35 research outputs found
Psychological Science in the Wake of COVID-19: Social, Methodological, and Metascientific Considerations
The COVID-19 pandemic has extensively changed the state of psychological science, from what research questions psychologists can ask to which methodologies psychologists can employ to investigate them. In this article, we offer a perspective on how to optimize new research in the pandemicâs wake. As this pandemic is inherently a social phenomenonâan event that hinges upon human-to-human contactâwe focus on socially relevant subfields of psychology. We highlight specific psychological phenomena that have likely shifted due to the pandemic and discuss theoretical, methodological, and practical considerations of conducting research on these phenomena. Following this discussion, we evaluate meta-scientific issues that have been amplified by the pandemic. We aim to demonstrate how theoretically grounded views on the COVID-19 pandemic can help make psychological science strongerânot weakerâin its wake
Socioeconomic mobility and talent utilization of workers from poorer backgrounds: The overlooked importance of within-organization dynamics
Socioeconomic mobility, or the ability of individuals to improve their socioeconomic standing through merit-based contributions, is a fundamental ideal of modern societies. The key focus of societal efforts to ensure socioeconomic mobility has been on the provision of educational opportunities. We review evidence that even with the same education and job opportunities, being born into a poorer family undermines socioeconomic mobility due to processes occurring within organizations. The burden of poorer background might, ceteris paribus, be economically comparable to the gender gap. We argue that in the societal and scientific effort to promote socioeconomic mobility, the key context in which mobility is supposed to happenâorganizationsâas well as the key part of the life of people striving toward socioeconomic advancementâthat as working adultsâhave been overlooked. We integrate the organizational literature pointing to key within-organizational processes impacting objective (socioeconomic) success with research, some emergent in organizational sciences and some disciplinary, on when, why, and how people from poorer backgrounds behave or are treated by others in the relevant situations. Integrating these literatures generates a novel and useful framework for identifying issues people born into poorer families face as employees, systematizes extant evidence and makes it more accessible to organizational scientists, and allows us to lay the agenda for future organizational scholarshi
Normal regulation of calcitriol production in Gy mice. Evidence for biochemical heterogeneity in the X-linked hypophosphatemic diseases.
PDGF induces tyrosine phosphorylation in osteoblast-like cells: relevance to mitogenesis
Platelet-Rich Plasma: Quantification of Growth Factor Levels and the Effect on Growth and Differentiation of Rat Bone Marrow Cells
Sustained antihypertensive activity of telmisartan vs valsartan
DBP reduction in the last 6 h of the once-daily dosing interval and 24-h mean DBP control when a dose is missed are significantly superior with telmisartan than with valsartan. Thus, telmisartan due to its longer half-life offers more sustained BP control, especially at the end of the dosing period and provides sustained efficacy in poorly compliant patients
Dipyridamoleâinduced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc
Background and purpose
Our objective was to investigate the association between recurrent stroke risk and headache induced by extendedârelease dipyridamole (ERâDP) when administered alone or with lowâdose aspirin (ASA+ERâDP).
Methods
This was a post hoc analysis of prospectively collected data on recurrent stroke risk and headache as an adverse event or reason for treatment discontinuation from the PRoFESS (NÂ =Â 20Â 332) and ESPS2 (NÂ =Â 6602) trials. Hazard ratios (HRs) for recurrent stroke were calculated using the Cox model.
Results
In PRoFESS, the 2.5âyear recurrent stroke risk in patients receiving ASA+ERâDP was 8.2% in those with headache within 7Â days of starting treatment and 9.4% in those without [HR 0.85, 95% confidence interval (CI) 0.73â0.98; PÂ =Â 0.03]. Recurrent stroke risk was 5.0% in patients who discontinued ASA+ERâDP due to headache by day 90 versus 9.2% in those who did not (HR 0.52, 95% CI 0.35â0.77; PÂ =Â 0.001). No such difference was observed in clopidogrelâtreated patients. In ESPS2, risk of recurrent stroke was 6.2% in patients who discontinued ASA+ERâDP due to headache by day 90 versus 9.8% in patients who did not (HR 0.62, 95% CI 0.31â1.27; PÂ =Â 0.19) and 7.3% in patients who discontinued ERâDP due to headache by day 90 versus 13.2% in those who did not (HR 0.53, 95% CI 0.27â1.04; PÂ =Â 0.06).
Conclusions
Patients taking ASA+ERâDP in PRoFESS who developed headache had significantly reduced stroke recurrence risk versus those without headache. Similar (nonâsignificant) findings for ASA+ERâDP and ERâDP in ESPS2 suggest that dipyridamoleâinduced headache may reflect better cerebrovascular function