Colour image processing and texture analysis on images of porterhouse steak meat

This paper outlines two colour image processing and texture analysis techniques applied to meat images and assessment of error due to the use of JPEG compression at image capture. JPEG error analysis was performed by capturing TIFF and JPEG images, then calculating the RMS difference and applying a calibration between block boundary features and subjective visual JPEG scores. Both scores indicated high JPEG quality. Correction of JPEG blocking error was trialled and found to produce minimal improvement in the RMS difference. The texture analysis methods used were singular value decomposition over pixel blocks and complex cell analysis. The block singular values were classified as meat or non- meat by Fisher linear discriminant analysis with the colour image processing result used as ‘truth.’ Using receiver operator characteristic (ROC) analysis, an area under the ROC curve of 0.996 was obtained, demonstrating good correspondence between the colour image processing and the singular values. The complex cell analysis indicated a ‘texture angle’ expected from human inspection

Optical full Hadamard matrix multiplexing and noise effects: errata

The model for Poisson random noise under Hadamard multiplexing is revised. The new model accounts for the variation of the Hadamard multiplexed measurements, as well as the previously considered variation due to Poisson fluctuations. A numerical simulation matches the model prediction within uncertainty

Optical full Hadamard matrix multiplexing and noise effects

Hadamard multiplexing provides a considerable SNR boost over additive random noise but Poisson noise such as photon noise reduces the boost. We develop the theory for full H-matrix Hadamard transform imaging under additive and Poisson noise effects. We show that H-matrix encoding results in no effect on average on the noise level due to Poisson noise sources while preferentially reducing additive noise. We use this result to explain the wavelength-dependent varying SNR boost in a Hadamard hyperspectral imager and argue that such a preferential boost is useful when the main noise source is indeterminant or varying

Tester periodically registers dc amplifier characteristics

Motor-driven switcher-recorder periodically registers the zero drift and gain drift signals of a dc amplifier subjected to changes in environment. A time coding method is used since several measurements are shared on a single recorder trace

Comparison of various methods to delineate blood vessels in retinal images

The blood vessels in the human retina are easily visualisable via digital fundus photography and provide an excellent window to the health of a patient affected by diseases of blood circulation such as diabetes. Diabetic retinopathy is identifiable through lesions of the vessels such as narrowing of the arteriole walls, beading of venules into sausage like structures and new vessel growth as an attempt to reperfuse ischaemic regions. Automated quantification of these lesions would be beneficial to diabetes research and to clinical practice, particularly for eye-screening programmes for the detection of eye-disease amongst diabetic persons

Retinal Vessel Segmentation Using the 2-D Morlet Wavelet and Supervised Classification

We present a method for automated segmentation of the vasculature in retinal images. The method produces segmentations by classifying each image pixel as vessel or non-vessel, based on the pixel's feature vector. Feature vectors are composed of the pixel's intensity and continuous two-dimensional Morlet wavelet transform responses taken at multiple scales. The Morlet wavelet is capable of tuning to specific frequencies, thus allowing noise filtering and vessel enhancement in a single step. We use a Bayesian classifier with class-conditional probability density functions (likelihoods) described as Gaussian mixtures, yielding a fast classification, while being able to model complex decision surfaces and compare its performance with the linear minimum squared error classifier. The probability distributions are estimated based on a training set of labeled pixels obtained from manual segmentations. The method's performance is evaluated on publicly available DRIVE and STARE databases of manually labeled non-mydriatic images. On the DRIVE database, it achieves an area under the receiver operating characteristic (ROC) curve of 0.9598, being slightly superior than that presented by the method of Staal et al.Comment: 9 pages, 7 figures and 1 table. Accepted for publication in IEEE Trans Med Imag; added copyright notic

Molecular basis of chemosensitivity of platinum pre-treated ovarian cancer to chemotherapy

Ovarian cancer shows considerable heterogeneity in its sensitivity to chemotherapy both clinically and in vitro. This study tested the hypothesis that the molecular basis of this difference lies within the known resistance mechanisms inherent to these patients' tumours

Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma

BACKGROUND: We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared with that of a similar assay used in a different country in terms of evaluability and clinical endpoints. METHODS: From November 1998 to November 2001, 46 patients with pre-treated, advanced ovarian cancer were given a total of 56 courses of chemotherapy based on in-vitro ATP-TCA responses obtained from fresh tumor samples or ascites. Forty-four patients were evaluable for results. Of these, 18 patients had clinically platinum resistant disease (relapse < 6 months after first course of chemotherapy). There was evidence of cisplatin resistance in 31 patients from their first ATP-TCA. Response to treatment was assessed by radiology, clinical assessment and tumor marker level (CA 125). RESULTS: The overall response rate was 59% (33/56) per course of chemotherapy, including 12 complete responses, 21 partial responses, 6 with stable disease, and 15 with progressive disease. Two patients were not evaluable for response having received just one cycle of chemotherapy: if these were excluded the response rate is 61%. Fifteen patients are still alive. Median progression free survival (PFS) was 6.6 months per course of chemotherapy; median overall survival (OAS) for each patient following the start of TCA-directed therapy was 10.4 months (95% confidence interval 7.9-12.8 months). CONCLUSION: The results show similar response rates to previous studies using ATP-TCA directed therapy in recurrent ovarian cancer. The assay shows high evaluability and this study adds weight to the reproducibility of results from different centre