Different factors influencing Deha Prakriti (constitution) and influenced by Prakriti (constitution)

Complete psychosomatic architect of an individual is represented by his Prakriti (constitution) which starts to take shape at the very first step of conception in mother’s womb. Deeds of previous incarnation, physical and psychological state of mother and father during conception, nutrition and regimen of mother, social melue, practice of wholesomeness by mother (during pregnancy) and child in postnatal period and many more factors are attributed in the Prakriti formation. Thus generated Prakriti helps in understanding the health and disease state of an individual and facilitate in promotive and curative aspects. Not only this, inherited psycho constution (Manasik Prakriti) is also very helpful in prediction and deciding the profession, effectiveness and efficiency evaluation too. Management education sector, Life and Health insurance sectors are now showing a keen interest in incorporating concept of Prakriti (constitution) in their business. Genomic relations of Prakriti concept of Ayurveda in the recent researches in India and abroad has established the facts that the difference in genomic make up is responsible for all variations in health and disease state of life which we have analyzed and summarized in this review. In the present literary research paper all the factors which influence the Prakriti are enumerated in classified manner and different types of psychosomatic contributions are detailed along with their effect on health and disease condition of life as well as preventive and promotive aspects

Concept of Sushrutokta Guda Shareera

Swastha Rakshana and Vikara Prashamana are the prime goals of Ayurveda. Knowledge about structural and functional aspect of Shareera is considered as a key to reach these goals. Guda is one such structural entity explained in Ayurveda, which play a role in elimination of Pureesha and Apana Vata. In Basti Chikitsa, one of the prime treatment modality of Vata medicine usually administered through Guda Marga only. Hence knowledge of Guda is helpful in understanding the physiology of Pureesha Bahirgamana and concept of Basti Chikitsa. In this article an attempt is made to understand the concept of Sushrutokta Guda Shareera

A bird’s eye view on Kesha (hair) in Charaka Samhita

Ayurveda is a Tantra which mainly aims at preserving the health of an individual and to treat the illness of a patient. The structure and function of bodily entities vary in health and disease conditions accordingly. The study of these structures acts as a yardstick to understand the health and illness of a person. One such indicator of health or disease is hair (Kesha). Kesha being one such parameter of health, description about it regarding its formation, characteristics, variation according to different body constitution (Prakruti), beneficial and harmful factors for Kesha, its maintenance, importance in clinical diagnosis and prognosis of a disease etc. is available in Ayurveda. In this article, an attempt is made to understand Kesha Sharira according to Charaka Samhita

Health of Urban Women with Respect of HIV Infection: A Case Study in Dakshina Kannada

In Human Immuno-deficiency Virus and Acquired Immuno-Deficiency Syndrome (HIV/AIDS), the HIV virus attacks the immune system, which defends the human body against pathogens. When there is balance against the immune system, the people living with HIV/AIDS (PLHA) become more susceptible to opportunistic infections (OIs). With the bodies immune system is not capable of defending itself against Opportunistic Infections, the PLHA ultimately submit to them. In developed countries, the cost of antiretroviral (ARVs) has been borne completely by the state; as a result, there has been a decrease in the number of deaths on account of HIV in the past 15 years. On the other hand, the number of deaths in developing countries due to HIV continues. In this paper, the researchers have made an attempt to examine the status of health of women in urban areas with respect to HIV infection. With this specific aim tried to know the reasons for the HIV/AIDs infection and its effect, consequence on women health particularly. By adopting field survey, interview and case studies methods, 50 samples have been taken and analyzed them systematically

Study on Pramana Shareera in relation to Prakriti

Ayurveda in its principle has given importance to individualistic approach rather than generalize. Application of this examination can be clearly seem like even though two patients suffering from same disease, the treatment modality may change depending upon the results of Dashvidha Pariksha. Prakruti and Pramana both used in Dashvidha Pariksha. Both determine the health of the individual and Bala (strength) of Rogi (Patient). Ayurveda followed Swa-angula Pramana as the unit of measurement for measuring the different parts of the body which is prime step assessing patient before treatment. Sushruta and Charaka had stated different Angula Pramana of each Pratyanga (body parts). Specificity is the characteristic property of Swa-angula Pramana. This can be applicable in present era for example artificial limbs. A scientific research includes collection, compilation, analysis and lastly scrutiny of entire findings to arrive at a conclusion. Study of Pramana and its relation with Prakruti was conducted in 1000 volunteers using Prakruti Parkishan proforma with an objective of evaluation of Anguli Pramana in various Prakriti. It was observed co-relating Pramana in each Prakruti and Granthokta Pramana that there is no vast difference in measurement of head, upper limb and lower limb. The observational study shows closer relation of features with classical texts

Importance of Pramana Pareeksha in Clinical Practice

In Ayurveda the term Pareeksha is used in place of Pramana. The synonyms of Pareeksha are Pramana, Saadana, Jnana, Upalabdhi. Pariksha means through which investigation cognition of valid apprehension of the state of the object arise is called Pariksha. Which is investigated in depth, establishment of reality of an object is Pareeksha. “Rogamadou Pareekshet Tathonantaram Aoushadam” it is very essential that before planning any treatment one should have complete knowledge of Roga and Rogibala. The purpose of examination is to obtain knowledge regarding span of life, strength and intensity of morbidity. Hence patient to be examined in respect of Prakruti (constitution of body), Vikruti (pathological examination), Sara (examination of elemental tissue and mind), Samhana (examination of compactness of body), Pramana (measurement), Satmya (suitability), Satva (examination of mental constitution), Aaharashakti (examination of digestive power), Vyayamashakti (examination of strength by exercise), Vaya (examination of age). Among these Dashavidha Pareeksha except Vikruti Pareeksha is to be done to understand the overview condition of the person. Vikrutipariksha is to be done to elicit the factors which are responsible for the pathogenesis of the diseases

