Measuring Perceived Effects of Drinking an Extract of Basidiomycetes Agaricus Blazei Murill: A Survey of Japanese Consumers with Cancer

BACKGROUND. To survey cancer patients who consume an extract of the Basidiomycetes Agaricus blazei Murill mushroom (Sen-Sei-Ro) to measure their self-assessment of its effects and to develop an instrument for use in future randomized trials. METHODS. We designed, translated and mailed a survey to 2,346 Japanese consumers of Sen-Sei-Ro self-designated as cancer patients. The survey assessed consumer demographics, cancer history, Sen-Sei-Ro consumption, and its perceived effects. We performed exploratory psychometric analyses to identify distinct, multi-item scales that could summarize perceptions of effects. RESULTS. We received completed questionnaires from 782 (33%) of the sampled Sen-Sei-Ro consumers with a cancer history. Respondents represented a broad range of cancer patients familiar with Sen-Sei-Ro. Nearly all had begun consumption after their cancer diagnosis. These consumers expressed consistently positive views, though not extremely so, with more benefit reported for more abstract benefits such as emotional and physical well-being than relief of specific symptoms. We identified two conceptually and empirically distinct and internally consistent summary scales measuring Sen-Sei-Ro consumers' perceptions of its effects, Relief of Symptoms and Functional Well-being (Cronbach's alpha: Relief of Symptoms, α = .74; Functional Well-Being, α = .91). CONCLUSION. Respondents to our survey of Sen-Sei-Ro consumers with cancer reported favorable perceived effects from its use. Our instrument, when further validated, may be a useful outcome in trials assessing this and other complementary and alternative medicine (CAM) substances in cancer patients.Kyowa-S.S.I., Tokyo, Japa

Evaluating EPflex MRline Guidewire for Endovascular Interventions Guided by MRI at 3T vs. X-ray Fluoroscopy

This project sought to evaluate the efficacy of using the EPflex MRline guidewire for endovascular treatment guided by real-time Magnetic Resonance Imaging (MRI). MRI theoretically has numerous advantages over x-ray, the current clinical standard imaging modality for endovascular procedures. The most profound advantage of MRI is the ability to acquire physiological functional information, via perfusion and diffusion measures, for better intervention planning before and during the procedure. The EPflex guidewire was selectedbecause of its ability to perform in an MRI and x-ray fluoroscopy environment, allowing for relevant and useful comparisons of the guiding imaging modality. An abdominal aorta phantom was used to assess the ability of experienced and inexperienced operators to successfullynavigate the wire under each imaging modality. It was found that x-ray guidance provided statistically faster and more successful navigation attempts than MRI guidance; however, more clinical tests need to be performed in order to assess the clinical significance of these results.This study represents an important step in the direction of developing safer and more effective imaging systems for guiding endovascular procedures

Regulatory Markets: The Future of AI Governance

Appropriately regulating artificial intelligence is an increasingly urgent policy challenge. Legislatures and regulators lack the specialized knowledge required to best translate public demands into legal requirements. Overreliance on industry self-regulation fails to hold producers and users of AI systems accountable to democratic demands. Regulatory markets, in which governments require the targets of regulation to purchase regulatory services from a private regulator, are proposed. This approach to AI regulation could overcome the limitations of both command-and-control regulation and self-regulation. Regulatory market could enable governments to establish policy priorities for the regulation of AI, whilst relying on market forces and industry R&D efforts to pioneer the methods of regulation that best achieve policymakers' stated objectives

The story of your city (Volume 1)

By the end of this century, 9 out of 10 Europeans will live in an urban area. But what kind of city will they call home? You'll find all the answers in CITY, TRANSFORMED, the new essay series from the European Investment Bank. This panoramic first essay in the series lays out a great sweeping history of European cities over the last fifty years—and showcases new directions being taken by some of our most innovative cities. Urban experts Greg Clark, Tim Moonen, and Jake Nunley based at University College London take a definitive look at how Europe's cities transformed from post-industrial decline to thriving metropolises that are as prosperous and liveable as anywhere on Earth

Faith is my Fortune: A Life Story of George Pepperdine

This memoir, dictated to the authors by George Pepperdine, is subtitled “actual experiences, business success and reverses, stewardship and philanthropy, which have proved that strong religious faith is a greater fortune, more to be desired than riches, or any other assets.” This is the story of George Pepperdine (1886-1962), founder of Western Auto Supply and, later, Pepperdine University in Southern California. Pepperdine was a noted businessman, philanthropist, and a lifelong member of Churches of Christ.https://digitalcommons.pepperdine.edu/heritage_center/1002/thumbnail.jp