Generalized optimization models of linguistic laws

Quantitative linguistics studies human language using statistical methods. It aims to build general theories from the statistical laws observed in a wide variety of languages. As part of the scientific method, these theories should be able to make novel predictions. This thesis is based on a family of models of human language. These models have shown to reproduce language laws, such as Zipf's law. They have also been used to make predictions, such as the biases present in child word learning. This family of models is based on the minimization of a cost function. The cost function is defined using a combination of information theoretic measures on a bipartite graph of associations between words (or, more generally, forms) and meanings (more generally, counterparts). It balances between the entropy of words and the mutual information of words and meanings. Entropy is a measure of surprisal, the cost of the speaker, and should be minimized. Mutual information is the amount of information obtained from a meaning while observing a word, the cost of the listener, and it should be maximized. The model is then optimized with a Markov Chain Monte Carlo method at zero temperature. This thesis is centered on two models belonging to this family, the "internal model" and the "external model". This thesis makes several contributions in relation to these models. The mathematical equations defining them are derived, including dynamic equations which reduce the computational complexity of the optimization process. In addition, several techniques are introduced which aim to reduce the significant problem of numerical error due to floating point arithmetic without compromising efficiency. Another contribution is the replication of results obtained by previous models based on this family which had been published originally with replicability issues. The models go through an optimization process. After this process the linguistic laws they can predict are examined, as well as to which degree they can be predicted. A key contribution is that these models are able predict the relationship between the age of a word and its frequency. This prediction is robust and appears in all cases with any combinations of parameters. The effects of several initial conditions in the optimization process is also studied. Finally, a tool has been developed and released as open source with the aim that others can easily replicate these results and investigate other properties of this family of models

The advent and fall of a vocabulary learning bias from communicative efficiency

Biosemiosis is a process of choice-making between simultaneously alternative options. It is well-known that, when sufficiently young children encounter a new word, they tend to interpret it as pointing to a meaning that does not have a word yet in their lexicon rather than to a meaning that already has a word attached. In previous research, the strategy was shown to be optimal from an information theoretic standpoint. In that framework, interpretation is hypothesized to be driven by the minimization of a cost function: the option of least communication cost is chosen. However, the information theoretic model employed in that research neither explains the weakening of that vocabulary learning bias in older children or polylinguals nor reproduces Zipf’s meaning-frequency law, namely the non-linear relationship between the number of meanings of a word and its frequency. Here we consider a generalization of the model that is channeled to reproduce that law. The analysis of the new model reveals regions of the phase space where the bias disappears consistently with the weakening or loss of the bias in older children or polylinguals. The model is abstract enough to support future research on other levels of life that are relevant to biosemiotics. In the deep learning era, the model is a transparent low-dimensional tool for future experimental research and illustrates the predictive power of a theoretical framework originally designed to shed light on the origins of Zipf’s rank-frequency law.DCC and RFC are supported by the grant TIN2017-89244-R from MINECO (Ministerio de Economía, Industria y Competitividad). RFC is also supported by the recognition 2017SGR-856 (MACDA) from AGAUR (Generalitat de Catalunya). Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature.Peer ReviewedPostprint (published version

Display activat per moviment fent servir persistència de visió

Aquest projecte té com a objectiu el disseny i implementació d'un display basat en persistència de visió, el qual utilitza moviment per tal d'activar-se i detectar el moment adequat per re-dibuixar el text mostrat. El display es basa en una barra allargada, amb un acceleròmetre en un extrem, i una tira de leds en part de la seva llargada. Els components electrònics són muntats en una placa de circuit imprès i controlats per un microcontrolador tipus Arduino, el qual inclou un mòdul Bluetooth, permetent que el text es pugui canviar enviat missatges via Bluetooth. Aquest document parla sobre les principals alternatives pel que fa a displays basats en persistència de visió, principalment els displays giratoris. A continuació, les diferències amb aquests s'enumeren. Finalment, les varies tecnologies utilitzades en el projecte són explicades, per tal d'introduir antecedents. La següent part cobreix extensivament el disseny i implementació del dispositiu, començant amb una descripció general i continuant amb l'explicació tant del hardware com del software que composen el projecte L'última part del document inclou tot el codi font escrit específicament pel projecte

Magnetic resonance imaging features of canine intradural/extramedullary intervertebral disc extrusion in seven cases.

