Fast Multi-user Detector for a Time-varying CDMA System

This paper investigates methods to reduce the amount of computation needed to detect information bits using a linear detector for a CDMA system. We show windowing technique coupled with pipelining can reduce the amount of computation without significantly sacrificing the performance of linear feedback detector. We also describe efficient techniques to adapt to a dynamic system where the system parameters vary due to the change in delays associated with individual users.Nokia CorporationNational Science FoundationTexas Advanced Technology Progra

Low Complexity Iterative Multiuser Detection and Decoding for Real-Time Applications

This paper presents a low-complexity multiuser decoding technique that can be implemented in real time for a convolutionally coded direct sequence code division multiple access (DS-CDMA) system. The main contribution, denoted here as the iterative prior update (IPU), consists of iterative interference cancellation and prior updates on sequences of coded bits combined with M-algorithm and list decoding. We illustrate performance gains over other low-complexity sequence detection and decoding strategies and argue that the algorithm converges within a few iterations and requires only a small size buffer for keeping track of the priors along iterations. The fact that the we can use existing available architectures for Viterbi decoding with slight modifications and can meet the real-time processing constraints makes the IPU algorithm an attractive alternative for cellular systems

Oligomerization of the human immunodeficiency virus type 1 (HIV-1) Vpu protein – a genetic, biochemical and biophysical analysis

<p>Abstract</p> <p>Background</p> <p>The human immunodeficiency virus type 1(HIV-1) is a complex retrovirus and the causative agent of acquired immunodeficiency syndrome (AIDS). The HIV-1 Vpu protein is an oligomeric integral membrane protein essential for particle release, viral load and CD4 degradation. <it>In silico </it>models show Vpu to form pentamers with an ion channel activity.</p> <p>Results</p> <p>Using Vpu proteins from a primary subtype C and the pNL4-3 subtype B isolates of HIV-1, we show oligomerization of the full-length protein as well as its transmembrane (TM) domain by genetic, biochemical and biophysical methods. We also provide direct evidence of the presence of Vpu pentamers in a stable equilibrium with its monomers <it>in vitro</it>. This was also true for the TM domain of Vpu. Confocal microscopy localized Vpu to the endoplasmic reticulum and Golgi regions of the cell, as well as to post-Golgi vesicles. In fluorescence resonance energy transfer (FRET) experiments in live cells we show that Vpu oligomerizes in what appears to be either the Golgi region or intracellular vesicles, but not in the ER.</p> <p>Conclusion</p> <p>We provide here direct evidence that the TM domain, is critical for Vpu oligomerization and the most favourable channel assembly is a pentamer. The Vpu oligomerization appears to be either the Golgi region or intracellular vesicles, but not in the ER.</p

Universality in Fluid Domain Coarsening: The case of vapor-liquid transition

Domain growth during the kinetics of phase separation is studied following vapor-liquid transition in a single component Lennard-Jones fluid. Results are analyzed after appropriately mapping the continuum snapshots obtained from extensive molecular dynamics simulations to a simple cubic lattice. For near critical quench interconnected domain morphology is observed. A brief period of slow diffusive growth is followed by a linear viscous hydrodynamic growth that lasts for an extended period of time. This result is in contradiction with earlier inclusive reports of late time growth exponent 1/2 that questions the uniqueness of the non-equilibrium universality for liquid-liquid and vapor-liquid transitions.Comment: 6 pages, 5 figure

β-Adrenergic Receptor Stimulation Induces Endoplasmic Reticulum Stress in Adult Cardiac Myocytes: Role in Apoptosis

Accumulation of misfolded proteins and alterations in calcium homeostasis induces endoplasmic reticulum (ER) stress, leading to apoptosis. In this study, we tested the hypothesis that β-AR stimulation induces ER stress, and induction of ER stress plays a pro-apoptotic role in cardiac myocytes. Using thapsigargin and brefeldin A, we demonstrate that ER stress induces apoptosis in adult rat ventricular myocytes (ARVMs). β-AR-stimulation (isoproterenol; 3h) significantly increased expression of ER stress proteins, such as GRP-78, Gadd-153, and Gadd-34, while activating caspase-12 in ARVMs. In most parts, these effects were mimicked by thapsigargin. β-AR stimulation for 15 min increased PERK and eIF-2α phosphorylation. PERK phosphorylation remained higher, while eIF-2α phosphorylation declined thereafter, reaching to ∼50% below basal levels at 3 h after β-AR stimulation. This decline in eIF-2a phosphorylation was prevented by β1-AR, not by β2-AR antagonist. Forskolin, adenylyl cyclase activator, simulated the effects of ISO on eIF-2α phosphorylation. Salubrinal (SAL), an ER stress inhibitor, maintained eIF-2α phosphorylation and inhibited β-ARstimulated apoptosis. Furthermore, inhibition of caspase-12 using z-ATAD inhibited β-AR-stimulated and thapsigargininduced apoptosis. In vivo, β-AR stimulation induced ER stress in the mouse heart as evidenced by increased expression of GRP-78 and Gadd-153, activation of caspase-12, and dephosphorylation of eIF-2α. SAL maintained phosphorylation of eIF-2α, inhibited activation of caspase-12, and decreased β-AR-stimulated apoptosis in the heart. Thus, β-AR stimulation induces ER stress in cardiac myocytes and in the heart, and induction of ER stress plays a pro-apoptotic role

