Chiral Vortons and Cosmological Constraints on Particle Physics

We investigate the cosmological consequences of particle physics theories that admit stable loops of current-carrying string - vortons. In particular, we consider chiral theories where a single fermion zero mode is excited in the string core, such as those arising in supersymmetric theories with a D-term. The resulting vortons formed in such theories are expected to be more stable than their non-chiral cousins. General symmetry breaking schemes are considered in which strings formed at one symmetry breaking scale become current-carrying at a subsequent phase transition. The vorton abundance is estimated and constraints placed on the underlying particle physics theories from cosmological observations. Our constraints on the chiral theory are considerably more stringent than the previous estimates for more general theories.Comment: minor corrections made. This version will appear in PR

Recent developments in Vorton Theory

This article provides a concise overview of recent theoretical results concerning the theory of vortons, which are defined to be (centrifugally supported) equilibrium configurations of (current carrying) cosmic string loops. Following a presentation of the results of work on the dynamical evolution of small circular string loops, whose minimum energy states are the simplest examples of vortons, recent order of magnitude estimates of the cosmological density of vortons produced in various kinds of theoretical scenario are briefly summarised.Comment: 6 pages Latex. Contribution to 1996 Cosmology Meeting, Peyresq, Franc

Cosmic Vortons and Particle Physics Constraints

We investigate the cosmological consequences of particle physics theories that admit stable loops of superconducting cosmic string - {\it vortons}. General symmetry breaking schemes are considered, in which strings are formed at one energy scale and subsequently become superconducting in a secondary phase transition at what may be a considerably lower energy scale. We estimate the abundances of the ensuing vortons, and thereby derive constraints on the relevant particle physics models from cosmological observations. These constraints significantly restrict the category of admissible Grand Unified theories, but are quite compatible with recently proposed effects whereby superconducting strings may have been formed close to the electroweak phase transition.Comment: 33 pages, 2 figures, RevTe

Renormalisation of gravitational self interaction for wiggly strings

It is shown that for any elastic string model with energy density $U$ and tension $T$, the divergent contribution from gravitational self interaction can be allowed for by an action renormalisation proportional to $(U-T)^2$. This formula is applied to the important special case of a bare model of the transonic type (characterised by a constant value of the product $UT$) that represents the macroscopically averaged effect of shortwavelength wiggles on an underlying microscopic model of the Nambu-Goto type (characterised by $U=T$).Comment: 11 pages, Latex; original 8 page version extended to include estimates of relevant orders of magnitude. To be published in Physical Review,

Semantic catalogs for life cycle assessment data

AbstractLife cycle assessment (LCA) is a highly interdisciplinary field that requires knowledge from different domains to be gathered and interpreted together. Although there are relatively few major data sources for LCA, the data themselves are presented with highly heterogeneous formats, interfaces, and distribution mechanisms. The lack of agreement among data providers for descriptions of processes and flows creates substantial barriers for information sharing and reuse of practitioners’ models.Nevertheless, the many data resources share a common logic. The use of Semantic Web technologies and text mining techniques can facilitate the interpretation of data from diverse sources. Numerous existing efforts have been made to articulate a knowledge model for LCA. In March of 2015 a joint workshop was held that brought together leading international domain experts with ontology engineers to develop a set of simple models called ontology design patterns (ODPs) for LCA information. In this paper we build on the outcomes of the workshop, as well as prior published works, to derive a minimal “consensus model” for LCA. We use the consensus model to derive a description of an LCA “catalog” that can be used to express the semantic content of a data resource. We generate catalogs of several prominent databases, and make those catalogs available to the public for independent use. Finally, we “link” those catalogs to existing knowledge models using JSON-LD, a linked data format that can expose the catalog contents to Semantic Web tools.We then show by example how the catalogs may be used to answer questions about the scope, coverage, and comparability of data, both within and across data sources, that are difficult to answer when the contents of the catalogs are provided independently and inconsistently. We discuss how the use of semantic catalogs can help address challenges that initiatives such as the “Global Network of Interoperable LCA Databases – Global LCA Data Access” are facing today

