2,556 research outputs found
Magnetic field induced 3D to 1D crossover in type II superconductors
We review and analyze magnetization and specific heat investigations on
type-II superconductors which uncover remarkable evidence for the magnetic
field induced fnite size effect and the associated 3D to 1D crossover which
enhances thermal fluctuations.Comment: 26 pages, 19 figure
Personalized cancer medicine and the future of pathology
In February 2011, a group of pathologists from different departments in Europe met in Zurich, Switzerland, to discuss opportunities and challenges for pathology in the era of personalized medicine. The major topics of the meeting were assessment of the role of pathology in personalized medicine, its future profile among other biomedical disciplines with an interest in personalized medicine as well as the evolution of companion diagnostics. The relevance of novel technologies for genome analysis in clinical practice was discussed. The participants recognize that there should be more initiatives taken by the pathology community in companion diagnostics and in the emerging field of next-generation sequencing and whole genome analysis. The common view of the participants was that the pathology community has to be mobilized for stronger engagement in the future of personalized medicine. Pathologists should be aware of the challenges and the analytical opportunities of the new technologies. Challenges of clinical trial design as well as insurance and reimbursement questions were addressed. The pathology community has the responsibility to lead medical colleagues into embracing this new area of genomic medicine. Without this effort, the discipline of pathology risks losing its key position in molecular tissue diagnostic
ESMO recommendations on the standard methods to detect NTRK fusions in daily practice and clinical research
Abstract Background NTRK1, NTRK2 and NTRK3 fusions are present in a plethora of malignancies across different histologies. These fusions represent the most frequent mechanism of oncogenic activation of these receptor tyrosine kinases, and biomarkers for the use of TRK small molecule inhibitors. Given the varying frequency of NTRK1/2/3 fusions, crucial to the administration of NTRK inhibitors is the development of optimal approaches for the detection of human cancers harbouring activating NTRK1/2/3 fusion genes. Materials and methods Experts from several Institutions were recruited by the European Society for Medical Oncology (ESMO) Translational Research and Precision Medicine Working Group (TR and PM WG) to review the available methods for the detection of NTRK gene fusions, their potential applications, and strategies for the implementation of a rational approach for the detection of NTRK1/2/3 fusion genes in human malignancies. A consensus on the most reasonable strategy to adopt when screening for NTRK fusions in oncologic patients was sought, and further reviewed and approved by the ESMO TR and PM WG and the ESMO leadership. Results The main techniques employed for NTRK fusion gene detection include immunohistochemistry, fluorescence in situ hybridization (FISH), RT-PCR, and both RNA-based and DNA-based next generation sequencing (NGS). Each technique has advantages and limitations, and the choice of assays for screening and final diagnosis should also take into account the resources and clinical context. Conclusion In tumours where NTRK fusions are highly recurrent, FISH, RT-PCR or RNA-based sequencing panels can be used as confirmatory techniques, whereas in the scenario of testing an unselected population where NTRK1/2/3 fusions are uncommon, either front-line sequencing (preferentially RNA-sequencing) or screening by immunohistochemistry followed by sequencing of positive cases should be pursued
Modification of the rho meson detected by low-mass electron-positron pairs in central Pb-Au collisions at 158 A GeV/c
We present a measurement of pair production in central Pb-Au
collisions at 158 GeV/. As reported earlier, a significant excess of the
pair yield over the expectation from hadron decays is observed. The
improved mass resolution of the present data set, recorded with the upgraded
CERES experiment at the CERN-SPS, allows for a comparison of the data with
different theoretical approaches. The data clearly favor a substantial
in-medium broadening of the spectral function over a density-dependent
shift of the pole mass. The in-medium broadening model implies that
baryon induced interactions are the key mechanism to in-medium modifications of
the -meson in the hot fireball at SPS energy.Comment: Revised versio
Event-by-event fluctuations at SPS
Results on event-by-event fluctuations of the mean transverse momentum and
net charge in Pb-Au collisions, measured by the CERES Collaboration at
CERN-SPS, are presented. We discuss the centrality and beam energy dependence
and compare our data to cascade calculations.Comment: 4 pages, 4 figures, proceedings to INPC2004 Goteborg, Swede
New Results on Pb-Au Collisions at 40 AGeV from the CERES/NA45 Experiment
In 1999 the CERES/NA45 ran at the CERN SPS with a beam energy of 40
GeV/nucleon. The data set comprises about 8.7 millions Pb-Au events with a
trigger selection corresponding to approximately the most central 30% of the
geometrical cross section. Results on low-mass electron pair analysis are
presented.
The upgrade of the experimental setup with the radial drift TPC has allowed
to enhance hadron physics capabilities of the experiment. New results on hadron
spectra (including Lambda) and flow are presented.Comment: Talk at the International Nuclear Physics Conference INPC2001,
Berkeley, CA, July 29th - August 3rd 200
Lambda production in 40 A GeV/c Pb-Au collisions
During the 1999 lead run, CERES has measured hadron and electron-pair
production at 40 A GeV/c beam momentum with the spectrometer upgraded by the
addition of a radial TPC. Here the analysis of lambda and antilambda will be
presented.Comment: 8 pages, 8 figures. 6th International Conference on Strange Quarks in
Matter, Frankfurt 200
Leptonic and charged kaon decay modes of the meson measured in heavy-ion collisions at the CERN SPS
We report a measurement of meson production in central Pb+Au
collisions at E/A=158 GeV. For the first time in heavy-ion collisions,
mesons were reconstructed in the same experiment both in the KK
and the dilepton decay channel. Near mid-rapidity, this yields rapidity
densities, corrected for production at the same rapidity value, of 2.05 +-
0.14(stat) +- 0.25(syst) and 2.04 +- 0.49(stat)+-{0.32}(syst), respectively.
The shape of the measured transverse momentum spectra is also in close
agreement in both decay channels. The data rule out a possible enhancement of
the yield in the leptonic over the hadronic channel by a factor larger
than 1.6 at 95% CL.Comment: 11 pages, 4 figures,submitted to Phys. Rev. Let
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