Intervertebral disc disease, including intervertebral disc extrusions and protrusions, is the most common spinal cord disorder in dogs. Atypical and uncommon intervertebral disc herniations include intradural/intramedullary disc extrusion, intervertebral foraminal disc extrusion and intervertebral disc herniation (Schmorl's node). Intradural/extramedullary disc extrusion is the least common type of intervertebral disc herniation in veterinary medicine, characterized by extruded disc material within the intradural space. To date, only one study has been published in veterinary medicine reporting intradural/extramedullary disc extrusions. In this study, low field MRI was used, and the authors could not find any MRI features to diagnose with confidence an intradural/extramedullary disc location of the extruded disc material. The aim of this study was to describe the high field (1.5T) MRI characteristics of surgically confirmed intradural/extramedullary disc extrusions. This is a retrospective, multicentric and descriptive study. Inclusion criteria was surgical confirmation of intradural/extramedullary disc extrusion by durotomy and complete MRI study of the spine. Seven cases were included. Images were reviewed by a radiology resident and a certified radiologist, with emphasis on the following signs: "Golf-tee sign" (widening of the subarachnoid space cranial and caudal to the lesion), "Beak sign" (pointed and sharp compressive lesion) and "Y sign" (division of the dura and arachnoid layers). MRI showed a "Y sign" in all the cases (7/7) seen from the T2-weighted sagittal views, while "Golf-tee sign" was not recognized in any of the cases (0/7). Additionally, "beak sign" was present in half of the cases (4/7). "Y sign" maybe a reliable MRI feature for identifying intradural/medullary disc extrusions from the MRI study. As the arachnoid is peeled from the dura by the disc herniation there is a splitting of the arachnoid mater and the ventral dura. The intradural disc material will be surrounded by CSF signal intensity margin, giving the appearance of a Y, which can be identified from the T2-weighted sagittal images

Display activat per moviment fent servir persistència de visió

Aquest projecte té com a objectiu el disseny i implementació d'un display basat en persistència de visió, el qual utilitza moviment per tal d'activar-se i detectar el moment adequat per re-dibuixar el text mostrat. El display es basa en una barra allargada, amb un acceleròmetre en un extrem, i una tira de leds en part de la seva llargada. Els components electrònics són muntats en una placa de circuit imprès i controlats per un microcontrolador tipus Arduino, el qual inclou un mòdul Bluetooth, permetent que el text es pugui canviar enviat missatges via Bluetooth. Aquest document parla sobre les principals alternatives pel que fa a displays basats en persistència de visió, principalment els displays giratoris. A continuació, les diferències amb aquests s'enumeren. Finalment, les varies tecnologies utilitzades en el projecte són explicades, per tal d'introduir antecedents. La següent part cobreix extensivament el disseny i implementació del dispositiu, començant amb una descripció general i continuant amb l'explicació tant del hardware com del software que composen el projecte L'última part del document inclou tot el codi font escrit específicament pel projecte

Impact of late presentation of HIV infection on short-, mid- and long-term mortality and causes of death in a multicenter national cohort : 2004-2013

To analyze the impact of late presentation (LP) on overall mortality and causes of death and describe LP trends and risk factors (2004-2013). Cox models and logistic regression were used to analyze data from a nation-wide cohort in Spain. LP is defined as being diagnosed when CD4 < 350 cells/ml or AIDS. Of 7165 new HIV diagnoses, 46.9% (CI:45.7-48.0) were LP, 240 patients died.First-year mortality was the highest (aHR = 10.3[CI:5.5-19.3]); between 1 and 4 years post-diagnosis, aHR = 1.9(1.2-3.0); an

Prediction of long-term outcomes of HIV-infected patients developing non-AIDS events using a multistate approach

Outcomes of people living with HIV (PLWH) developing non-AIDS events (NAEs) remain poorly defined. We aimed to classify NAEs according to severity, and to describe clinical outcomes and prognostic factors after NAE occurrence using data from CoRIS, a large Spanish HIV cohort from 2004 to 2013. Prospective multicenter cohort study. Using a multistate approach we estimated 3 transition probabilities: from alive and NAE-free to alive and NAE-experienced ("NAE development"); from alive and NAE-experienced to death ("Death after NAE"); and from alive and NAE-free to death ("Death without NAE"). We analyzed the effect of different covariates, including demographic, immunologic and virologic data, on death or NAE development, based on estimates of hazard ratios (HR). We focused on the transition "Death after NAE". 8,789 PLWH were followed-up until death, cohort censoring or loss to follow-up. 792 first incident NAEs occurred in 9.01% PLWH (incidence rate 28.76; 95% confidence interval [CI], 26.80-30.84, per 1000 patient-years). 112 (14.14%) NAE-experienced PLWH and 240 (2.73%) NAE-free PLWH died. Adjusted HR for the transition "Death after NAE" was 12.1 (95%CI, 4.90-29.89). There was a graded increase in the adjusted HRs for mortality according to NAE severity category: HR (95%CI), 4.02 (2.45-6.57) for intermediate-severity; and 9.85 (5.45-17.81) for serious NAEs compared to low-severity NAEs. Male sex (HR 2.04; 95% CI, 1.11-3.84), ag