Kane County water resources investigations : final report on geologic investigations

Kane County Water Resources Department, Contract No. 02-279Ope

Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I

Control of calcium binding to and dissociation from cardiac troponin C (TnC) is essential to healthy cardiac muscle contraction/relaxation. There are numerous aberrant post-translational modifications and mutations within a plethora of contractile, and even non-contractile, proteins that appear to imbalance this delicate relationship. The direction and extent of the resulting change in calcium sensitivity is thought to drive the heart toward one type of disease or another. There are a number of molecular mechanisms that may be responsible for the altered calcium binding properties of TnC, potentially the most significant being the ability of the regulatory domain of TnC to bind the switch peptide region of TnI. Considering TnI is essentially tethered to TnC and cannot diffuse away in the absence of calcium, we suggest that the apparent calcium binding properties of TnC are highly dependent upon an “effective concentration” of TnI available to bind TnC. Based on our previous work, TnI peptide binding studies and the calcium binding properties of chimeric TnC-TnI fusion constructs, and building upon the concept of effective concentration, we have developed a mathematical model that can simulate the steady-state and kinetic calcium binding properties of a wide assortment of disease-related and post-translational protein modifications in the isolated troponin complex and reconstituted thin filament. We predict that several TnI and TnT modifications do not alter any of the intrinsic calcium or TnI binding constants of TnC, but rather alter the ability of TnC to “find” TnI in the presence of calcium. These studies demonstrate the apparent consequences of the effective TnI concentration in modulating the calcium binding properties of TnC

Forgiveness-Reconciliation and Communication-Conflict-Resolution Interventions Versus Retested Controls in Early Married Couples

The first 6 months of marriage are optimal for marriage enrichment interventions. The Hope-Focused Approach to couple enrichment was presented as two 9-hr interventions--(a) Handling Our Problems Effectively (HOPE), which emphasized communication and conflict resolution, and (b) Forgiveness and Reconciliation through Experiencing Empathy (FREE). HOPE and FREE were compared with repeated assessment controls. Couples were randomly assigned and were assessed at pretreatment (t1); 1 month posttreatment (t2) and at 3- (t3), 6- (t4), and 12-month (t5) follow-ups using self-reports. In addition to self-report measures, couples were assessed at t1, t2, and t5 using salivary cortisol, and behavioral coding of decision making. Of 179 couples who began the study, 145 cases were analyzed. Both FREE and HOPE produced lasting positive changes on self-reports. For cortisol reactivity, HOPE and FREE reduced reactivity at t2, but only HOPE at t5. For coded behaviors, control couples deteriorated; FREE and HOPE did not change. Enrichment training was effective regardless of the focus of the training

Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development.

BACKGROUND: We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be sequenced. The tammar has many unusual biological characteristics, including the longest period of embryonic diapause of any mammal, extremely synchronized seasonal breeding and prolonged and sophisticated lactation within a well-defined pouch. Like other marsupials, it gives birth to highly altricial young, and has a small number of very large chromosomes, making it a valuable model for genomics, reproduction and development. RESULTS: The genome has been sequenced to 2 × coverage using Sanger sequencing, enhanced with additional next generation sequencing and the integration of extensive physical and linkage maps to build the genome assembly. We also sequenced the tammar transcriptome across many tissues and developmental time points. Our analyses of these data shed light on mammalian reproduction, development and genome evolution: there is innovation in reproductive and lactational genes, rapid evolution of germ cell genes, and incomplete, locus-specific X inactivation. We also observe novel retrotransposons and a highly rearranged major histocompatibility complex, with many class I genes located outside the complex. Novel microRNAs in the tammar HOX clusters uncover new potential mammalian HOX regulatory elements. CONCLUSIONS: Analyses of these resources enhance our understanding of marsupial gene evolution, identify marsupial-specific conserved non-coding elements and critical genes across a range of biological systems, including reproduction, development and immunity, and provide new insight into marsupial and mammalian biology and genome evolution