Two-Component Structure of the Hbeta Broad-Line Region in Quasars. I. Evidence from Spectral Principal Component Analysis

We report on a spectral principal component analysis (SPCA) of a sample of 816 quasars, selected to have small Fe II velocity shifts with spectral coverage in the rest wavelength range 3500--5500 \AA. The sample is explicitly designed to mitigate spurious effects on SPCA induced by Fe II velocity shifts. We improve the algorithm of SPCA in the literature and introduce a new quantity, \emph{the fractional-contribution spectrum}, that effectively identifies the emission features encoded in each eigenspectrum. The first eigenspectrum clearly records the power-law continuum and very broad Balmer emission lines. Narrow emission lines dominate the second eigenspectrum. The third eigenspectrum represents the Fe II emission and a component of the Balmer lines with kinematically similar intermediate velocity widths. Correlations between the weights of the eigenspectra and parametric measurements of line strength and continuum slope confirm the above interpretation for the eigenspectra. Monte Carlo simulations demonstrate the validity of our method to recognize cross talk in SPCA and firmly rule out a single-component model for broad Hbeta. We also present the results of SPCA for four other samples that contain quasars in bins of larger Fe II velocity shift; similar eigenspectra are obtained. We propose that the Hbeta-emitting region has two kinematically distinct components: one with very large velocities whose strength correlates with the continuum shape, and another with more modest, intermediate velocities that is closely coupled to the gas that gives rise to Fe II emission.Comment: 22 pages, 17 figures, accepted for publication in The Astrophysical Journa

Regulation of B cell fate by chronic activity of the IgE B cell receptor.

IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR). In the absence of cognate antigen, the IgE BCR promoted terminal differentiation of B cells into plasma cells (PCs) under cell culture conditions mimicking T cell help. This antigen-independent PC differentiation involved multiple IgE domains and Syk, CD19, BLNK, Btk, and IRF4. Disruption of BCR signaling in mice led to consistently exaggerated IgE+ germinal center (GC) B cell but variably increased PC responses. We were unable to confirm reports that the IgE BCR directly promoted intrinsic apoptosis. Instead, IgE+ GC B cells exhibited poor antigen presentation and prolonged cell cycles, suggesting reduced competition for T cell help. We propose that chronic BCR activity and access to T cell help play critical roles in regulating IgE responses

Anomalous aspects of magnetosheath flow and of the shape and oscillations of the magnetopause during an interval of strongly northward interplanetary magnetic field

On 15 Feb. 1978, the orientation of the interplanetary magnetic field (IMF) remained steadily northward for more than 12 hours. The ISEE 1 and 2 spacecraft were located near apogee on the dawn side flank of the magnetotail. IMP 8 was almost symmetrically located in the magnetosheath on the dusk flank and IMP 7 was upstream in the solar wind. Using plasma and magnetic field data, we show the following: (1) the magnetosheath flow speed on the flanks of the magnetotail steadily exceeded the solar wind speed by 20 percent; (2) surface waves with approximately a 5-min period and very non-sinusoidal waveform were persistently present on the dawn magnetopause and waves of similar period were present in the dusk magnetosheath; and (3) the magnetotail ceased to flare at an antisunward distance of 15 R(sub E). We propose that the acceleration of the magnetosheath flow is achieved by magnetic tension in the draped field configuration for northward IMF and that the reduction of tail flaring is consistent with a decreased amount of open magnetic flux and a larger standoff distance of the subsolar magnetopause. Results of a three-dimensional magnetohydrodynamic simulation support this phenomenological model

Selection for Lean Growth Rate in a Synthetic Line of YorkshireMeishan Pigs 1. Selection Pressure Applied and Direct Response

Selection for lean growth rate (LGR) was conducted for four generations in a synthetic line of YorkshireMeishan pigs. In the select line, seven boars and 20 gilts with the highest LGR were selected from each generation to produce the subsequent generation. A contemporaneous control line was maintained by randomly selecting five boars and 15 gilts to produce the next generation. Inbreeding coefficients averaged .198 and .207 for the select and control line pigs and .173 and .162 for the select and control line dams, respectively, in the fourth generation. LGR was estimated from ultrasound measures of 10 th -rib backfat thickness and longissimus muscle area from 1,057 pigs. These pigs were sired by 58 boars and out of 133 sows. The generation interval was 13 months and the average selection differential per generation was 1.1 phenotypic standard deviation units for LGR. Heritability and response were estimated from the deviation of select line from the control line and multiple trait derivative free restricted maximum likelihood (MTDFREML) on the same material. Realized heritability was .29 ± .12 for LGR in the control line. Corresponding estimates from MTDFREML were .32 and .37. The estimate of direct genetic change per generation using the deviation from the control line was 9.4 g/day for LGR. Corresponding estimates from MTDFREML were similar but were more precisely estimated