Subcutaneous anti-COVID-19 hyperimmune immunoglobulin for prevention of disease in asymptomatic individuals with SARS-CoV-2 infection: a double-blind, placebo-controlled, randomised clinical trialResearch in context

Summary: Background: Anti-COVID-19 hyperimmune immunoglobulin (hIG) can provide standardized and controlled antibody content. Data from controlled clinical trials using hIG for the prevention or treatment of COVID-19 outpatients have not been reported. We assessed the safety and efficacy of subcutaneous anti-COVID-19 hyperimmune immunoglobulin 20% (C19-IG20%) compared to placebo in preventing development of symptomatic COVID-19 in asymptomatic individuals with SARS-CoV-2 infection. Methods: We did a multicentre, randomized, double-blind, placebo-controlled trial, in asymptomatic unvaccinated adults (≥18 years of age) with confirmed SARS-CoV-2 infection within 5 days between April 28 and December 27, 2021. Participants were randomly assigned (1:1:1) to receive a blinded subcutaneous infusion of 10 mL with 1 g or 2 g of C19-IG20%, or an equivalent volume of saline as placebo. The primary endpoint was the proportion of participants who remained asymptomatic through day 14 after infusion. Secondary endpoints included the proportion of individuals who required oxygen supplementation, any medically attended visit, hospitalisation, or ICU, and viral load reduction and viral clearance in nasopharyngeal swabs. Safety was assessed as the proportion of patients with adverse events. The trial was terminated early due to a lack of potential benefit in the target population in a planned interim analysis conducted in December 2021. ClinicalTrials.gov registry: NCT04847141. Findings: 461 individuals (mean age 39.6 years [SD 12.8]) were randomized and received the intervention within a mean of 3.1 (SD 1.27) days from a positive SARS-CoV-2 test. In the prespecified modified intention-to-treat analysis that included only participants who received a subcutaneous infusion, the primary outcome occurred in 59.9% (91/152) of participants receiving 1 g C19-IG20%, 64.7% (99/153) receiving 2 g, and 63.5% (99/156) receiving placebo (difference in proportions 1 g C19-IG20% vs. placebo, −3.6%; 95% CI -14.6% to 7.3%, p = 0.53; 2 g C19-IG20% vs placebo, 1.1%; −9.6% to 11.9%, p = 0.85). None of the secondary clinical efficacy endpoints or virological endpoints were significantly different between study groups. Adverse event rate was similar between groups, and no severe or life-threatening adverse events related to investigational product infusion were reported. Interpretation: Our findings suggested that administration of subcutaneous human hyperimmune immunoglobulin C19-IG20% to asymptomatic individuals with SARS-CoV-2 infection was safe but did not prevent development of symptomatic COVID-19. Funding: Grifols

Rivaroxaban with or without aspirin in stable cardiovascular disease

BACKGROUND: We evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. METHODS: In this double-blind trial, we randomly assigned 27,395 participants with stable atherosclerotic vascular disease to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). The primary outcome was a composite of cardiovascular death, stroke, or myocardial infarction. The study was stopped for superiority of the rivaroxaban-plus-aspirin group after a mean follow-up of 23 months. RESULTS: The primary outcome occurred in fewer patients in the rivaroxaban-plus-aspirin group than in the aspirin-alone group (379 patients [4.1%] vs. 496 patients [5.4%]; hazard ratio, 0.76; 95% confidence interval [CI], 0.66 to 0.86; P<0.001; z=−4.126), but major bleeding events occurred in more patients in the rivaroxaban-plus-aspirin group (288 patients [3.1%] vs. 170 patients [1.9%]; hazard ratio, 1.70; 95% CI, 1.40 to 2.05; P<0.001). There was no significant difference in intracranial or fatal bleeding between these two groups. There were 313 deaths (3.4%) in the rivaroxaban-plus-aspirin group as compared with 378 (4.1%) in the aspirin-alone group (hazard ratio, 0.82; 95% CI, 0.71 to 0.96; P=0.01; threshold P value for significance, 0.0025). The primary outcome did not occur in significantly fewer patients in the rivaroxaban-alone group than in the aspirin-alone group, but major bleeding events occurred in more patients in the rivaroxaban-alone group. CONCLUSIONS: Among patients with stable atherosclerotic vascular disease, those assigned to rivaroxaban (2.5 mg twice daily) plus aspirin had better cardiovascular outcomes and more major bleeding events than those assigned to aspirin alone. Rivaroxaban (5 mg twice daily) alone did not result in better cardiovascular outcomes than aspirin alone and resulted in more major bleeding events