pDEMtools: conveniently search, download, and processArcticDEM and REMA products

pdemtools is a Python package designed for accessing, processing, and handling high-resolution Digital Elevation Models (DEMs) of the polar regions from the ArcticDEM and Reference Elevation Model of Antarctica (REMA) projects. Tools are provided to search, filter, and download ArcticDEM and REMA data, as well as to fulfill common preprocessing requirements such as geoid correction, coregistration, and calculating terrain attributes. The aim is to allow users to quickly move beyond basic DEM data management into their own analyses

Borehole-Based Characterization of Deep Mixed-Mode Crevasses at a Greenlandic Outlet Glacier

Funder: Aberystwyth University Capital Equipment FundAbstract: Optical televiewer borehole logging within a crevassed region of fast‐moving Store Glacier, Greenland, revealed the presence of 35 high‐angle planes that cut across the background primary stratification. These planes were composed of a bubble‐free layer of refrozen ice, most of which hosted thin laminae of bubble‐rich “last frozen” ice, consistent with the planes being the traces of former open crevasses. Several such last‐frozen laminae were observed in four traces, suggesting multiple episodes of crevasse reactivation. The frequency of crevasse traces generally decreased with depth, with the deepest detectable trace being 265 m below the surface. This is consistent with the extent of the warmer‐than‐modeled englacial ice layer in the area, which extends from the surface to a depth of ∼400 m. Crevasse trace orientation was strongly clustered around a dip of 63° and a strike that was offset by 71° from orthogonal to the local direction of principal extending strain. The traces’ antecedent crevasses were therefore interpreted to have originated upglacier, probably ∼8 km distant involving mixed‐mode (I and III) formation. We conclude that deep crevassing is pervasive across Store Glacier, and therefore also at all dynamically similar outlet glaciers. Once healed, their traces represent planes of weakness subject to reactivation during subsequent advection through the glacier. Given their depth, it is highly likely that such traces—particularly those formed downglacier—survive surface ablation to reach the glacier terminus, where they may represent foci for fracture and iceberg calving

Evaluating UAV‐based multispectral imagery for mapping an intertidal seagrass environment

Worldwide seagrass habitats are under severe anthropogenic threat. In the United Kingdom (UK), the health of habitats of the widely distributed Zostera species is particularly threatened by eutrophication that can lead to detrimental macroalgae overgrowth. To manage and conserve seagrass habitats, effective monitoring tools are required. We use an off‐the‐shelf consumer‐grade multispectral (RGB, red edge, and near‐infrared) camera mounted on an unoccupied aerial vehicle (UAV) to map an intertidal multispecies seagrass environment in Lindisfarne National Nature Reserve, Northumberland, UK. Field surveys were undertaken of three seagrass areas, including those dominated by Zostera noltii , Zostera marina and macroalgae. Using the Maximum Likelihood Classifier (MLC), results indicated an overall accuracy (OA) between 84% and 91% across classified habitat maps. As expected, the red edge and near‐infrared bands offered an advantage beyond RGB imagery to discriminate between the vegetation types for accurate habitat mapping. Our research provides a foundation for accurately mapping a complex intertidal seagrass environment through the utilisation of an off‐the‐shelf multispectral UAV. The study may aid the implementation and development of effective monitoring programmes for the management of Zostera spp. decline and macroalgae proliferation to prevent seagrass degradation and conserve these valuable yet fragile ecosystems

Thermodynamics of a fast-moving Greenlandic outlet glacier revealed by fiber-optic distributed temperature sensing

Funding: This research was funded by the European Research Council as part of the RESPONDER project under the European Union’s Horizon 2020 research and innovation program (grant 683043). R.L. and T.R.C. were supported by Natural Environment Research Council Doctoral Training Partnership studentships (grant NE/ L002507/1). B.H. was supported by a HEFCW/Aberystwyth University Capital Equipment Grant.Measurements of ice temperature provide crucial constraints on ice viscosity and the thermodynamic processes occurring within a glacier. However, such measurements are presently limited by a small number of relatively coarse-spatial-resolution borehole records, especially for ice sheets. Here, we advance our understanding of glacier thermodynamics with an exceptionally high-vertical-resolution (~0.65 m), distributed-fiber-optic temperature-sensing profile from a 1043-m borehole drilled to the base of Sermeq Kujalleq (Store Glacier), Greenland. We report substantial but isolated strain heating within interglacial-phase ice at 208 to 242 m depth together with strongly heterogeneous ice deformation in glacial-phase ice below 889 m. We also observe a high-strain interface between glacial- and interglacial-phase ice and a 73-m-thick temperate basal layer, interpreted as locally formed and important for the glacier's fast motion. These findings demonstrate notable spatial heterogeneity, both vertically and at the catchment scale, in the conditions facilitating the fast motion of marine-terminating glaciers in Greenland.Publisher PDFPeer reviewe

