411 research outputs found
An agent-based framework for selection of partners in dynamic virtual enterprises
Get PDFAdvances in computer networking technology and open system standards have made practically
feasible to create and manage virtual enterprises. A virtual enterprise, VE, is usually defined as a
temporary alliance of enterprises that come together to share their skills, core competencies, and
resources in order to better respond to business opportunities, and whose cooperation is supported by
computer networks.
The materialization of this paradigm, although enabled by recent advances in communication
technologies, computer networks and logistics, requires an appropriate architectural framework and
support tools.
In this paper we propose an agent-based model of a dynamic VE to support the different selection
processes that are used in selecting the partners for a dynamic VE, where the partners of a VE are
represented by agents. Such a framework will form the basis for tools that provide automated support
for creation, and operation, of dynamic virtual enterprises
Repercusiones de la entrada en la C.E. sobre el mercado de vinos de calidad en Cataluña
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Differentiated adsorption of thiobenzoic acid and thiobenzamide on silver nanoparticles determined by SERS spectroscopy.
Get PDFPolítica de acceso abierto tomada de: https://v2.sherpa.ac.uk/id/publication/15140?template=romeo
(Submitted version)Surface-enhanced Raman scattering of thiobenzoic acid and thiobenzamide
have been recorded on three different silver colloids in order to find the
chemical species responsible for the spectra and to detect differences in the
adsorption with respect to their oxygen counterparts, benzoic acid and
benzamide, respectively. Very significant and unexpected shifts of opposite
sign between the Raman and SERS wavenumbers have been detected. By
comparing the experimental and DFT calculated wavenumbers, it can be
concluded that the acid is bonded to the metal as thiobenzoate through the sulfur
atom with unidentate coordination. SERS spectra of thiobenzamide can be
explained by assuming that it is adsorbed as azanion, like in the case of
benzamide, linking to the metal through the sulfur and nitrogen atoms of the
ionized thiocarboxamide group. In order to support these conclusions,
B3LYP/LanL2DZ force field calculations for different complexes of silver
cations with the thiobenzoate anion, the neutral thiobenzamide as well as its
azanion have been carried out. Additionally, the 8a;nring mode is the most
enhanced band in the SERS of both adsorbates pointing to the participation of
a metal-to-molecule resonant charge transfer mechanism.Spanish MINECO/FEDER (CTQ2015-65816-R)
Junta de Andalucía/FEDER (UMA18-FEDERJA-049 and P18-RT-4592)
Ramón Areces Foundatio
Expression patterns for nicotinic acetylcholine receptor subunit genes in smoking-related lung cancers
Full text linkCigarette smoking is associated with increased risk for all histologic types of
lung cancer, but why the strength of this association is stronger for squamous cell
carcinoma than adenocarcinoma of the lung (SQC-L, ADC-L) is not fully understood.
Because nicotine and tobacco-specific nitrosamines contribute to carcinogenesis by
activating nicotinic acetylcholine receptors (nAChRs) on lung tumors and epithelial
cells, we investigated whether differential expression of nAChR subtypes in these
tumors could explain their different association with smoking. Expression of nAChR
subunit genes in paired tumor and non-tumor lung specimens from 40 SQC-L and 38
ADC-L patients was analyzed by quantitative PCR. Compared to normal lung, both
tumors share: i) transcriptional dysregulation of CHRNA3/CHRNA5/CHRNB4 (α3,
α5, β4 subunits) at the chromosomal locus that predisposes to lung cancer; and ii)
decreased expression of CHRFAM7A (dupα7 subunit); this last subunit negatively
modulates α7-nAChR activity in oocytes. In contrast, CHRNA7 (α7 subunit) expression
was increased in SQC-L, particularly in smokers and non-survivors, while CHRNA4
(α4 subunit) expression was decreased in ADC-L. Thus, over-representation of
cancer-stimulating α7-nAChR in SQC-L, also potentiated by smoking, and underrepresentation
of cancer-inhibiting α4β2-nAChR in ADC-L could explain the different
tobacco influences on the tumorigenic process in each cancer typeThis study was supported by grants to C. Montiel and F. Arnalich from the Ministry of Economy, Industry and Competitiveness, Government of Spain (SAF2014-56623-R) and Foundation “Mutua Madrileña Investigación Biomédica” (FMM2011), Spain. A.B.
is recipient of a fellowship (Beca FPI, Universidad Autónoma Madrid). J.L.C. and C.M.S. are recipients of fellowships (Beca FPU from Ministerio de Educación, Cultura y Deporte and Beca FPI from Ministry of Economy, Industry and Competitiveness, Government of Spain, respectively
La Constitución Europea. Una visión desde Euskadi
Get PDFJornada: La Constitución Europea. Una visión desde Euskadi
15 de febrero de 200
Las cuevas de la Sierra de Atapuerca y el uso humano del paisaje kárstico durante el Pleistoceno (Burgos, España)
Get PDFEl karst de la Sierra de Atapuerca representa un interesante sistema multinivel, inactivo y heredado de antiguos niveles de base plio-pleistocenos, que alberga los enclaves prehistóricos más importantes para el conocimiento del poblamiento antiguo en Eurasia, y que fue declarado Patrimonio de la Humanidad en 2000 por la UNESCO. Estas cuevas se originan a partir de conductos subhorizontales con paleodrenajes en sentido SN, localizándose la zona de descarga en la cabecera del río Pico. Los conductos están organizados en tres niveles principales que aparecen colgados entre 90 y 60 m sobre el actual cauce del río Arlanzón, coincidiendo con los niveles de base generados por sus terrazas fluviales T2, T3 y T5. La incisión fluvial liberó de las aguas los conductos superiores mientras se excavaban los niveles inferiores del karst. Las cuevas que iban quedando accesibles fueron utilizadas por la fauna y los homininos, conservando un registro arqueo-paleontológico de más de 1,2 Ma
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