A new paradigm in functionally graded adhesives

To fully realize the benefits of advanced composites, mechanical fasteners must be supplanted by more efficient technologies such as adhesive bonding. The promise of functionally graded adhesives to provide particularly high levels of performance in this context has been recognized for decades, but a means of generating stable, high performance adhesive joints with arbitrary gradations in mechanical properties has proved elusive. Please click Additional Files below to see the full abstract

Acoustic pharyngometry: clinical and instrumental correlations in sleep disorders

Summary Matteo Gelardi 1 , Alessandro Maselli del Giudice 2 , Francesco Cariti 3 , Michele Cassano 4 , Aline Castelante Farras 5 , Maria Luisa Fiorella 6 , Pasquale Cassano 7 1 ENT specialist (Physician of the Bari University Otorhinolaryngology Department - Italy) 2 Physician (ENT Resident - Bari University - Italy) 3 Physician (ENT Resident - Bari University - Italy) 4 ENT specialist (Researcher of the Foggia University Otorhinolaryngology Department - Italy) 5 ENT specialist (Fellow of the Foggia University Otorhinolaryngology Department - Italy) 6 ENT specialist (Researcher of the Bari University Otorhinolaryngology Department - Italy) 7 ENT and Audiology specialist (Head of the Foggia University Otorhinolaryngology Department and Full Professor of Otorhinolaryngology at Foggia University - Italy)Bari University - Italy; Foggia University - ItalyDr. Michele Cassano Via: Crispi 34/C CEP: 70123 Bari - Italy. Telephone: 00xx39-080-5235508/ 00xx39-3388105268 Fax: 00xx39-080-5211318. Dra. Aline Castelante Farras Rua Sete de Setembro, 676 Centro Vila Velha - ES Telefone: 27-32393661 E-mail: [email protected] [email protected] Paper submitted to the ABORL-CCF SGP (Management Publications System) on July 29th, 2005 and accepted for publication on November 3th, 2006. cod. 567

New developments in dual cure epoxies

Direct write 3D printing provides an exciting new means of generating novel structures from thermosetting resins via an additive approach. Initial efforts along these lines demonstrated the preparation of homogenous, high quality parts. More recent work has shown that it is possible to modulate the properties of these parts locally through changes in orientation of high aspect ratio fillers. In this work, we present complementary developments related to resin chemistry that should provide practitioners of direct write 3D printing with additional options as far as the realization of functional gradations is concerned. This is accomplished via the creation of so-called “dual cure” resins. Here this term refers to materials that undergo thermal cure in a similar fashion to many conventional resins. Then, in a second step, the selective exposure of these materials to high energy radiation (gamma rays, electrons, etc.) results in further increases in local crosslink density, altering thermomechanical performance and providing a means of inducing arbitrary gradations in properties in a post-processing step. A number of different families of dual cure resins have been explored and are presented here, as well as data concerning changes in thermal and mechanical performance as a function of the details of the dual curing process. Preliminary efforts giving evidence of the generation of stable functional gradations in practice are also described. Ongoing and future efforts are focused on the optimization of these systems and the incorporation of their cure-dependent mechanical behavior into simulations in order to enable design optimization

A faringometria acústica: correlações clínico-instrumentais nos distúrbios do sono