Intermittent PI3Ko inhibition sustains anti-tumor immunity and curbs irAEs

YesPhosphoinositide 3-kinase δ (PI3Kδ) has a key role in lymphocytes, and inhibitors that target this PI3K have been approved for treatment of B cell malignancies1–3. Although studies in mouse models of solid tumours have demonstrated that PI3Kδ inhibitors (PI3Kδi) can induce anti-tumour immunity4,5, its effect on solid tumours in humans remains unclear. Here we assessed the effects of the PI3Kδi AMG319 in human patients with head and neck cancer in a neoadjuvant, double-blind, placebo-controlled randomized phase II trial (EudraCT no. 2014-004388-20). PI3Kδ inhibition decreased the number of tumour-infiltrating regulatory T (Treg) cells and enhanced the cytotoxic potential of tumour-infiltrating T cells. At the tested doses of AMG319, immune-related adverse events (irAEs) required treatment to be discontinued in 12 out of 21 of patients treated with AMG319, suggestive of systemic effects on Treg cells. Accordingly, in mouse models, PI3Kδi decreased the number of Treg cells systemically and caused colitis. Single-cell RNA-sequencing analysis revealed a PI3Kδi-driven loss of tissue-resident colonic ST2 Treg cells, accompanied by expansion of pathogenic T helper 17 (TH17) and type 17 CD8+ T (TC17) cells, which probably contributed to toxicity; this points towards a specific mode of action for the emergence of irAEs. A modified treatment regimen with intermittent dosing of PI3Kδi in mouse models led to a significant decrease in tumour growth without inducing pathogenic T cells in colonic tissue, indicating that alternative dosing regimens might limit toxicity

SRPK3 Is essential for cognitive and ocular development in humans and zebrafish, explaining X-linked intellectual disability

Objective Intellectual disability is often the outcome of neurodevelopmental disorders and is characterized by significant impairments in intellectual and adaptive functioning. X-linked intellectual disability (XLID) is a subset of these disorders caused by genetic defects on the X chromosome, affecting about 2 out of 1,000 males. In syndromic form, it leads to a broad range of cognitive, behavioral, ocular, and physical disabilities. Methods Employing exome or genome sequencing, here we identified 4 missense variants (c.475C > G; p.H159D, c.1373C > A; p.T458N, and c.1585G > A; p.E529K, c.953C > T; p.S318L) and a putative truncating variant (c.1413_1414del; p.Y471*) in the SRPK3 gene in 9 XLID patients from 5 unrelated families. To validate SRPK3 as a novel XLID gene, we established a knockout (KO) model of the SRPK3 orthologue in zebrafish. Results The 8 patients ascertained postnatally shared common clinical features including intellectual disability, agenesis of the corpus callosum, abnormal eye movement, and ataxia. A ninth case, ascertained prenatally, had a complex structural brain phenotype. Together, these data indicate a pathological role of SRPK3 in neurodevelopmental disorders. In post-fertilization day 5 larvae (free swimming stage), KO zebrafish exhibited severe deficits in eye movement and swim bladder inflation, mimicking uncontrolled ocular movement and physical clumsiness observed in human patients. In adult KO zebrafish, cerebellar agenesis and behavioral abnormalities were observed, recapitulating human phenotypes of cerebellar atrophy and intellectual disability. Interpretation Overall, these results suggest a crucial role of SRPK3 in the pathogenesis of syndromic X-linked intellectual disability and provide new insights into brain development, cognitive and ocular dysfunction in both humans and zebrafish. ANN NEUROL 202

Research data supporting "Glacier surging in the West Kunlun Shan"

Stacked Landsat 2 MSS (band 4, 60 m resolution), Landsat 5 TM (band 1, 30 m resolution), Landsat 7 ETM+ (band 8, 15 m resolution), and Landsat 8 OLI (band 8, 15 m resolution) imagery from 1972--2016, visualising the surges of 8 glaciers in the West Kunlun Shan, Xinjiang, China. Frames are annotated in the form YYYY_DDD, where YYYY is the year and DDD is the Julian day for that year. Information about location and scale of imagery can be found in the appendix of the related Master's thesis. Landsat data is provided by the USGS at earthexplorer.usgs.govThis work was supported by the Isaac Newton Trust (Newton College Master's Studentship) and Downing College (John Whitworth Master's Studentship)

Glacier surges in the north-west West Kunlun Shan inferred from 1972 to 2017 Landsat imagery

ABSTRACTThe West Kunlun Shan lie close to, or are perhaps part of, two significant glaciological phenomena – the High Mountain Asia surge ‘supercluster’ and the Karakoram Anomaly. However, glaciological studies, and particularly surge studies, in the range are limited. Here, we extend the database of known surges in the region using Landsat imagery and cross-correlation feature tracking. We examine 88 glaciers larger than 1 km2in the Hotan Prefecture of Xinjiang, China, and find evidence of nine surges occurring between 1972 and 2017. Glaciers display low active phase velocities (~0.2–1.5 km a−1) that show seasonal acceleration in the summer, active phase periods as short as 2 years, and build-up and deceleration phases of months--years. Although these observations display characteristics indicative of both the classic hydrological and thermal switch mechanisms, the surging observed displays a close resemblance to that in the adjacent Karakoram ranges. Furthermore, the majority of the surges occur clustered at the end of a decadal-scale warming period, corroborating previously proposed causal links between climate and surging in the Karakoram. We suggest that the two regions should be considered part of one larger system when considering surge dynamics in High Mountain Asia.Newton Trust: Newton College Master's Studentship Downing College: John Whitworth Master's Studentshi