.72 %. The in vitro cumulative release of DOX from the conjugates was found to be 4.9 ± 0.8 % in PBS of pH 7.3 and 3.9 ± 0.6 % in simulated cerebrospinal fluid (CSF) of pH 7.3 at the end of 10 days. In vitro BBB permeability assay was carried out using bEnd.3 cells and DOX-PS80 conjugate showed a 3-fold increase in BBB permeability compared to controls. In vitro cytotoxicity assay using U251 human glioblastoma cells showed an IC50 value of 38.10 µg/mL for DOX-PS80. Cell uptake studies revealed that DOX-PS80 was effectively taken up (90%) by the bEnd.3 and U251 cells and localized in cytoplasm at the end of 24 h. Tumor spheroid assay and in vivo experiments in Swiss albino mice demonstrated the possibility of DOX-PS80 conjugate crossing the BBB and delivering the drug molecules to the target site for treating CNS disorders