145 research outputs found
Improving the distances of post-AGB objects in the Milky Way
Conference Theme: Physics and Chemistry of the Late Stages of Stellar EvolutionPost-AGB (PAGB) stars are short-lived, low-intermediate mass objects transitioning from the asymptotic giant branch (AGB) to the white dwarf (WD) phase. These objects are characterised by a constant, core-mass dependent luminosity and a large infrared excess from the dusty envelope ejected at the top of the AGB. PAGB stars provide insights into the evolution of their direct descendants, planetary nebulae (PNe). Calculation of physical characteristics of PAGB are dependent on accurately determined distances scarcely available in the literature. Using the Torun catalogue for PAGB objects, supplemented with archival data, we have determined distances to the known population of Galactic PAGB stars. This is by modelling their spectral energy distributions (SED) with black bodies and numerically integrating over the entire wavelength range to determine the total integrated object flux. For most PAGB stars we assumed their luminosities are based on their positional characteristics and stellar evolution models. RV Tauri stars however are known to follow a period-luminosity relation (PLR) reminiscent of type-2 Cepheids. For these variable PAGB stars we determined their luminosities via the PLR and hence their distances. This allows us to overcome the biggest obstacle to characterising these poorly understood objects that play a vital part in Galactic chemical enrichment.postprin
BINARY CENTRAL STARS OF PLANETARY NEBULAE DISCOVERED THROUGH PHOTOMETRIC VARIABILITY. V. THE CENTRAL STARS OF HaTr 7 AND ESO 330-9
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Light echoes reveal an unexpectedly cool Eta Carinae during its 19th-century Great Eruption
Eta Carinae (Eta Car) is one of the most massive binary stars in the Milky
Way. It became the second-brightest star in the sky during its mid-19th century
"Great Eruption," but then faded from view (with only naked-eye estimates of
brightness). Its eruption is unique among known astronomical transients in that
it exceeded the Eddington luminosity limit for 10 years. Because it is only 2.3
kpc away, spatially resolved studies of the nebula have constrained the ejected
mass and velocity, indicating that in its 19th century eruption, Eta Car
ejected more than 10 M_solar in an event that had 10% of the energy of a
typical core-collapse supernova without destroying the star. Here we report the
discovery of light echoes of Eta Carinae which appear to be from the 1838-1858
Great Eruption. Spectra of these light echoes show only absorption lines, which
are blueshifted by -210 km/s, in good agreement with predicted expansion
speeds. The light-echo spectra correlate best with those of G2-G5 supergiant
spectra, which have effective temperatures of ~5000 K. In contrast to the class
of extragalactic outbursts assumed to be analogs of Eta Car's Great Eruption,
the effective temperature of its outburst is significantly cooler than allowed
by standard opaque wind models. This indicates that other physical mechanisms
like an energetic blast wave may have triggered and influenced the eruption.Comment: Accepted for publication by Nature; 4 pages, 4 figures, SI: 6 pages,
3 figures, 5 table
The use of a Psoroptes ovis serodiagnostic test for the analysis of a natural outbreak of sheep scab
<p>Abstract</p> <p>Background</p> <p>Sheep scab is a highly contagious disease of sheep caused by the ectoparasitic mite <it>Psoroptes ovis</it>. The disease is endemic in the UK and has significant economic impact through its effects on performance and welfare. Diagnosis of sheep scab is achieved through observation of clinical signs e.g. itching, pruritis and wool loss and ultimately through the detection of mites in skin scrapings. Early stages of infestation are often difficult to diagnose and sub-clinical animals can be a major factor in disease spread. The development of a diagnostic assay would enable farmers and veterinarians to detect disease at an early stage, reducing the risk of developing clinical disease and limiting spread.</p> <p>Methods</p> <p>Serum samples were obtained from an outbreak of sheep scab within an experimental flock (n = 480 (3 samples each from 160 sheep)) allowing the assessment, by ELISA of sheep scab specific antibody prior to infestation, mid-outbreak (combined with clinical assessment) and post-treatment.