Lessons Learned from the 9/11 and WMD Commissions: IRTPA, CIA and the Intelligence Community

At the request of the CIA's Center for the Study of Intelligence, a team from the Bush School conducted an inquiry to determine how the CIA responded to the investigations of the 9/11 and WMD Commissions. The goal of the project, which involved interviews with several commissioners and numerous key staff members, was to identify what actions the D/CIA must take when confronted with future commissions to ensure that the most accurate picture of the Agency is presented, while preventing the formation of inaccurate negative impressions created by the manner in which Agency personnel interact with investigators. At the conclusion of the Capstone, the students prepared a report and orally briefed Agency supervisors on their findings and recommendations.Center for the Study of Intelligence, Central Intelligence Agenc

Size-related habitat shifts facilitated by positive preference induction in a marine kelp crab

Individual variation in habitat use has important ecological and evolutionary consequences. Here, we combine developmental and functional approaches to study habitat use in Pugettia producta, a marine crab that sequesters pigments from the algae it inhabits and consumes to camouflage with different colored algal habitats. Pugettia from different habitats differ in size and color; individuals living in red intertidal algae are small and red, whereas crabs in amber-colored kelp forests are larger and more amber. We examine the developmental causes (effects of size and experience) and the functional consequences (growth and mortality rates) of size-specific habitat use in Pugettia. We demonstrate that positive preference induction may be a mechanism facilitating size-specific habitat use: prior feeding experience with kelp (in the field or laboratory) increases habitat preferences for kelp but only for larger crabs. Habitat use also has important fitness consequences; small red crabs grow equally fast on both kelp and red algae but suffer much higher mortality in kelp; large red crabs grow faster on kelp diets relative to red algae but experience only marginally higher mortality in kelp. Thus, habitat-specific mortality rates may explain the use of intertidal red algal habitats by small crabs, whereas reduced growth of large crabs on red algae may help trigger shifts to subtidal kelp habitats. Size-specific functional consequences of habitat use may select for developmental processes--such as positive preference induction--that facilitate shifts in habitat use in Pugettia and other phenotypically plastic organisms that shift habitats through ontogeny. Copyright 2010, Oxford University Press.

DASH Score and Subsequent Risk of Coronary Artery Disease: The Findings From Million Veteran Program

While adherence to healthful dietary patterns has been associated with a lower risk of coronary artery disease (CAD) in the general population, limited data are available among US veterans. We tested the hypothesis that adherence to Dietary Approach to Stop Hypertension (DASH) food pattern is associated with a lower risk of developing CAD among veterans. We analyzed data on 153 802 participants of the Million Veteran Program enrolled between 2011 and 2016. Information on dietary habits was obtained using a food frequency questionnaire at enrollment. We used electronic health records to assess the development of CAD during follow-up. Of the 153 802 veterans who provided information on diet and were free of CAD at baseline, the mean age was 64.0 (SD=11.8) years and 90.4% were men. During a mean follow-up of 2.8 years, 5451 CAD cases occurred. The crude incidence rate of CAD was 14.0, 13.1, 12.6, 12.3, and 11.1 cases per 1000 person-years across consecutive quintiles of Dietary Approach to Stop Hypertension score. Hazard ratios (95% confidence interval) for CAD were 1.0 (ref), 0.91 (0.84-0.99), 0.87 (0.80-0.95), 0.86 (0.79-0.94), and 0.80 (0.73-0.87) from the lowest to highest quintile of Dietary Approach to Stop Hypertension score controlling for age, sex, body mass index, race, smoking, exercise, alcohol intake, and statin use (P linear trend, <0.0001). Our data are consistent with an inverse association between Dietary Approach to Stop Hypertension diet score and incidence of CAD among US veterans

Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)

Moderate alcohol consumption has been associated with a lower risk of coronary artery disease (CAD) in the general population but has not been well studied in US veterans. We obtained self-reported alcohol consumption from Million Veteran Program participants. Using electronic health records, CAD events were defined as 1 inpatient or 2 outpatient diagnosis codes for CAD, or 1 code for a coronary procedure. We excluded participants with prevalent CAD (n = 69,995) or incomplete alcohol information (n = 8,449). We used a Cox proportional hazards model to estimate hazard ratios and 95% confidence intervals for CAD, adjusting for age, gender, body mass index, race, smoking, education, and exercise. Among 156,728 participants, the mean age was 65.3 years (standard deviation = 12.1) and 91% were men. There were 6,153 CAD events during a mean follow-up of 2.9 years. Adjusted hazard ratios (95% confidence intervals) for CAD were 1.00 (reference), 1.02 (0.92 to 1.13), 0.83 (0.74 to 0.93), 0.77 (0.67 to 0.87), 0.71 (0.62 to 0.81), 0.62 (0.51 to 0.76), 0.58 (0.46 to 0.74), and 0.95 (0.85 to 1.06) for categories of never drinker; former drinker; current drinkers of ≤0.5 drink/day, >0.5 to 1 drink/day, >1 to 2 drinks/day, >2 to 3 drinks/day, and >3 to 4 drinks/day; and heavy drinkers (>4 drinks/day) or alcohol use disorder, respectively. For a fixed amount of ethanol, intake at ≥3 days/week was associated with lower CAD risk compared with ≤1 day/week. Beverage preference (beer, wine, or liquor) did not influence the alcohol-CAD relation. Our data show a lower risk of CAD with light-to-moderate alcohol consumption among US veterans, and drinking frequency may provide a further reduction in risk