The adjusted International Prognostic Index and beta-2-microglobulin predict the outcome after autologous stem cell transplantation in relapsing/refractory peripheral T-cell lymphoma

BACKGROUND AND OBJECTIVES: Preliminary data on the use of autologous stem cell transplantation (ASCT) as a salvage therapy for peripheral T-cell lymphoma (PTCL) indicate that the results are similar to those obtained in aggressive B-cell lymphomas. The aim of our study was to analyze outcomes of a large series of patients with PTCL with a prolonged follow-up who received ASCT as salvage therapy. DESIGN AND METHODS: Between 1990 and 2004, 123 patients in this situation were registered in the GELTAMO database. The median age at transplantation was 43.5 years; in 91% of patients the disease was chemosensitive. RESULTS: Seventy-three percent of the patients achieved complete remission, 11% partial remission and the procedure failed in 16%. At a median follow-up of 61 months, the 5-year overall and progression-free survival rates were 45% and 34%, respectively. The presence of more than one factor of the adjusted International Prognostic Index (a-IPI) and a high beta2-microglobulin at transplantation were identified as adverse prognostic factors for both overall and progression-free survival and allowed the population to be stratified into three distinct risk groups. INTERPRETATION AND CONCLUSIONS: Our data show that approximately one third of patients with PTCL in the salvage setting may enjoy prolonged survival following ASCT, provided they are transplanted in a chemosensitive disease state. The a-IPI and beta2-microglobulin level predict the outcome after ASCT in relapsing/refractory PTCL

Prolonged survival of patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation: the GELTAMO experience

Abstract OBJECTIVES: Angioimmunoblastic T-cell lymphoma (AIL) is a rare lymphoma with a poor prognosis and no standard treatment. Here, we report our experiences with 19 patients treated with high-dose chemotherapy and autologous stem cell transplantation (HDC/ASCT) within the GELTAMO co-operative group between 1992 and 2004. METHODS: The median age at transplantation was 46 yr. Fifteen patients underwent the procedure as front-line therapy and four patients as salvage therapy. Most patients received peripheral stem cells (90%) coupled with BEAM or BEAC as conditioning regimen (79%). RESULTS: A 79% of patients achieved complete response, 5% partial response and 16% failed the procedure. After a median follow-up of 25 months, eight patients died (seven of progressive disease and secondary neoplasia), while actuarial overall survival and progression-free survival at 3 yr was 60% and 55%. Prognostic factors associated with a poor outcome included bone marrow involvement, transplantation in refractory disease state, attributing more than one factor of the age-adjusted-International Prognostic Index, Pretransplant peripheral T-cell lymphoma (PTCL) Score or Prognostic Index for PTCL. CONCLUSIONS: More than half of the patients with AIL that display unfavourable prognostic factors at diagnosis or relapse would be expected to be alive and disease-free after 3 yr when treated with HDC/ASCT. Patients who are transplanted in a refractory disease state do not benefit from this procedure

Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice

Chromosomal translocations involving the MALT1 gene are hallmarks of mucosa-associated lymphoid tissue (MALT) lymphoma. To date, targeting these translocations to mouse B cells has failed to reproduce human disease. Here, we induced MALT1 expression in mouse Sca1(+)Lin(-) hematopoietic stem/progenitor cells, which showed NF-κB activation and early lymphoid priming, being selectively skewed toward B-cell differentiation. These cells accumulated in extranodal tissues and gave rise to clonal tumors recapitulating the principal clinical, biological, and molecular genetic features of MALT lymphoma. Deletion of p53 gene accelerated tumor onset and induced transformation of MALT lymphoma to activated B-cell diffuse large-cell lymphoma (ABC-DLBCL). Treatment of MALT1-induced lymphomas with a specific inhibitor of MALT1 proteolytic activity decreased cell viability, indicating that endogenous Malt1 signaling was required for tumor cell survival. Our study shows that human-like lymphomas can be modeled in mice by targeting MALT1 expression to hematopoietic stem/progenitor cells, demonstrating the oncogenic role of MALT1 in lymphomagenesis. Furthermore, this work establishes a molecular link between MALT lymphoma and ABC-DLBCL, and provides mouse models to test MALT1 inhibitors. Finally, our results suggest that hematopoietic stem/progenitor cells may be involved in the pathogenesis of human mature B-cell lymphomas

