Got Diabetes? With Us, You\u27ll Have Complete Diabetic Care

AIM: By April 2016, we aim to improve Complete Diabetic Care of Thursday JHAP Clinic\u27s patients with diabetes by 50%. * These authors contributed equallyhttps://jdc.jefferson.edu/patientsafetyposters/1007/thumbnail.jp

Got Sugar? Pharmacist Intervention to Improve A1c

AIM: Within 6 months, we aim to decrease by 10% the number of our diabetic patients with an A1c \u3e8 through Clinical Pharmacist referrals.https://jdc.jefferson.edu/patientsafetyposters/1033/thumbnail.jp

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

available in PMC 2011 February 3.MCL-1 has emerged as a major oncogenic and chemoresistance factor. A screen of stapled peptide helices identified the MCL-1 BH3 domain as selectively inhibiting MCL-1 among the related anti-apoptotic Bcl-2 family members, providing insights into the molecular determinants of binding specificity and a new approach for sensitizing cancer cells to apoptosis.National Institutes of Health (U.S.) (NIH award 5RO1GM084181)National Institutes of Health (U.S.) (NIH grant 5P01CA92625)National Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award 1F31CA144566)Burroughs Wellcome Fund (Career Award

Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases

The nuclear lamina, along with associated nuclear membrane proteins, is a nexus for regulating signaling in the nucleus. Numerous human diseases arise from mutations in lamina proteins, and experimental models for these disorders have revealed aberrant regulation of various signaling pathways. Previously, we reported that the inner nuclear membrane protein Lem2, which is expressed at high levels in muscle, promotes the differentiation of cultured myoblasts by attenuating ERK signaling. Here, we have analyzed mice harboring a disrupted allele for the Lem2 gene (Lemd2). No gross phenotypic defects were seen in heterozygotes, although muscle regeneration induced by cardiotoxin was delayed. By contrast, homozygous Lemd2 knockout mice died by E11.5. Although many normal morphogenetic hallmarks were observed in E10.5 knockout embryos, most tissues were substantially reduced in size. This was accompanied by activation of multiple MAP kinases (ERK1/2, JNK, p38) and AKT. Knockdown of Lem2 expression in C2C12 myoblasts also led to activation of MAP kinases and AKT. These findings indicate that Lemd2 plays an essential role in mouse embryonic development and that it is involved in regulating several signaling pathways. Since increased MAP kinase and AKT/mTORC signaling is found in other animal models for diseases linked to nuclear lamina proteins, LEMD2 should be considered to be another candidate gene for human disease

A 57 Year-old Man With Prolonged Shortness of Breath and Fevers

Case Presentation A 57 year-old Caucasian male was initially admitted to MethodistHospital from an outside hospital for dehydration, increasedheart rate, and weight loss. He has a past medical history ofcoronary artery disease status post myocardial infarction andcoronary artery bypass graft, congestive heart failure, paroxysmalatrial fibrillation on coumadin, diabetes type II on insulin, andan orthotopic liver transplant in 1997 for end-stage liver diseasesecondary to hepatitis C virus and alpha-1 antitrypsin disorder

An infinite chainmail of M6L6 metallacycles featuring multiple Borromean links

Borromean rings or links are topologically complex assemblies of three entangled rings where no two rings are interlinked in a chain-like catenane, yet the three rings cannot be separated. We report here a metallacycle complex whose crystalline network forms the first example of a new class of entanglement. The complex is formed from the self-assembly of CuBr2 with the cyclotriveratrylene-scaffold ligand (±)-tris(iso-nicotinoyl)cyclotriguaiacylene. Individual metallacycles are interwoven into a two-dimensional chainmail network where each metallacycle exhibits multiple Borromean-ring-like associations with its neighbours. This only occurs in the solid state, and also represents the first example of a crystalline infinite chainmail two-dimensional network. Crystals of the complex were twinned and have an unusual hollow tubular morphology that is likely to result from a localized dissolution-recrystallization proces