Interrelationships Between the Posterior Pharyngeal Space and the Dento-Maxillary Anomalies

Introduction: Nocturnal breathing problems have become more common and cause problems during the day for both those affected by this condition and those around them. These problems are caused in most cases by a decrease in the size of the pharyngeal posterior space, which is associated with various abnormalities of the facial skeleton, and the positioning of the tongue. Purpose: The present study has the purpose to determine the existence of a correlation between different facial skeletal abnormalities and the size of the pharyngeal posterior space. Materials and methods: In the present study we performed the analysis of 131 teleradiographs from the database of the department of orthodontics and dentofacial orthopedics within UMFST “Târgu Mureș” performed on patients in order to perform an orthodontic treatment. Patients range in age from 10 to 21 years. Results: To observe the existence of a link between the median differences in values in the lower pharyngeal space between class I and class II, we used the Mann-Whitney U test to compare median values. Thus, the median value in class I is 0, while the median value in class II is 0.3. It was concluded that this difference is statistically significant (p = 0.02). Conclusion: Patients with skeletal class II have smaller dimensions of the lower pharyngeal space than patients with class I and class III. Patients with skeletal class II have an increased risk compared to those with class I or class III of developing obstructive sleep apnea-hypopnea syndrome during their lifetime

3D-QSAR Design of New Escitalopram Derivatives for the Treatment of Major Depressive Disorders

Antidepressants are psychiatric agents used for the treatment of different types of depression being at present amongst the most commonly prescribed drug, while their effectiveness and adverse effects are the subject of many studies and competing claims. Having studied five QSAR models predicting the biological activities of 18 antidepressants, already approved for clinical treatment, in interaction with the serotonin transporter (SERT), we attempted to establish the membrane ions’ contributions (sodium, potassium, chlorine and calcium) supplied by donor/acceptor hydrogen bond character and electrostatic field to the antidepressant activity. Significant cross-validated correlation q2 (0.5–0.6) and the fitted correlation r2 (0.7–0.82) coefficients were obtained indicating that the models can predict the antidepressant activity of compounds. Moreover, considering the contribution of membrane ions (sodium, potassium and calcium) and hydrogen bond donor character, we have proposed a library of 24 new escitalopram structures, some of them probably with significantly improved antidepressant activity in comparison with the parent compound

Clinical and Experimental Biomechanical Studies Regarding Innovative Implants in Traumatology

Fracture treatment has experienced a fascinating evolution in the last years. The aim of this chapter is to reveal some clinical and biomechanical studies regarding innovative implants. After a short introduction (1), we intend to present our results regarding (2) dynamic condylar screw versus condylar blade plate in complex supracondylar femoral fractures; (3) biomechanical analysis of four types of implants in humeral fractures; (4) clinical and experimental studies for optimal stabilization of trochanteric fractures: the gliding nail; (5) intramedullary XS nail for pilon and ankle fractures: design, biomechanics, and clinical results; (6) the XS nail for the treatment of patella and olecranon fractures; and (7) plates with polyaxial stability for fractures of distal radius and proximal humerus. In conclusion, the authors highlight the advantages of these innovative implants in difficult trauma cases

Size, Number, and Distribution of Thyroid Nodules and the Risk of Malignancy in Radiation-Exposed Patients Who Underwent Surgery

Context: The chance that a thyroid nodule is malignant is higher when there is a history of childhood radiation exposure

Multivariable Intelligent Control for M.A.G. Welding Process

A neural control technique, applied to the MAG (Metal-Active Gas) welding process, is presented in the paper. The static nonlinear model of welding process is based on experimental determinations. The geometric parameters of the welding beam are considered as output parameters of the MAG process (Bs, a, p), and they are measured for different step-variations of the input parameters (Ve, Vs, Ua). The analysis of the output dynamics was further used to model the MAG welding process using a 3- layer neural network with 6 hidden-layer neurons. In order to reject perturbations and cancel the stationary error, an error compensator was used, which consists of the reversedynamic model connected to a proportional integrator controller. imulation results for the multivariable neural controller are presented

Croissance et caractérisation des couches minces d'hydroxyapatite obtenues par la méthode de dépôt laser pulsé (PLD)

STRASBOURG-Sc. et Techniques (674822102) / SudocSudocFranceF

Lipid effects of endocrine medications.

Various alterations of lipid homeostasis have a significant role in the pathophysiology of the artherosclerotic process. The effects of usual lipid-lowering agents such as statins, fibrates, or niacin are well known, but other endocrine therapeutic agents could also affect the blood levels of various lipoproteins and, in turn, influence atheroma formation. In this review, we attempt to summarize the effect of several hormonal and non-hormonal endocrine agents on lipid metabolism, including insulin, thyroid hormone, sex hormones, glucocorticoids, growth hormone, and several anti-diabetic agents

Role of biomarkers in predicting the occurrence of thyroid neoplasms in radiation-exposed children

With increasing numbers of childhood cancer survivors who were treated with radiation, there is a need to evaluate potential biomarkers that could signal an increased risk of developing thyroid cancer. We aimed to examine the relationships between thyrotropin and thyroglobulin levels and the risk of developing thyroid nodules and cancer in a cohort of radiation exposed children. 806 subjects who were irradiated in the neck area as children were examined and followed for up to 25 years. All subjects underwent a clinical examination, measurements of thyrotropin, thyroglobulin levels and thyroid imaging. At baseline, 216 subjects had thyroid nodules and 548 did not. Of those with nodules, 176 underwent surgery with 55 confirmed thyroid cancers. During the follow-up, 147 subjects developed thyroid nodules including 22 with thyroid cancer. Thyroglobulin levels were higher in subjects with prevalent thyroid nodules (26.1 ng/mL vs 9.37 ng/mL; p <0.001) and in those who had an initial normal exam but later developed thyroid nodules (11.2 ng/mL vs 8.87 ng/mL; p=0.017). There was no relationship between baseline thyrotropin levels and the prevalent presence or absence of thyroid nodules, whether a prevalent neoplasm was benign or malignant, subsequent development of thyroid nodules during follow-up, or whether an incident nodule was benign or malignant. In conclusion, in radiation exposed children, higher thyroglobulin levels indicated an increased risk of developing thyroid nodules but did not differentiate between benign and malignant neoplasms. There was no association between the baseline thyrotropin level and the risk of developing thyroid nodules or cancer