Innovación educativa

Se analiza el uso de la prensa en el aula desde parámetros constructivistas, promoviendo una utilización amplia y eficaz de este medio de comunicación. Ofrece una visión general del mismo, en el ámbito de las nuevas reformas educativas del año 1992. A continuación, estudia el marco institucional, al amparo del convenio MEC-AEDE de otoño de 1985 y la perspectiva internacional sobre el uso educativo de la prensa en el aula. Por último, aborda los objetivos generales propuestos, incluyendo actividades agrupadas bajo temáticas comunes como, conocer qué es un periódico, el periódico como instrumento de aprendizaje o el periódico en trabajos monográficos.GaliciaBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]

The results of consolidation with autologous stem-cell transplantation in patients with peripheral T-cell lymphoma (PTCL) in first complete remission: the Spanish Lymphoma and Autologous Transplantation Group experience

Abstract BACKGROUND: Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of aggressive lymphomas associated with poor prognosis with standard chemotherapy. Consolidation with autologous stem-cell transplantation (ASCT) may improve survival. We present 74 patients transplanted in first complete response (CR) from the Spanish Lymphoma and Autologous Transplantation Group cooperative group. PATIENTS AND METHODS: Median age was 46 years. Eighty-eight percent presented advanced (III-IV) Ann Arbor stage; 53% had B symptoms; 52% had high lactate dehydrogenase; 65% had two or three risk factors of the adjusted-International Prognostic Index; 58% presented a high Tumor score and in 14% more than two adverse factors of the Prognostic Index for peripheral T-cell lymphoma (PIT) were observed. RESULTS: With a median follow-up of 67 months from diagnosis, the 5-year overall survival (OS) was 68% and progression-free survival (PFS) reached 63%. The multivariate analysis showed that the only factor associated with a shorter OS and PFS was the presence of more than two risk factors from the PIT risk system. CONCLUSIONS: In a retrospective study with a prolonged follow-up, consolidation with ASCT in CR patients who had presented unfavorable prognostic factors at diagnosis substantially increased the OS and PFS when compared with conventional chemotherapy. The PIT risk system identified 14% of patients without benefit from ASCT consolidation. Thus, other innovative therapies are still necessary in certain cases

The results of consolidation with autologous stem-cell transplantation in patients with peripheral T-cell lymphoma (PTCL) in first complete remission: the Spanish Lymphoma and Autologous Transplantation Group experience

Abstract BACKGROUND: Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of aggressive lymphomas associated with poor prognosis with standard chemotherapy. Consolidation with autologous stem-cell transplantation (ASCT) may improve survival. We present 74 patients transplanted in first complete response (CR) from the Spanish Lymphoma and Autologous Transplantation Group cooperative group. PATIENTS AND METHODS: Median age was 46 years. Eighty-eight percent presented advanced (III-IV) Ann Arbor stage; 53% had B symptoms; 52% had high lactate dehydrogenase; 65% had two or three risk factors of the adjusted-International Prognostic Index; 58% presented a high Tumor score and in 14% more than two adverse factors of the Prognostic Index for peripheral T-cell lymphoma (PIT) were observed. RESULTS: With a median follow-up of 67 months from diagnosis, the 5-year overall survival (OS) was 68% and progression-free survival (PFS) reached 63%. The multivariate analysis showed that the only factor associated with a shorter OS and PFS was the presence of more than two risk factors from the PIT risk system. CONCLUSIONS: In a retrospective study with a prolonged follow-up, consolidation with ASCT in CR patients who had presented unfavorable prognostic factors at diagnosis substantially increased the OS and PFS when compared with conventional chemotherapy. The PIT risk system identified 14% of patients without benefit from ASCT consolidation. Thus, other innovative therapies are still necessary in certain cases

