The mediating influence of organizational trust on the relationship between transformational leadership and job satisfaction in the virtual workplace

Research has shown how leadership influences job satisfaction and organizational trust in the virtual workplace. With an increasing number of organizations shifting to these work environments, it is essential to study the effect of leadership on virtual workers. Prior studies suggest that leadership behaviors significantly impact job satisfaction (Hacker et al., 2019), and leadership plays a crucial role in inspiring employees to achieve the goals and objectives of the organization in a virtual workplace (Miller, 2020). Specifically, transformational leadership behaviors that shape the mindset and actions of employees are significant (Abelha et al., 2018). This study proposed a mediation model in which organizational trust influenced the relationship between transformational leadership and job satisfaction. Using a quantitative cross-sectional research design, the researcher addressed the research questions and objectives. This study collected data via an online survey from 415 virtual U.S. workers recruited through Amazon Mechanical Turk (MTurk). Findings from this research study support the relationship between transformational leadership and job satisfaction in the virtual workplace. The study also provides statistical evidence that organizational trust indirectly affects the relationship between transformational leadership and job satisfaction in the virtual workplace. The findings from this study could contribute to training and leadership development initiatives within organizations by recognizing the circumstances that heighten the demand for human capital investments and identifying factors that enable transformational leadership to benefit job satisfaction in the virtual workplace

A PLATFORM FOR IDENTITY: USING LARGE-SCALE EXHIBITION TO POSITION BAHIA, BRAZIL’S CONTEMPORARY CONDITION

Large-scale, perennial exhibitions, or biennials, have become the venue par excellence for the display of contemporary art in the twenty-first century. The majority of scholars interpreting biennials in this relatively new field of study cite the Venice Biennial as the historical origin of the biennial concept, and therefore point of comparison, for each subsequent adaptation of the biennial model to the present. Originally, host cities implemented these events for the purpose of showcasing their industrial, technological, and generally modernizing tendencies, including the sophisticated grasp and execution of Western art trends by their citizens. The combination of experiencing cutting-edge artistic production in the rarified space constructed specifically for its display, set apart from the everyday built environment, imbued the biennial exhibition model with legitimating powers to recognize art trends and elevate the reputation of the cities that hosted them. Dissatisfied and excluded from these Eurocentric events that privileged and exhibited art authored by and about Western subjects, a pioneering curatorial group in the 1980s appropriated and adapted the biennial model to meet the specific needs and realities of the spaces and citizens operating outside these hegemonic centers. This group was known as the Third World Biennials in a new global center, Havana, Cuba. With the recent conclusion of Bahia, Brazil’s third biennial, this study seeks to interpret the purpose of the biennial from Bahia’s specific contemporary context, biennial history, and curatorial design. By outlining conclusions drawn from studies of biennials conducted thus far, outlining the biennial literature produced for this event, and by visual analysis of the Public Archives installation, this research will illustrate how the cumulative, constructive efforts and exchange created between the Bahia biennial and visitors proposes multiple identities for today’s Bahia

Surviving Hurricane Michael - Helping Individuals with Serious and Persistent Mental Illness, Foster Families and Child Welfare Involved Families Prepare and Recover

During a natural disaster the preparation and recovery can be challenging, and is further complicated when working with individuals and families with histories of trauma, serious mental illness, and involvement in child welfare. In natural disaster the social service professionals and their families may also be impacted. This requires agencies and service professionals to provide support for those served while dealing with personal loss and helping their families adapt and recover. This is a perspectives from the field article describing the challenges of preparing for and recovering from Hurricane Michael, which struck the Florida panhandle on October 10, 2018. These perspectives are from three social service workers reflecting on their experiences in working with individuals with serious and persistent mental illnesses, foster families and children involved in child welfare

Future of Veterinary Medicine Explored at Student-Planned Conference

The future is about hard work, new leadership, and organizational models that need to change. It\u27s about changing our scope and our influences while concurrently functioning and changing in a world where our future is in a fast-forward mode

