Complete psychosomatic architect of an individual is represented by his Prakriti (constitution) which starts to take shape at the very first step of conception in mother’s womb. Deeds of previous incarnation, physical and psychological state of mother and father during conception, nutrition and regimen of mother, social melue, practice of wholesomeness by mother (during pregnancy) and child in postnatal period and many more factors are attributed in the Prakriti formation. Thus generated Prakriti helps in understanding the health and disease state of an individual and facilitate in promotive and curative aspects. Not only this, inherited psycho constution (Manasik Prakriti) is also very helpful in prediction and deciding the profession, effectiveness and efficiency evaluation too. Management education sector, Life and Health insurance sectors are now showing a keen interest in incorporating concept of Prakriti (constitution) in their business. Genomic relations of Prakriti concept of Ayurveda in the recent researches in India and abroad has established the facts that the difference in genomic make up is responsible for all variations in health and disease state of life which we have analyzed and summarized in this review. In the present literary research paper all the factors which influence the Prakriti are enumerated in classified manner and different types of psychosomatic contributions are detailed along with their effect on health and disease condition of life as well as preventive and promotive aspects