Response to Interferon-Beta Treatment in Afro-Caribbeans with Multiple Sclerosis

Background. Multiple sclerosis (MS) patients of African ancestry have a more aggressive disease course than white patients and could be resistant to interferon-beta (INFB). Methods. We studied the impact of INFB in treatment-naive Afro-Caribbean (AC) with clinically definite MS using our European Database for Multiple Sclerosis (EDMUS) (2003–2010). Main outcome measures were annual relapse rate after 2 years of treatment, proportion of exacerbation-free subjects 48 weeks after initiating INFB, and time to first relapse. Results. 76 AC-MS (59F/17M) were identified. Annual relapse rate of 1.29 decreased to 0.83 (−35.6%) after 2 years of treatment. The proportion of relapse-free patients at 48 weeks was 46.2%. Median time to first relapse was 52 weeks. Conclusion. INFB is not strong enough to control AC-MS patients in many cases which is problematic in a population of worse MS prognosis

Estimates of Outcomes Up to Ten Years after Stroke: Analysis from the Prospective South London Stroke Register

Charles Wolfe and colleagues collected data from the South London Stroke Register on 3,373 first strokes registered between 1995 and 2006 and showed that between 20% and 30% of survivors have poor outcomes up to 10 years after stroke

COVID-19, systemic crisis, and possible implications for the wild meat trade in sub-Saharan Africa

Wild animals play an integral and complex role in the economies and ecologies of many countries across the globe, including those of West and Central Africa, the focus of this policy perspective. The trade in wild meat, and its role in diets, have been brought into focus as a consequence of discussions over the origins of COVID-19. As a result, there have been calls for the closure of China’s “wet markets”; greater scrutiny of the wildlife trade in general; and a spotlight has been placed on the potential risks posed by growing human populations and shrinking natural habitats for animal to human transmission of zoonotic diseases. However, to date there has been little attention given to what the consequences of the COVID-19 economic shock may be for the wildlife trade; the people who rely on it for their livelihoods; and the wildlife that is exploited. In this policy perspective, we argue that the links between the COVID-19 pandemic, rural livelihoods and wildlife are likely to be more complex, more nuanced, and more far-reaching, than is represented in the literature to date. We develop a causal model that tracks the likely implications for the wild meat trade of the systemic crisis triggered by COVID-19. We focus on the resulting economic shockwave, as manifested in the collapse in global demand for commodities such as oil, and international tourism services, and what this may mean for local African economies and livelihoods. We trace the shockwave through to the consequences for the use of, and demand for, wild meats as households respond to these changes. We suggest that understanding and predicting the complex dynamics of wild meat use requires increased collaboration between environmental and resource economics and the ecological and conservation sciences

Social Correlates of and Reasons for Primate Meat Consumption in Central Amazonia

Traditionally, humans have consumed nonhuman primates in many places, including throughout the Amazon region. However, primate consumption rates are changing with rising urbanization and market access. We characterize primate consumption in central Amazonia using 192 qualitative interviews with inhabitants in three rural villages and in the city of Tefé. We used a generalized linear model to investigate how individual consumer characteristics, such as age and gender, and livelihoods affected primate consumption. We also used principal coordinate analysis (PCoA), and word clouds and network text analyses, to describe reasons people gave for eating or avoiding primates. Our results show that men were more likely to say that they eat primates than women, and that the probability that a person said that they eat primates correlated positively with the percentage of their life lived in rural areas. People gave sentiment and ethical reasons not to eat primates. Custom influenced whether people said they eat primates both positively and negatively, while taste positively influenced whether people said they eat primates. A preference for other wild meats in rural areas, and for domestic meats in cities negatively influenced whether people said they eat primates. People also cited the perceptions that primates have a human-like appearance and that primate meat is unhealthy as reasons not to eat primates. People in urban areas also cited conservation attitudes as reasons for not eating primates. Our findings provide an understanding of factors influencing primate consumption in our study area and will be useful for designing tailored conservation initiatives by reducing hunting pressure on primates in rural settings and increasing the effectiveness of outreach campaigns in urban centers

Probing the structural factors influencing columnar mesophase formation and stability in triphenylene discotics

Series of structurally related substituted triphenylene derivatives were designed and synthesised to interrogate key features which determine mesophase formation and stability, and to challenge the general conclusions previously proposed by us and others. It is apparent that no single, simple principle can be universally applied

Understanding the value and limits of nature-based solutions to climate change and other global challenges

There is growing awareness that ‘nature-based solutions' (NbS) can help to protect us from climate change impacts while slowing further warming, supporting biodiversity and securing ecosystem services. However, the potential of NbS to provide the intended benefits has not been rigorously assessed. There are concerns over their reliability and cost-effectiveness compared to engineered alternatives, and their resilience to climate change. Trade-offs can arise if climate mitigation policy encourages NbS with low biodiversity value, such as afforestation with non-native monocultures. This can result in maladaptation, especially in a rapidly changing world where biodiversity-based resilience and multi-functional landscapes are key. Here, we highlight the rise of NbS in climate policy—focusing on their potential for climate change adaptation as well as mitigation—and discuss barriers to their evidence-based implementation. We outline the major financial and governance challenges to implementing NbS at scale, highlighting avenues for further research. As climate policy turns increasingly towards greenhouse gas removal approaches such as afforestation, we stress the urgent need for natural and social scientists to engage with policy makers. They must ensure that NbS can achieve their potential to tackle both the climate and biodiversity crisis while also contributing to sustainable development. This will require systemic change in the way we conduct research and run our institutions

Nature-based solutions in Bangladesh: evidence of effectiveness for addressing climate change and other sustainable development goals

Many lower-income countries are highly vulnerable to the impacts of natural disasters and climate change, due to their geographical location and high levels of poverty. In response, they are developing climate action plans that also support their sustainable development goals, but conventional adaptation approaches such as hard flood defenses can be expensive and unsustainable. Nature-based solutions (NbS) could provide cost-effective options to address these challenges but policymakers lack evidence on their effectiveness. To address this knowledge gap, we focused on Bangladesh, which is exceptionally vulnerable to cyclones, relative sea-level rise, saline intrusion, floods, landslides, heat waves and droughts, exacerbated by environmental degradation. NbS have been implemented in Bangladesh, but there is no synthesis of the outcomes in a form accessible to policymakers. We therefore conducted a systematic review on the effectiveness of NbS for addressing climate and natural hazards, and the outcomes for other sustainable development goals. Research encompasses protection, restoration and participatory management of mangroves, terrestrial forests and wetlands, as well as conservation agriculture and agro-forestry, but there is an evidence gap for urban green infrastructure. There is robust evidence that, if well-designed, these NbS can be effective in reducing exposure to natural disasters, adapting to climate change and reducing greenhouse gas emissions while empowering marginalized groups, reducing poverty, supporting local economies and enhancing biodiversity. However, we found short-term trade-offs with local needs, e.g. through over-harvesting and conversion of ecosystems to aquaculture or agriculture. To maximize NbS benefits while managing trade-offs, we identified four enabling factors: support for NbS in government policies; participatory delivery involving all stakeholders; strong and transparent governance; and provision of secure finance and land tenure, in line with international guidelines. More systematic monitoring of NbS project outcomes is also needed. Bangladesh has an opportunity to lead the way in showing how high quality NbS can be deployed at landscape scale to tackle sustainable development challenges in low to middle income countries, supporting a Green Economic Recovery. Our evidence base highlights the value of protecting irreplaceable natural assets such as mangroves, terrestrial forests and wetlands, and the non-market benefits they deliver, in national planning policies