Frontline autologous stem cell transplantation in high-risk peripheral T-cell lymphoma: a prospective study from The Gel-Tamo Study Group

OBJECTIVE: Retrospective data shows that peripheral T-cell lymphoma (PTCL) patients sensitive to conventional chemotherapy for aggressive lymphomas may respond better if this treatment is consolidated with frontline autologous stem cell transplantation (ASCT). Here, we present data from a prospective phase II trial of high-dose chemotherapy and ASCT as a frontline consolidation therapy for aggressive nodal PTCL. METHODS: This study involved 26 gallium-scan-positive patients with high-risk nodal PTCL [excluding anaplastic lymphoma kinase (ALK) positive]. Patients received three courses of MegaCHOP before they were evaluated, and those that were gallium-scan-negative at this stage then received another course of MegaCHOP and ASCT. Patients who remained gallium-scan-positive received two courses of an IFE regimen (ifosfamide 10 g/m(2), etoposide 150 mg/m(2)/12 h on days 1-3) and if they at least achieved PR, they then received the transplant. RESULTS: Complete response (CR) was achieved by 12 patients (46%) after three courses of MegaCHOP and 12 patients received IFE as a salvage therapy. After the ASCT (n = 19), 89% of patients achieved CR. In contrast, six patients (23%) did not receive the transplant because of the progression of the disease (n = 5) or lethal toxicity (n = 1). One patient in first-line CR refused ASCT. After a median follow-up of 35 months, the overall survival (OS) and progression-free survival (PFS) at 3 yr was 73% and 53%, respectively. Moreover, the OS, PFS and disease-free survival (DFS) were 84%, 56% and 63%, respectively 2 yr after transplant in patients who received ASCT consolidation (n = 19). CONCLUSIONS: Early salvage therapy for patients with high-risk aggressive nodal PTCL that do not achieve CR after three courses of chemotherapy and ASCT frontline consolidation for chemosensitive patients may improve treatment outcome

Comparable Survival Between HIV+ and HIV- non-Hodgkin and Hodgkin Lymphoma Patients Undergoing Autologous Peripheral Blood Stem Cell Transplantation.

Autologous stem cell transplantation (ASCT) has been successfully used in HIV-related lymphoma (HIV-Ly) patients on highly active antiretroviral therapy. We report the first comparative analysis between HIV-Ly and a matched cohort of HIV(-) lymphoma patients. This retrospective European Group for Blood and Marrow Transplantation study included 53 patients (66% non-Hodgkin and 34% Hodgkin lymphoma) within each cohort. Both groups were comparable except for the higher proportion of males, mixed-cellularity Hodgkin lymphoma and patients receiving granulocyte colony-stimulating factor before engraftment and a smaller proportion receiving total body irradiation-based conditioning within the HIV-Ly cohort. Incidence of relapse, overall survival, and progression-free survival were similar in both cohorts. A higher nonrelapse mortality within the first year after ASCT was observed in the HIV-Ly group (8% vs 2%), predominantly because of early bacterial infections, although this was not statistically significant and did not influence survival. Thus, within the highly active antiretroviral therapy era, HIV patients should be considered for ASCT according to the same criteria adopted for HIV(-) lymphoma patients