</p> <p>Results</p> <p>Analysis of pre-infestation samples demonstrated low levels of potential false positives (3.8%). Of the 27 animals with clinical or behavioural signs of disease 25 tested positive at the mid-outbreak sampling period, however, the remaining 2 sheep tested positive at the subsequent sampling period. Clinical assessment revealed the absence of clinical or behavioural signs of disease in 132 sheep, whilst analysis of mid-outbreak samples showed that 105 of these clinically negative animals were serologically positive, representing potential sub-clinical infestations.</p> <p>Conclusions</p> <p>This study demonstrates that this ELISA test can effectively diagnose sheep scab in a natural outbreak of disease, and more importantly, highlights its ability to detect sub-clinically infested animals. This ELISA, employing a single recombinant antigen, represents a major step forward in the diagnosis of sheep scab and may prove to be critical in any future control program.</p
Validity of willingness to pay measures under preference uncertainty
This paper is part of the project ACCEPT, which is funded by the German Federal Ministry for Education and Research (grant number 01LA1112A). The publication of this article was funded by the Open Access fund of the Leibniz Association. All data is available on the project homepage (https://www.ifw-kiel.de/forschung/umwelt/projekte/accept) and from Figshare (https://dx.doi.org/10.6084/m9.figshare.3113050.v1).Recent studies in the marketing literature developed a new method for eliciting willingness to pay (WTP) with an open-ended elicitation format: the Range-WTP method. In contrast to the traditional approach of eliciting WTP as a single value (Point-WTP), Range-WTP explicitly allows for preference uncertainty in responses. The aim of this paper is to apply Range-WTP to the domain of contingent valuation and to test for its theoretical validity and robustness in comparison to the Point-WTP. Using data from two novel large-scale surveys on the perception of solar radiation management (SRM), a little-known technique for counteracting climate change, we compare the performance of both methods in the field. In addition to the theoretical validity (i.e. the degree to which WTP values are consistent with theoretical expectations), we analyse the test-retest reliability and stability of our results over time. Our evidence suggests that the Range-WTP method clearly outperforms the Point-WTP method.Publisher PDFPeer reviewe
Geography, private costs and uptake of screening for abdominal aortic aneurysm in a remote rural area
BACKGROUND: The relationship between geographical location, private costs, health provider costs and uptake of health screening is unclear. This paper examines these relationships in a screening programme for abdominal aortic aneurysm in the Highlands and Western Isles of Scotland, a rural and remote area of over 10,000 square miles. METHODS: Men aged 65–74 (n = 9323) were invited to attend screening at 51 locations in 50 settlements. Effects of geography, deprivation and age on uptake were examined. Among 8,355 attendees, 8,292 completed a questionnaire detailing mode of travel and costs incurred, time travelled, whether accompanied, whether dependants were cared for, and what they would have been doing if not attending screening, thus allowing private costs to be calculated. Health provider (NHS) costs were also determined. Data were analysed by deprivation categories, using the Scottish Indices of Deprivation (2003), and by settlement type ranging from urban to very remote rural. RESULTS: Uptake of screening was high in all settlement types (mean 89.6%, range 87.4 – 92.6%). Non-attendees were more deprived in terms of income, employment, education and health but there was no significant difference between non-attendees and attendees in terms of geographical access to services. Age was similar in both groups. The highest private costs (median £7.29 per man) and NHS screening costs (£18.27 per man invited) were observed in very remote rural areas. Corresponding values for all subjects were: private cost £4.34 and NHS cost £15.72 per man invited. CONCLUSION: Uptake of screening for abdominal aortic aneurysm in this remote and rural setting was high in comparison with previous studies, and this applied across all settlement types. Geographical location did not affect uptake, most likely due to the outreach approach adopted. Private and NHS costs were highest in very remote settings but still compared favourably with other published studies
Enhancing apoptosis in TRAIL-resistant cancer cells using fundamental response rules
The tumor necrosis factor related apoptosis-inducing ligand (TRAIL) induces apoptosis
in malignant cells, while leaving other cells mostly unharmed. However, several
carcinomas remain resistant to TRAIL. To investigate the resistance mechanisms in