“Best of Both Worlds”: Alumni Perspectives on Honors and the Liberal Arts

This study explores the extent to which skills acquired through liberal arts curricula facilitate immediate post-graduate employment of honors college alumni. Using qualitative methods and semi-structured interviews (n = 16), authors examine the honors college experience and the attainment of skills through the lens of graduates (2017–2020) at a large research institution. Results indicate that while honors alumni identify certain skills that helped them realize initial employment, they were often unable to translate and apply these skills in professional workplaces, particularly nonacademic ones. Data further suggest that liberal arts skills (communication, research competence, critical reasoning, intercultural competence, interdisciplinary inquiry, disciplinary methods, and intellectual engagement) can be cultivated within honors colleges at large universities and are not particular to traditional liberal arts colleges. By focusing on earliest career experience rather than cumulative, this study is an essential contribution to outcomes-related discourse in the field of honors education

Grounded in Relationships of Support: Indigenous Teacher Mentorship in the Rural West

This article explores the power of Indigenous teacher mentorship as essential to address “the change in point of view” long called for in Indigenous education. Drawing from a longitudinal, ethnographic study of an Indigenous teacher education program in a predominantly rural, high need region, we examine the basic questions: What do Indigenous master teachers uniquely bring to teacher education? In what ways do Indigenous master teachers support the development of socially, culturally, linguistically, and place-responsive teachers? Using the theoretical frameworks of Tribal Critical Race Theory (TribalCrit) and situated learning, our findings elucidate the importance of Indigenous mentorship for re-membering and re-claiming Indigenous epistemologies, ontologies, and axiologies in relational and intergenerational learning—practices that interrupt coloniality in teacher education and school leadership. Discussion of Indigenous teacher mentorship centers the importance of relationships between people and place in teaching and learning and asks educators and school leaders to conceptualize Indigenous teacher education as a long-term project of tribal nation building and community wellbeing

Patient- and population-level health consequences of discontinuing antiretroviral therapy in settings with inadequate HIV treatment availability

Background In resource-limited settings, HIV budgets are flattening or decreasing. A policy of discontinuing antiretroviral therapy (ART) after HIV treatment failure was modeled to highlight trade-offs among competing policy goals of optimizing individual and population health outcomes. Methods In settings with two available ART regimens, we assessed two strategies: (1) continue ART after second-line failure (Status Quo) and (2) discontinue ART after second-line failure (Alternative). A computer model simulated outcomes for a single cohort of newly detected, HIV-infected individuals. Projections were fed into a population-level model allowing multiple cohorts to compete for ART with constraints on treatment capacity. In the Alternative strategy, discontinuation of second-line ART occurred upon detection of antiretroviral failure, specified by WHO guidelines. Those discontinuing failed ART experienced an increased risk of AIDS-related mortality compared to those continuing ART. Results At the population level, the Alternative strategy increased the mean number initiating ART annually by 1,100 individuals (+18.7%) to 6,980 compared to the Status Quo. More individuals initiating ART under the Alternative strategy increased total life-years by 15,000 (+2.8%) to 555,000, compared to the Status Quo. Although more individuals received treatment under the Alternative strategy, life expectancy for those treated decreased by 0.7 years (−8.0%) to 8.1 years compared to the Status Quo. In a cohort of treated patients only, 600 more individuals (+27.1%) died by 5 years under the Alternative strategy compared to the Status Quo. Results were sensitive to the timing of detection of ART failure, number of ART regimens, and treatment capacity. Although we believe the results robust in the short-term, this analysis reflects settings where HIV case detection occurs late in the disease course and treatment capacity and the incidence of newly detected patients are stable. Conclusions In settings with inadequate HIV treatment availability, trade-offs emerge between maximizing outcomes for individual patients already on treatment and ensuring access to treatment for all people who may benefit. While individuals may derive some benefit from ART even after virologic failure, the aggregate public health benefit is maximized by providing effective therapy to the greatest number of people. These trade-offs should be explicit and transparent in antiretroviral policy decisions

