360 research outputs found
PSPL Survey: The Evaluation Method for Quality of Public Space and Public Life:The Study on Jan Gehl's Theory and Method for Public Space Design (Part 3)
Nobel-Prize-winning papers are significantly more highly-cited but not more disruptive than non-prize-winning counterparts
Using citation data of 557 Nobel prize winning papers and the same number of their non-prize winning counterparts in the same journal issues, we examined if the prize-winning papers have higher academic disruption than their counterparts. The results show that overall, the former group is significantly more highly-cited but not more disruptive than the latter. Moreover, the results are not consistent with existing knowledge that the numbers of authors and references negatively correlate with the disruption of papers
Pedestrian Space Design & Walking Behavior Option ââThe Study on Jan Gehlâs Theory for public space Design (Part 1)
Design of Staying Space & Emergence of Public Life:The Study on Jan Gehl's Theory for Public Space Design (Part 2)
Melatonin protects against ovarian damage by inhibiting autophagy in granulosa cells in rats
Objectives: This study sought to further verify the protective mechanism of Melatonin (MT) against ovarian damage through animal model experiments and to lay a theoretical and experimental foundation for exploring new approaches for ovarian damage treatment.
Method: The wet weight and ovarian index of rat ovaries were weighted, and the morphology of ovarian tissues and the number of follicles in the pathological sections of collected ovarian tissues were recorded. And the serum sex hormone levels, the key proteins of the autophagy pathway (PI3K, AKT, mTOR, LC3II, LC3I, and Agt5) in rat ovarian tissues, as well as the viability and mortality of ovarian granulosa cells in each group were measured by ELISA, western blotting, CCK8 kit and LDH kit, respectively.
Results: The results showed that MT increased ovarian weight and improved the ovarian index in ovarian damage rats. Also, MT could improve autophagy-induced ovarian tissue injury, increase the number of primordial follicles, primary follicles, and sinus follicles, and decrease the number of atretic follicles. Furthermore, MT upregulated serum AMH, INH-B, and E2 levels downregulated serum FSH and LH levels in ovarian damage rats and activated the PI3K/AKT/mTOR signaling pathway. Besides, MT inhibited autophagic apoptosis of ovarian granulosa cells and repressed the expression of key proteins in the autophagic pathway and reduced the expression levels of Agt5 and LC3II/I.
Conclusions: MT inhibits granulosa cell autophagy by activating the PI3K/Akt/mTOR signaling pathway, thereby exerting a protective effect against ovarian damage
Flipbot: Learning Continuous Paper Flipping via Coarse-to-Fine Exteroceptive-Proprioceptive Exploration
This paper tackles the task of singulating and grasping paper-like deformable
objects. We refer to such tasks as paper-flipping. In contrast to manipulating
deformable objects that lack compression strength (such as shirts and ropes),
minor variations in the physical properties of the paper-like deformable
objects significantly impact the results, making manipulation highly
challenging. Here, we present Flipbot, a novel solution for flipping paper-like
deformable objects. Flipbot allows the robot to capture object physical
properties by integrating exteroceptive and proprioceptive perceptions that are
indispensable for manipulating deformable objects. Furthermore, by
incorporating a proposed coarse-to-fine exploration process, the system is
capable of learning the optimal control parameters for effective paper-flipping
through proprioceptive and exteroceptive inputs. We deploy our method on a
real-world robot with a soft gripper and learn in a self-supervised manner. The
resulting policy demonstrates the effectiveness of Flipbot on paper-flipping
tasks with various settings beyond the reach of prior studies, including but
not limited to flipping pages throughout a book and emptying paper sheets in a
box.Comment: Accepted to International Conference on Robotics and Automation
(ICRA) 202
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