Design of a Fractional Order Phase Shaper for Iso-damped Control of a PHWR under Step-back Condition

Phase shaping using fractional order (FO) phase shapers has been proposed by many contemporary researchers as a means of producing systems with iso-damped closed loop response due to a stepped variation in input. Such systems, with the closed loop damping remaining invariant to gain changes can be used to produce dead-beat step response with only rise time varying with gain. This technique is used to achieve an active step-back in a Pressurized Heavy Water Reactor (PHWR) where it is desired to change the reactor power to a pre-determined value within a short interval keeping the power undershoot as low as possible. This paper puts forward an approach as an alternative for the present day practice of a passive step-back mechanism where the control rods are allowed to drop during a step-back action by gravity, with release of electromagnetic clutches. The reactor under a step-back condition is identified as a system using practical test data and a suitable Proportional plus Integral plus Derivative (PID) controller is designed for it. Then the combined plant is augmented with a phase shaper to achieve a dead-beat response in terms of power drop. The fact that the identified static gain of the system depends on the initial power level at which a step-back is initiated, makes this application particularly suited for using a FO phase shaper. In this paper, a model of a nuclear reactor is developed for a control rod drop scenario involving rapid power reduction in a 500MWe Canadian Deuterium Uranium (CANDU) reactor using AutoRegressive Exogenous (ARX) algorithm. The system identification and reduced order modeling are developed from practical test data. For closed loop active control of the identified reactor model, the fractional order phase shaper along with a PID controller is shown to perform better than the present Reactor Regulating System (RRS) due to its iso-damped nature.Comment: 11 pages, 10figure

Australasian Pigeon Circoviruses Demonstrate Natural Spillover Infection

Pigeon circovirus (PiCV) is considered to be genetically diverse, with a relatively small circular single-stranded DNA genome of 2 kb that encodes for a capsid protein (Cap) and a replication initiator protein (Rep). Australasia is known to be the origin of diverse species of the Order Columbiformes, but limited data on the PiCV genome sequence has hindered phylogeographic studies in this species. To fill this gap, this study was conducted to investigate PiCV in 118 characteristic samples from different birds across Australia using PCR and sequencing. Eighteen partial PiCV Rep sequences and one complete PiCV genome sequence were recovered from reservoir and aberrant hosts. Phylogenetic analyses revealed that PiCV circulating in Australia was scattered across three different subclades. Importantly, one subclade dominated within the PiCV sequenced from Australia and Poland, whereas other PiCV sequenced in this study were more closely related to the PiCV sequenced from China, USA and Japan. In addition, PiCV Rep sequences obtained from clinically affected plumed whistling duck, blue billed duck and Australian magpie demonstrated natural spillover of PiCV unveiled host generalist characteristics of the pigeon circovirus. These findings indicate that PiCV genomes circulating in Australia lack host adapted population structure but demonstrate natural spillover infection

Fractional Order Phase Shaper Design with Routh's Criterion for Iso-damped Control System

Phase curve of an open loop system is flat in nature if the derivative of phase with respect to frequency is zero. With a flat phase curve, the corresponding closed-loop system exhibits an iso-damped property i.e. maintains constant overshoot with the change of gain and with other parametric variations. In recent past application, fractional order (FO) phase shapers have been proposed by contemporary researchers to achieve enhanced parametric robustness. In this paper, a simple Routh tabulation based methodology is proposed to design an appropriate FO phase shaper to achieve phase flattening in a control loop, comprising a system, controlled by a classical PID controller. The method is demonstrated using MATLAB simulation of a second order DC motor plant and also a first order with time delay system.Comment: 4 pages, 4 figures; Proceedings of INDICON 2009 - An IEEE India Council Conference, art. no. 5409434, Dec. 2009, Gujara

Feasibility of a combined camp approach for vector control together with active case detection of visceral leishmaniasis, post kala-azar dermal leishmaniasis, tuberculosis, leprosy and malaria in Bangladesh, India and Nepal: an exploratory study

Background We assessed the feasibility and results of active case detection (ACD) of visceral leishmaniasis (VL), post kala-azar dermal leishmaniasis (PKDL) and other febrile diseases as well as of bednet impregnation for vector control. Methods Fever camps were organized and analyzed in twelve VL endemic villages in Bangladesh, India, and Nepal. VL, PKDL, tuberculosis, malaria and leprosy were screened among the febrile patients attending the camps, and existing bednets were impregnated with a slow release insecticide. Results Among the camp attendees one new VL case and two PKDL cases were detected in Bangladesh and one VL case in Nepal. Among suspected tuberculosis cases two were positive in India but none in the other countries. In India, two leprosy cases were found. No malaria cases were detected. Bednet impregnation coverage during fever camps was more than 80% in the three countries. Bednet impregnation led to a reduction of sandfly densities after 2 weeks by 86% and 32%, and after 4 weeks by 95% and 12% in India and Nepal respectively. The additional costs for the control programmes seem to be reasonable. Conclusion It is feasible to combine ACD camps for VL and PKDL along with other febrile diseases, and vector control with bednet impregnatio