A STUDY ON THE CHALLENGES OF HIV POSITIVE CHILDREN IN DAKSHINA KANNADA

Human Immuno-deficiency Virus and Acquired Immuno-Deficiency Syndrome (HIV/AIDS) epidemic carries with it the forces of destructions. Children are infected with HIV/AIDS through their parents by birth. Children are brought in the families where the situation is such either their parents are ill or they are single parent or orphan. Parents no longer hold jobs, families lose their breadwinners and they use their time and money to care for ill members. This situation has effects on the children’s education leads them to discontinue education because of the financial needs of the family. Same situation has been faced by the HIV negative children affected by HIV. Both infected and affected children have to face discrimination from various angles. The main aim of this research is to study the challenges faced by HIV positive children. And the objectives are to study the condition and the problems faced by the positive children and the measures to overcome the difficulties are discussed by the researcher. The information collected by using both from primary and secondary method. Interview is conducted and selected 50 samples and 10 case studies. (1, 3

Examining the Role of Usability, Compatibility and Social Influence in Mobile Banking Adoption in Indonesia

Adaptation to the internet and advances in mobile technology has become key to the survival of industries, including the banking industry. One of the latest electronic banking channels is mobile banking. While mobile banking offers various advantages, many banks in Indonesia are facing the problem of low adoption. This paper reports on the findings of our research project, which examines mobile banking adoption behavior in Indonesia from an interaction perspective. Specifically, the paper examines the role of usability, compatibility and social influence in explaining people’s intention to continue using mobile banking in Indonesia. Using an interaction perspective framework, a research model is proposed. Ten hypotheses are suggested, examining six constructs: satisfaction, perceived usefulness, perceived ease of use, perceived learnability, compatibility and social influence. From a theoretical perspective, this paper is the first to combine usability, compatibility and social influence in a mobile banking adoption study. Data from 319 valid respondents were used to test the proposed model using partial least squares structural equation modeling. The results show that all the hypotheses are supported, and it was found that people’s intention to continue using mobile banking is significantly affected by satisfaction, compatibility, perceived usefulness, perceived learnability and social influence

An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

<p>Abstract</p> <p>Background</p> <p><it>In vitro </it>cell systems together with omics methods represent promising alternatives to conventional animal models for toxicity testing. Transcriptomic and proteomic approaches have been widely applied <it>in vitro </it>but relatively few studies have used metabolomics. Therefore, the goal of the present study was to develop an untargeted methodology for performing reproducible metabolomics on <it>in vitro </it>systems. The human liver cell line HepG2, and the well-known hepatotoxic and non-genotoxic carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), were used as the <it>in vitro </it>model system and model toxicant, respectively.</p> <p>Results</p> <p>The study focused on the analysis of intracellular metabolites using NMR, LC-MS and GC-MS, with emphasis on the reproducibility and repeatability of the data. State of the art pre-processing and alignment tools and multivariate statistics were used to detect significantly altered levels of metabolites after exposing HepG2 cells to TCDD. Several metabolites identified using databases, literature and LC-nanomate-Orbitrap analysis were affected by the treatment. The observed changes in metabolite levels are discussed in relation to the reported effects of TCDD.</p> <p>Conclusions</p> <p>Untargeted profiling of the polar and apolar metabolites of <it>in vitro </it>cultured HepG2 cells is a valid approach to studying the effects of TCDD on the cell metabolome. The approach described in this research demonstrates that highly reproducible experiments and correct normalization of the datasets are essential for obtaining reliable results. The effects of TCDD on HepG2 cells reported herein are in agreement with previous studies and serve to validate the procedures used in the present work.</p

Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan

Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed populations from the Framingham Heart Study (FHS) original and offspring cohorts and the Long Life Family Study (LLFS) to investigate gender-specific effects of the ApoE4 allele on human survival in a wide range of ages from midlife to extreme old ages, and the sensitivity of these effects to cardiovascular disease (CVD), cancer, and neurodegenerative disorders (ND). The analyses show that women's lifespan is more sensitive to the e4 allele than men's in all these populations. A highly significant adverse effect of the e4 allele is limited to women with moderate lifespan of about 70 to 95 years in two FHS cohorts and the LLFS with relative risk of death RR = 1.48 (p = 3.6×10(−6)) in the FHS cohorts. Major human diseases including CVD, ND, and cancer, whose risks can be sensitive to the e4 allele, do not mediate the association of this allele with lifespan in large FHS samples. Non-skin cancer non-additively increases mortality of the FHS women with moderate lifespans increasing the risks of death of the e4 carriers with cancer two-fold compared to the non-e4 carriers, i.e., RR = 2.07 (p = 5.0×10(−7)). The results suggest a pivotal role of non-sex-specific cancer as a nonlinear modulator of survival in this sample that increases the risk of death of the ApoE4 carriers by 150% (p = 5.3×10(−8)) compared to the non-carriers. This risk explains the 4.2 year shorter life expectancy of the e4 carriers compared to the non-carriers in this sample. The analyses suggest the existence of age- and gender-sensitive systemic mechanisms linking the e4 allele to lifespan which can non-additively interfere with cancer-related mechanisms