Anales de Edafología y Agrobiología Tomo 45 Número 1-2

l. Suelos. Química. Comparación de tres métodos diferentes para la medida del pH en los suelos de Gran Canaria. Por J. A. López Lancia, F. Polo Conde, A. Arribi López.-- Suelos AC sobre granitos de Galicia (N.O. de España) con especial referencia al ranker atlántico. V. Mineralogía. Por M. Carballas, M. C. Villar, F. Guitián Ojea y T. Carballas.-- Adsorción de parathion en suelos: influencia del conjunto arcilla-materia orgánica y su posible repercusión en suelos artificiales de invernaderos. Por M. Villafranca Sánchez, E. González Pradas y F. del Rey Bueno.-- Caracterización del fósforo en suelos gallegos: estudio comportamiento de los procedimientos de Chang y Jackson, 1957, y de Hedley Et. Al., 1982. Por Mª C. Trasar Cepeda, F. Gil Sotres y F. Guitián Ojea.-- Estudio de la contaminación por plagicidas en suelos de invernaderos. Por E. González Pradas, M. Villafranca Sánchez, l. Pérez Alvarez, A. Valverde García y R. J. Plaza Capel.-- Génesis de minerales interestratificados de la arcilla a partir de rocas espilíticas de Guernica. Por J. Casas, J. L. M. de Vidales, M. A. Hoyos y J. Guijarro.-- l. Suelos. Génesis, clasificación y cartografía. Formaciones edáficas del sector N.E. de la provincia de Cuenca. (II) inceptisoles. Por J. Batlles Sales, J. Gumuzzio Fernández, J. L. Martín de Vidales.-- Formaciones edáficas del sector N.E. de la provincia de Cuenca. (III) Mollisoles. Por J. Batlles Sales, J. Gumuzzio Fernández, J. L. Martín de Vidales, J. B. Alvarez Martín.-- Mineralogía de andosoles de la zona Cafetalera de Veracruz (México). Por N. García Calderón, T. Aleixandre, A. Pinilla y N. Aguilera.-- Contribución al estudio de suelos de alta montaña (Picos de Europa). l. Morfología, datos analíticos y clasificación. Por M. L. Palomar, G. Villamil, J. Hernando Costa, M. T. de la Cruz Caravaca.- Contribución al estudio de suelos de alta montaña (Picos de Europa). II. Estudio químico y mineralógico. Génesis. Por M. L. Palomar, G. Villamil, J. Hernando Costa, M. T. de la Cruz Caravaca.-- l. Suelos. Fertilidad. Aplicación del análisis factorial a la evaluación de la fertilidad de suelos. Por J. Moreno, M. T. Estañ, V. Martínez López y M. C. Bolarín.—II. Biología Vegetal. Nutrición. Estudio de la composición química de plantas de pimiento a lo largo del ciclo de cultivo. Por P. Zornoza y B. Arozanera.-- Interacción Rhizobium-Micorriza sobre el crecimiento y nutrición de Trifoliumrepens 1, en suelo ácido. Efecto del encalado y de la adición de roca fosfórica. Por D. F. Puccini, R. Azcon, E. J. Bedmar y J. M. Barea.-- Efecto de la aplicación foliar del MO sobre algunos aspectos nutricionales de la planta de patata. Por E. Esteban, J. Robles y F. Gallardo-Lara.-- Efecto de los niveles de Fe y Mn sobre el crecimiento de distintos cultivares de soja (Giycine Max/L/Merr.). Por E. O. Lerdi y M. Gómez.-- Manganeso asimilable en campos del suelo de Cartagena (Murcia). Por J. Moreno, M. T. Estañ, M. G. Guillén y M. C. Bolarín.-- II. Biología Vegetal. Fisiología - Análisis por cromatografia gas-líquido de los derivados silicados de los ácidos fijos del vino. Por F. Henao, J. L. Menas, J. l. Maynar y R. Zamora.-- Características foliares de haploides nicotiana tabacum seleccionados por eficacia fotosintética. Por H. Medrana.-- Susceptibilidad de distintas variedades de guisante, veza y lupino a la infección por glomus mosseae. Por E. J. Bedmar y J. A. Ocampo.-- Influencia del estado de hidratación del talo en los cuerpos de reserva del ficobionte liquénico myrmecia. Por S. Rapsch y C. Ascaso.-- II. Biología Vegetal. Agrobiología - Utilización de los reguladores del crecimiento en los cultivos de cebada. Por l. de la Morena Valenzuela.-- Fitomasa subterránea en pastizales semiáridos de dehesa. Efectos del relieve y evo- lución con la profundidad. Por J. M. Gómez e l. Barrera.-- III. BibliografíaPeer reviewe