TRAIL-stimulated human fibrosarcoma (HT1080) cells, we developed a computational
model to analyze the temporal activation profiles of cell survival (IκB, JNK, p38)
and apoptotic (caspase-8 and -3) molecules in wildtype and several (FADD, RIP1,
TRAF2 and caspase-8) knock-down conditions. Based on perturbation-response approach
utilizing the law of information (signaling flux) conservation, we derived response
rules for population-level average cell response. From this approach, i) a
FADD-independent pathway to activate p38 and JNK, ii) a crosstalk between RIP1 and
p38, and iii) a crosstalk between p62 and JNK are predicted. Notably, subsequent
simulations suggest that targeting a novel molecule at p62/sequestosome-1 junction
will optimize apoptosis through signaling flux redistribution. This study
offers a valuable prospective to sensitive TRAIL-based therapy
Seasonal influenza vaccination in pregnant women: knowledge, attitudes, and behaviors in Italy
Complete Phenotypic Recovery of an Alzheimer's Disease Model by a Quinone-Tryptophan Hybrid Aggregation Inhibitor
The rational design of amyloid oligomer inhibitors is yet an unmet drug development need. Previous studies have identified the role of tryptophan in amyloid recognition, association and inhibition. Furthermore, tryptophan was ranked as the residue with highest amyloidogenic propensity. Other studies have demonstrated that quinones, specifically anthraquinones, can serve as aggregation inhibitors probably due to the dipole interaction of the quinonic ring with aromatic recognition sites within the amyloidogenic proteins. Here, using in vitro, in vivo and in silico tools we describe the synthesis and functional characterization of a rationally designed inhibitor of the Alzheimer's disease-associated β-amyloid. This compound, 1,4-naphthoquinon-2-yl-L-tryptophan (NQTrp), combines the recognition capacities of both quinone and tryptophan moieties and completely inhibited Aβ oligomerization and fibrillization, as well as the cytotoxic effect of Aβ oligomers towards cultured neuronal cell line. Furthermore, when fed to transgenic Alzheimer's disease Drosophila model it prolonged their life span and completely abolished their defective locomotion. Analysis of the brains of these flies showed a significant reduction in oligomeric species of Aβ while immuno-staining of the 3rd instar larval brains showed a significant reduction in Aβ accumulation. Computational studies, as well as NMR and CD spectroscopy provide mechanistic insight into the activity of the compound which is most likely mediated by clamping of the aromatic recognition interface in the central segment of Aβ. Our results demonstrate that interfering with the aromatic core of amyloidogenic peptides is a promising approach for inhibiting various pathogenic species associated with amyloidogenic diseases. The compound NQTrp can serve as a lead for developing a new class of disease modifying drugs for Alzheimer's disease
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The tenth data release of the Sloan digital sky survey: First spectroscopic data from the SDSS-iii apache point observatory galactic evolution experiment
The Sloan Digital Sky Survey (SDSS) has been in operation since 2000 April. This paper presents the tenth public data release (DR10) from its current incarnation, SDSS-III. This data release includes the first spectroscopic data from the Apache Point Observatory Galaxy Evolution Experiment (APOGEE), along with spectroscopic data from the Baryon Oscillation Spectroscopic Survey (BOSS) taken through 2012 July. The APOGEE instrument is a near-infrared R ~ 22,500 300-fiber spectrograph covering 1:514-1:696 μm. The APOGEE survey is studying the chemical abundances and radial velocities of roughly 100,000 red giant star candidates in the bulge, bar, disk, and halo of the Milky Way. DR10 includes 178,397 spectra of 57,454 stars, each typically observed three or more times, from APOGEE. Derived quantities from these spectra (radial velocities, effective temperatures, surface gravities, and metallicities) are also included.
DR10 also roughly doubles the number of BOSS spectra over those included in the ninth data release. DR10 includes a total of 1,507,954 BOSS spectra, comprising 927,844 galaxy spectra; 182,009 quasar spectra; and 159,327 stellar spectra, selected over 6373.2 deg2.This is an author-created, un-copyedited version of an article accepted for publication in The Astrophysical Journal Supplement Series. The publisher is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at http://dx.doi.org/10.1088/0067-0049/211/2/17. The accepted version will be under embargo until the 18th March 2015
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