1968: It’s Just a Beginning

1968 marks the beginning of a social, political and cultural revolution, with all of its internal contradictions. It engulfs the artistic world on both sides of the Atlantic in a veritable transformation, a cathartic rebirth crystalized through the reconfiguration of traditional canons. This creative impulse refuses any artifice, assimilates contradictions, incorporates experience and imaginary worlds, restructures ideas about space and time, definitely severing the boundary between object and concept, short circuiting reality and the imaginary. Inspired by codes of common origins, minimalism, conceptual art, arte povera and land art nonetheless carry diversity in their approaches and methods; yet they coexist and coalesce, in an intricate weave of exchange and rhythmic syncronicity

Protective role of endothelial nitric oxide synthase

Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to anti-proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the nitric oxide synthases, endothelial NOS (eNOS), neural NOS (nNOS), and inducible NOS (iNOS). Constitutively expressed eNOS produces low concentrations of NO, which is necessary for a good endothelial function and integrity. Endothelial derived NO is often seen as a protective agent in a variety of diseases. This review will focus on the potential protective role of eNOS. We will discuss recent data derived from studies in eNOS knockout mice and other experimental models. Furthermore, the role of eNOS in human diseases is described and possible therapeutic intervention strategies will be discussed

1968

1968 was \uabthe year that would subvert the world\ubb when revolutions, the undermining of the established order and new prospects marked every aspect of the social, cultural and artistic life in the western world. In architecture, the irruption of such novelties generated movements of reaction and opposition: updates to the critique of Modernism and attempts to refounding the discipline, new fields of theoretical exploration, visionary scenarios of technological utopias, new processes in the architectural practice. At the same time, the conservative trends that will produce a \u201creturn to order\u201d in some fundamental experiences of \u201970s to \u201880s are taking shape. After fifty years from that pivotal date, HPA publishes a monographic issue that collects a set of original contributions on some still unexplored episodes from such an intense and meaningful moment in history

Mimmo Rotella e il Surrealismo: i rimandi all’iconografia surrealista negli oggetti, nei frottages e negli éffaçages

Il volume è pubblicato in occasione del centenario della nascita di Mimmo Rotella, in concomitanza della più ampia mostra mai realizzata sull'artista. Ricco di contributi critici e di un vasto apparato iconografico, il volume ripercorre tutte le tappe della carriera dell'artista, nato a Catanzaro nel 1918: dalle prime opere astratte, alle esperienze informali degli anni '50, dalla relazione con il Nouveau Réalisme di Pierre Restany, alle tangenze con la Pop Art, al rapporto con l'America. Ampio approfondimento è dedicato alla sua ricerca più nota, quella intorno ai décollages e ai retro d'affiches, ma viene anche indagato il rapporto con città come New York, Roma, Parigi e Milano, con la critica d'arte e con gli artisti contemporanei. Completano il volume apparati biobibliografici. testi di: Clare Bell, Tobia Bezzola, Paola Bonani, Ester Coen, Vincenzo De Bellis, Veronica Locatelli, Lola Lorant, Elizabeth Mangini, Gianfranco Maraniello, Massimo Mininni, Luca Pietro Nicoletti, Massimo Romeri, Paul-Louis Roubert, Francesca Pola, Marta Sironi, Antonella Soldaini, Chiara Spangaro, Francesco Tedeschi, Giulia Tulino, Riccardo Ventur

Diagnostic and therapeutic appropriateness in bone and joint infections: results of a national survey

27noThe impact of infectious diseases (ID) specialist consultation in the management of many types of bacterial infections has been fully demonstrated but not for bone and joint infections (BJIs). Nineteen ID Italian centres collected of data from June 2009 to May 2012. Italian guidelines (2009) were used to determine the appropriateness of the diagnostic and therapeutic process of BJIs before and after consulting an ID specialist. Data on 311 patients were collected: 111 cases of prosthetic joint infection, 99 osteomyelitis, 64 spondylodiscitis and 37 fixation device infection. A significant increase of microbiological investigations, imaging techniques and blood inflammation markers were noted after consulting the ID specialist. Moreover, inappropriateness of treatment duration, dosage, and number of administrations significantly decreased after consultation. Infectious disease specialist intervention in the management of BJIs significantly increases the appropriateness both in performing instrumental and laboratory analysis, but especially in determining the correct therapy.nonenoneEsposito, Silvano; Russo, Enrico; De Simone, Giuseppe; Gioia, Renato; Petta, Ester; Leone, Sebastiano; Noviello, Silvana; Artioli, Stefania; Ascione, Tiziana; Bartoloni, Alessandro; Bassetti, Matteo; Bertelli, Davide; Boccia, Giovanni; Borrè, Silvio; Brugnaro, Pierluigi; Caramello, Pietro; Coen, Massimo; Crisalli, Maria Paola; De Caro, Francesco; Dodi, Ferdinando; Fantoni, Massimo; Foti, Giuseppe; Giacometti, Andrea; Leoncini, Francesco; Libanore, Marco; Migliore, Simona; Venditti, MarioEsposito, Silvano; Russo, Enrico; De Simone, Giuseppe; Gioia, Renato; Petta, Ester; Leone, Sebastiano; Noviello, Silvana; Artioli, Stefania; Ascione, Tiziana; Bartoloni, Alessandro; Bassetti, Matteo; Bertelli, Davide; Boccia, Giovanni; Borrè, Silvio; Brugnaro, Pierluigi; Caramello, Pietro; Coen, Massimo; Crisalli, Maria Paola; De Caro, Francesco; Dodi, Ferdinando; Fantoni, Massimo; Foti, Giuseppe; Giacometti, Andrea; Leoncini, Francesco; Libanore, Marco; Migliore, Simona; Venditti, Mari

Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood:a large-scale epigenome-wide association analysis in 5841 individuals

BACKGROUND: Folate and vitamin B-12 are essential micronutrients involved in the donation of methyl groups in cellular metabolism. However, associations between intake of these nutrients and genome-wide DNA methylation levels have not been studied comprehensively in humans. OBJECTIVE: The aim of this study was to assess whether folate and/or vitamin B-12 intake are asssociated with genome-wide changes in DNA methylation in leukocytes. METHODS: A large-scale epigenome-wide association study of folate and vitamin B-12 intake was performed on DNA from 5841 participants from 10 cohorts using Illumina 450k arrays. Folate and vitamin B-12 intakes were calculated from food-frequency questionnaires (FFQs). Continuous and categorical (low compared with high intake) linear regression mixed models were applied per cohort, controlling for confounders. A meta-analysis was performed to identify significant differentially methylated positions (DMPs) and regions (DMRs), and a pathway analysis was performed on the DMR annotated genes. RESULTS: The categorical model resulted in 6 DMPs, which are all negatively associated with folate intake, annotated to FAM64A, WRAP73, FRMD8, CUX1, and LCN8 genes, which have a role in cellular processes including centrosome localization, cell proliferation, and tumorigenesis. Regional analysis showed 74 folate-associated DMRs, of which 73 were negatively associated with folate intake. The most significant folate-associated DMR was a 400-base pair (bp) spanning region annotated to the LGALS3BP gene. In the categorical model, vitamin B-12 intake was associated with 29 DMRs annotated to 48 genes, of which the most significant was a 1100-bp spanning region annotated to the calcium-binding tyrosine phosphorylation-regulated gene (CABYR). Vitamin B-12 intake was not associated with DMPs. CONCLUSIONS: We identified novel epigenetic loci that are associated with folate and vitamin B-12 intake. Interestingly, we found a negative association between folate and DNA methylation. Replication of these methylation loci is necessary in future studies