A faringometria acústica representa um método atual baseado no principio físico da reflexão acústica, útil à análise volumétrica do espaço orofaringolaringotraqueal. OBJETIVO: Este estudo se propõe a avaliar as variações dos parâmetros faringométricos em indivíduos portadores de distúrbios respiratórios do sono (DRS), para estabelecer uma relação entre as variações morfovolumétricas do espaço orofaringolaríngeo e a existência e gravidade da patologia. FORMA DE ESTUDO: Clínico e experimental. MATERIAL E MÉTODO: Foram examinados 110 pacientes, 70 com DRS e 40 normais, durante o período de Junho/04 a Junho/05. Todos os pacientes foram submetidos à faringometria acústica que permitiu uma avaliação da área oro e hipofaríngea através de um gráfico explicativo. RESULTADOS: Os parâmetros obtidos nos pacientes com DRS mostraram uma importante diferença com respeito ao grupo controle, principalmente na amplitude da I onda (significantemente menor nos pacientes com macroglossia), na extensão do segmento OF, na amplitude do segmento OF e na área hipofaríngea. COLCLUSÃO: A faringometria acústica, mesmo não sendo uma técnica padronizada, pode auxiliar no diagnóstico das síndromes obstrutivas do sono, na localização dos possíveis pontos de obstrução e da gravidade da patologia, e no monitoramento dos pacientes submetidos a cirurgias desobstrutivas das vias aéreas superiores

Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography

partially_open10noThe optical characterization of malignant and benign breast lesions is presented. Time-resolved transmittance measurements were performed in the 630-1060 nm range by means of a 7-wavelength optical mammograph, providing both imaging and spectroscopy information. A total of 62 lesions were analyzed, including 33 malignant and 29 benign lesions. The characterization of breast lesions was performed applying a perturbation model based on the high-order calculation of the pathlength of photons inside the lesion, which led to the assessment of oxy- and deoxy- hemoglobin, lipids, water and collagen concentrations. Significant variations between tumor and healthy tissue were observed in terms of both absorption properties and constituents co ncentration. In particular, benign lesions and tumors show a statistically significant discrimination in terms of absorption at several wavelengths and also in terms of oxy-hemoglobin and collagen content.G. Quarto; L. Spinelli; A. Pifferi; A. Torricelli; R. Cubeddu; F. Abbate; N. Balestreri; S. Menna; E. Cassano; P. TaroniQuarto, Giovanna; Spinelli, Lorenzo; Pifferi, ANTONIO GIOVANNI; Torricelli, Alessandro; Cubeddu, Rinaldo; F., Abbate; N., Balestreri; S., Menna; E., Cassano; Taroni, Paol

Complete Metabolic Response with Recanalization of Portal Vein Tumor Thrombosis after Sunitinib in a Patient with Advanced Hepatocellular Carcinoma

The prognosis of patients with advanced hepatocellular carcinoma (HCC) is very poor. The outcome of these patients is particularly bleak when the disease is complicated by portal vein tumor thrombosis (PVTT), since the increased portal pressure often causes serious gastrointestinal bleedings. Before the introduction of sorafenib (SOR), a tyrosine kinase inhibitor, no effective treatment was available for patients with advanced disease. SOR is now considered the standard treatment even for patients with tumor thrombosis, although the well-known interference between tyrosine kinase inhibitors and the coagulation pathway calls for caution against their use in this setting. Here, we report the case of a 74-year-old male patient with advanced HCC and PVTT treated with sunitinib (SUN), another multikinase inhibitor. During the third cycle, our patient experienced a life-threatening hematemesis with hemorrhagic shock that required intensive care treatment and SUN discontinuation. However, he completely recovered, and the PET/CT scan performed 1 year after the adverse effect demonstrated no evidence of the tumor together with portal vein recanalization. The short course of SUN causing both tumor response and gastrointestinal bleeding warrants further studies on the effectiveness of SUN in this setting as well as on the duration of treatment with multikinase inhibitors in patients with tumor thrombosis

Operator learning curve for transradial liver cancer embolization: implications for the initiation of a transradial access program