Systematic Literature Review of AbobotulinumtoxinA in Clinical Trials for Blepharospasm and Hemifacial Spasm

Background: The aim was to elucidate clinical trial efficacy, safety, and dosing practices of abobotulinumtoxinA (ABO) treatment in adult patients with blepharospasm and hemifacial spasm. To date, most literature reviews for blepharospasm and hemifacial spasm have examined the effectiveness of all botulinum neurotoxin type A products as a class. However, differences in dosing units and recommended schemes provide a clear rationale for reviewing each product separately. Methods: A systematic literature review was performed to identify randomized controlled trials and other comparative clinical studies of ABO in the treatment of blepharospasm and hemifacial spasm published in English between January 1991 and March 2015. Medical literature databases (PubMed, Cochrane library, EMBASE) were searched. A total of five primary publications that evaluated ABO for the management of blepharospasm and hemifacial spasm were identified and summarized. Results: Data included 374 subjects with blepharospasm and 172 subjects with hemifacial spasm treated with ABO. Total ABO doses ranged between 80 and 340 U for blepharospasm and 25 and 85 U for hemifacial spasm, depending on the severity of the clinical condition. All studies showed statistically significant benefits for the treatment of blepharospasm and hemifacial spasm. ABO was generally well tolerated across the individual studies. Adverse events considered to be associated with ABO treatment included: ptosis, tearing, blurred vision, double vision, dry eyes, and facial weakness. Discussion: These data from 5 randomized clinical studies represents the available evidence base of ABO in blepharospasm and hemifacial spasm. Future studies in this area will add to this evidence base

Systematic Literature Review of AbobotulinumtoxinA in Clinical Trials for Lower Limb Spasticity

AbstractTo elucidate clinical trial efficacy, safety, and dosing practices of AbobotulinumtoxinA (ABO) treatment in adult patients with lower limb spasticity.A systematic literature review was performed to identify randomized controlled trials of ABO in the treatment of adult lower limb spasticity.Of the 295 records identified, 6 primary publications evaluated ABO for the management of lower limb spasticity of various etiologies and were evaluated. Total ABO doses ranged between 500 and 2000 U for lower limb spasticity, depending on the muscles injected. All studies in lower limb spasticity showed statistically significant reduction in muscle tone based on Modified Ashworth Scale of ABO versus placebo. Significant effects on active movement and pain were demonstrated albeit less consistently. ABO was generally well tolerated across the individual studies; most adverse events reported were considered unrelated to treatment. Treatment-related adverse events included but not limited to fatigue, local pain at injection site, hypertonia, dry mouth, weakness of the noninjected muscle, abnormal gait, and urinary tract infection.These data from 6 randomized clinical studies provide the beginnings of an evidence base for the use of ABO to reduce lower limb spasticity. Ongoing studies in this area will add to this evidence base

Neither dust nor black carbon causing apparent albedo decline in Greenland\u27s dry snow zone: Implications for MODIS C5 surface reflectance

Remote sensing observations suggest Greenland ice sheet (GrIS) albedo has declined since 2001, even in the dry snow zone. We seek to explain the apparent dry snow albedo decline. We analyze samples representing 2012–2014 snowfall across NW Greenland for black carbon and dust light-absorbing impurities (LAI) and model their impacts on snow albedo. Albedo reductions due to LAI are small, averaging 0.003, with episodic enhancements resulting in reductions of 0.01–0.02. No significant increase in black carbon or dust concentrations relative to recent decades is found. Enhanced deposition of LAI is not, therefore, causing significant dry snow albedo reduction or driving melt events. Analysis of Collection 5 Moderate Resolution Imaging Spectroradiometer (MODIS) surface reflectance data indicates that the decline and spectral shift in dry snow albedo contains important contributions from uncorrected Terra sensor degradation. Though discrepancies are mostly below the stated accuracy of MODIS products, they will require revisiting some prior conclusions with C6 data