122 research outputs found

    291 Cystic fibrosis mortality trend in Italy between 1970 and 2011

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    YOUNG ITALIANS' MEDIA USE AND ATTITUDE TOWARDS IMMIGRATION

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    This paper describes a study aimed at analyzing whether and how certain technologies usage practices can lead to the construction of different perceptions in relation to social phenomena. In particular, the study enquires how the evolution in the way young people get informed, can lead to different attitudes towards a phenomenon such as immigration. The work aims to understand what kind of relationship exists between different media usage types and (over)exposure to the news – made possible by the web, particularly social media – and the perception (in cognitive and evaluative terms) of the presence of immigrants in Italy. To answer these questions, an empirical research was conducted using a qualitative and quantitative approach. In particular, the quantitative study was carried through a survey on a sample of 200 subjects and illustrates how the information system, new information technologies and media consumption strongly influence the way young Italian see the world, confirming a bias between their perception and what statistical data say about the environment in which they are living

    Sopravvivenza e mortalità per causa

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    Analisi della mortalità generale e per causa nelle regioni italian

    On the possibility to utilize a PCO Edge 4.2 bi scientific CMOS imager for extended ultra violet and soft X-ray photon detection

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    A state of the art commercial detector, a PCO Edge 4.2 bi based on a back illuminated sCMOS sensor developed for applications in the visible light/ultra violet regime has been adapted for ultra-high vacuum operations and has been characterized using soft X-ray in the energy range from 30 eV to 1000 eV. The imager features 2048 x 2048 pixel with a pixel size of 6.5 mu m x 6.5 mu m and allows full frame acquisitions at 48 Hz with a dynamic range of 88 dB at a noise level of 1.9 e(-). Spatial resolution and quantum efficiency have been elucidated in the aforementioned energy range at a soft X-ray beam line at Elettra Sincrotrone Trieste. The handiness of the camera as well as its Python library package allows easy and fast integration into the beam line environments of synchrotron sources and free electron lasers

    Hypertrophic Cardiomyopathy in Children: Pathophysiology, Diagnosis, and Treatment of Non-sarcomeric Causes

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    Hypertrophic cardiomyopathy (HCM) is a myocardial disease characterized by left ventricular hypertrophy not solely explained by abnormal loading conditions. Despite its rare prevalence in pediatric age, HCM carries a relevant risk of mortality and morbidity in both infants and children. Pediatric HCM is a large heterogeneous group of disorders. Other than mutations in sarcomeric genes, which represent the most important cause of HCM in adults, childhood HCM includes a high prevalence of non-sarcomeric causes, including inherited errors of metabolism (i.e., glycogen storage diseases, lysosomal storage diseases, and fatty acid oxidation disorders), malformation syndromes, neuromuscular diseases, and mitochondrial disease, which globally represent up to 35% of children with HCM. The age of presentation and the underlying etiology significantly impact the prognosis of children with HCM. Moreover, in recent years, different targeted approaches for non-sarcomeric etiologies of HCM have emerged. Therefore, the etiological diagnosis is a fundamental step in designing specific management and therapy in these subjects. The present review aims to provide an overview of the non-sarcomeric causes of HCM in children, focusing on the pathophysiology, clinical features, diagnosis, and treatment of these rare disorders

    Molecular Basis of Inflammation in the Pathogenesis of Cardiomyopathies

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    Cardiomyopathies (CMPs) represent a diverse group of heart muscle diseases, grouped into specific morphological and functional phenotypes. CMPs are associated with mutations in sarcomeric and non-sarcomeric genes, with several suspected epigenetic and environmental mechanisms involved in determining penetrance and expressivity. The understanding of the underlying molecular mechanisms of myocardial diseases is fundamental to achieving a proper management and treatment of these disorders. Among these, inflammation seems to play an important role in the pathogenesis of CMPs. The aim of the present study is to review the current knowledge on the role of inflammation and the immune system activation in the pathogenesis of CMPs and to identify potential molecular targets for a tailored anti-inflammatory treatment

    Tunability experiments at the FERMI@Elettra free-electron laser

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    FERMI@Elettra is a free electron-laser (FEL)-based user facility that, after two years of commissioning, started preliminary users' dedicated runs in 2011. At variance with other FEL user facilities, FERMI@Elettra has been designed to deliver improved spectral stability and longitudinal coherence. The adopted scheme, which uses an external laser to initiate the FEL process, has been demonstrated to be capable of generating FEL pulses close to the Fourier transform limit. We report on the first instance of FEL wavelength tuning, both in a narrow and in a large spectral range (fine- and coarse-tuning). We also report on two different experiments that have been performed exploiting such FEL tuning. We used fine-tuning to scan across the 1s–4p resonance in He atoms, at ≈23.74 eV (52.2 nm), detecting both UV–visible fluorescence (4p–2s, 400 nm) and EUV fluorescence (4p–1s, 52.2 nm). We used coarse-tuning to scan the M4,5 absorption edge of Ge (∼29.5 eV) in the wavelength region 30–60 nm, measured in transmission geometry with a thermopile positioned on the rear side of a Ge thin foil

    Two-photon resonant excitation of interatomic coulombic decay in neon dimers

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    The recent availability of intense and ultrashort extreme ultraviolet sources opens up the possibility of investigating ultrafast electronic relaxation processes in matter in an unprecedented regime. In this work we report on the observation of two-photon excitation of interatomic Coulombic decay (ICD) in neon dimers using the tunable intense pulses delivered by the free electron laser FERMI. The unique characteristics of FERMI (narrow bandwidth, spectral stability, and tunability) allow one to resonantly excite specific ionization pathways and to observe a clear signature of the ICD mechanism in the ratio of the ion yield created by Coulomb explosion. The present experimental results are explained by ab initio electronic structure and nuclear dynamics calculations

    Effectiveness of flow obstructions in enhancing electro-osmotic flow

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    In this paper the influence of obstructions on micro-channel electroosmotic flow is investigated for the first time. To carry out such a study, regular obstructions are introduced into micro-channels and flow rates are numerically calculated. The effect of channel width on flow rates is analysed on both free and obstructed channels. The solid material considered for channel walls and obstructions is silicon and the electrolyte is de-ionised water. The parameters studied include channel width, obstruction size and effective porosity of the channel. The effective porosity is varied between 0.4 and 0.8 depending on other chosen parameters. The results clearly demonstrate that, under the analysed conditions, introduction of obstructions into channels wider than100 micro meters enhances the flow rate induced by electro-osmosis
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