PURPOSEWe aimed to analyze transradial access (TRA) learning curve on patients undergoing hepatic chemoembolization, investigating the relationship between procedural volumes and various benchmarks of procedural success.METHODSWe enrolled 60 consecutive patients who received two unilobar hepatic chemoembolizations within a 4-week interval performed by a single interventional radiologist, highly-trained in conventional transfemoral access (TFA) procedures, but without any previous practical experience in TRA procedures and with a preliminary 2-day theoretical training only. Consecutive patients were prospectively enrolled and analyzed in 3 groups: A (cases 1 to 20), B (cases 21 to 40), and C (cases 41 to 60). All patients underwent one hepatic chemoembolization using TRA and the other one using TFA in random order. All TFA procedures performed by the same operator in the same series of patients were considered as the control group. Primary endpoint was to analyze the relationship between TRA procedure operator experience and benchmarks of procedural success, to define the optimal procedural learning curve.RESULTSTechnical success was obtained in all patients, with a crossover rate (radial to femoral access) of 0%. An association between incremental TRA operator experience (in terms of performed procedures) and decrease of preparation, puncture, fluoroscopy, and total examination times was observed. Similarly, inverse associations between incremental TRA operator experience and contrast medium (CM) volumes (P < 0.001) and radiation dose (RD) values (in terms of RAK - Reference Air Kerma) (P < 0.001) were also observed. Compared with TFA, CM volumes and RD values were significantly higher only in group A (cases 1–20). Procedure success remained high in all TRA groups and no significant association between TRA incremental experience and postprocedural outcomes was found. Higher postprocedural complaints at the access route and more limitations in performing basic activities were recorded after TFA vs. TRA (P < 0.001).CONCLUSIONTRA catheterizations can be safely performed in patients treated for liver cancer embolization after a relatively short training in controlled conditions and with a better performance in comparison with TFA. Operator proficiency improves with greater TRA experience, with a threshold needed to overcome the learning curve represented by about 20 procedures

Tolerability of Eribulin and correlation between polymorphisms and neuropathy in an unselected population of female patients with metastatic breast cancer: results of the multicenter, single arm, phase IV PAINTER study

Background Metastatic breast cancer (MBC) is an incurable disease and its treatment focuses on prolonging patients' (pts) overall survival (OS) and improving their quality of life. Eribulin is a microtubule inhibitor that increases OS in pre-treated MBC pts. The most common adverse events (AEs) are asthenia, neutropenia and peripheral neuropathy (PN). Methods PAINTER is a single arm, phase IV study, aimed at evaluating the tolerability of eribulin in MBC pts. Secondary objectives were the description of treatment efficacy and safety, the assessment of the incidence and severity of PN and its association with genetic polymorphisms. Genomic DNA was isolated from blood samples and 15 Single Nucleotide Polymorphisms (SNPs) were genotyped by Taqman specific assays. The association between PN and SNPs were evaluated by Fisher exact test. Results Starting from May 2014 until June 2018 180 pts were enrolled in this study by 20 Italian centers. 170 of these pts could be evaluated for efficacy and toxicity and 159 for polymorphisms analysis. The median age of pts was 60 years old and the biological subtypes were luminal type (64.7%), Her2 positive (18.3%) and triple negative (17%). Pts were pretreated with a median of 5 lines for MBC. The median follow up of this study was 15.4 months with a median number of 4.5 cycles administered (minimum-maximum 1-23). The median overall survival was 12 months. 48.8% of pts experienced a dose reduction, mainly for neutropenia (23.9%) and liver toxicity (12%). 65 pts (38.2%) reported at least one severe toxicity. Neutropenia and neurotoxicity were the most frequent severe AEs (15.3% and 14.7%, respectively); other reported toxicities were osteo-muscular, abdominal or tumor site pain (19.4%), liver toxicity (6.6%), pulmonary toxicity (6.5%) and dermatological toxicity (3.6%). Among the 15 evaluated SNPs, an association with PN was found for rs2233335 and rs7214723. Conclusions Eribulin is a well-tolerated treatment option in MBC. Schedule and dosage modifications were common, but toxicity rarely led to treatment discontinuation. SNPs rs2233335 (G/T and T/T) in the NDRG1 gene and rs7214723 (CC and CT) in the CAMKK1 gene were associated with PN. These findings, if validated, could allow a tailored treatment with eribulin in cancer patients. Trial registration: ClinicalTrials.gov ID: NCT02864030