A Small Molecule That Binds and Inhibits the ETV1 Transcription Factor Oncoprotein

Members of the ETS transcription factor family have been implicated in several cancers, where they are often dysregulated by genomic derangement. ETS variant 1 (ETV1) is an ETS factor gene that undergoes chromosomal translocation in prostate cancers and Ewing sarcomas, amplification in melanomas, and lineage dysregulation in gastrointestinal stromal tumors. Pharmacologic perturbation of ETV1 would be appealing in these cancers; however, oncogenic transcription factors are often deemed “undruggable” by conventional methods. Here, we used small-molecule microarray screens to identify and characterize drug-like compounds that modulate the biologic function of ETV1. We identified the 1,3,5-triazine small molecule BRD32048 as a top candidate ETV1 perturbagen. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. Moreover, BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation. These results point to a new avenue for pharmacologic ETV1 inhibition and may inform a general means to discover small molecule perturbagens of transcription factor oncoproteins.National Cancer Institute (U.S.) (Initiative for Chemical Genetics Contract N01-CO-12400)National Cancer Institute (U.S.) (Cancer Target Discovery and Development Network RC2 CA148399

A Small Molecule that Binds and Inhibits the ETV1 Transcription Factor Oncoprotein

Members of the ETS transcription factor family have been implicated in several cancers, where they are often dysregulated by genomic derangement. ETS variant 1 (ETV1) is an ETS factor gene that undergoes chromosomal translocation in prostate cancers and Ewing\u27s sarcomas, amplification in melanomas, and lineage dysregulation in gastrointestinal stromal tumors. Pharmacologic perturbation of ETV1 would be appealing in these cancers; however, oncogenic transcription factors are often deemed “undruggable” by conventional methods. Here, we used small-molecule microarray (SMM) screens to identify and characterize drug-like compounds that modulate the biological function of ETV1. We identified the 1,3,5-triazine small molecule BRD32048 as a top candidate ETV1 perturbagen. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. Moreover, BRD32048 inhibits p300-dependent acetylation of ETV1, thereby promoting its degradation. These results point to a new avenue for pharmacological ETV1 inhibition and may inform a general means to discover small molecule perturbagens of transcription factor oncoproteins

Prenatal weight and regional body composition trajectories and neonatal body composition: The NICHD Foetal Growth Studies.

BackgroundGestational weight gain (GWG) and anthropometric trajectories may affect foetal programming and are potentially modifiable.ObjectivesTo assess concomitant patterns of change in weight, circumferences and adiposity across gestation as an integrated prenatal exposure, and determine how they relate to neonatal body composition.MethodsData are from a prospective cohort of singleton pregnancies (n = 2182) enrolled in United States perinatal centres, 2009-2013. Overall and by prepregnancy BMI group (overweight/obesity and healthy weight), joint latent trajectory models were fit with prenatal weight, mid-upper arm circumference (MUAC), triceps (TSF) and subscapular (SSF) skinfolds. Differences in neonatal body composition by trajectory class were assessed via weighted least squares.ResultsSix trajectory patterns reflecting co-occurring changes in weight and MUAC, SSF and TSF across pregnancy were identified overall and by body mass index (BMI) group. Among people with a healthy weight BMI, some differences were observed for neonatal subcutaneous adipose tissue, and among individuals with overweight/obesity some differences in neonatal lean mass were found. Neonatal adiposity measures were higher among infants born to individuals with prepregnancy overweight/obesity.ConclusionsSix integrated trajectory patterns of prenatal weight, subcutaneous adipose tissue and circumferences were observed that were minimally associated with neonatal body composition, suggesting a stronger influence of prepregnancy BMI