376 research outputs found
Application of Geometric Polarization to Invariance Properties in Bistatic Scattering
Bistatic polarimetric radars provide target properties which just one monostatic system can not reveal. Moreover, augmentation of monostatic systems through the provision of bistatic receive-only stations can be a cheap way to increase the amount of remote sensing data. However, bistatic scattering needs to be investigated in order to properly define target properties such as symmetries and invariance, especially regarding choices of polarization basis. In this paper we discuss how the geometric theory of polarization, in which the geometry of the Poincaré sphere is directly related to 3-D geometry of space rather than the 2-D geometry of the wavefront plane, can be used to reduce the ambiguities in the interpretation of data. We also show how in the coherent case a complex scalar invariant can be determined irrespective of the basis combinations
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Lake surface temperature [in “State of the Climate in 2017”]
Observed lake surface water temperature anomalies
in 2017 are placed in the context of the recent
warming observed in global surface air temperature
by collating long-term in situ lake
surface temperature observations from some of the
world’s best-studied lakes and a satellite-derived
global lake surface water temperature dataset. The
period 1996–2015, 20 years for which satellite-derived
lake temperatures are available, is used as the base
period for all lake temperature anomaly calculations
Phenotypic expansion of DGKE-associated diseases.
Atypical hemolytic uremic syndrome (aHUS) is usually characterized by uncontrolled complement activation. The recent discovery of loss-of-function mutations in DGKE in patients with aHUS and normal complement levels challenged this observation. DGKE, encoding diacylglycerol kinase-ε, has not been implicated in the complement cascade but hypothetically leads to a prothrombotic state. The discovery of this novel mechanism has potential implications for the treatment of infants with aHUS, who are increasingly treated with complement blocking agents. In this study, we used homozygosity mapping and whole-exome sequencing to identify a novel truncating mutation in DGKE (p.K101X) in a consanguineous family with patients affected by thrombotic microangiopathy characterized by significant serum complement activation and consumption of the complement fraction C3. Aggressive plasma infusion therapy controlled systemic symptoms and prevented renal failure, suggesting that this treatment can significantly affect the natural history of this aggressive disease. Our study expands the clinical phenotypes associated with mutations in DGKE and challenges the benefits of complement blockade treatment in such patients. Mechanistic studies of DGKE and aHUS are, therefore, essential to the design of appropriate therapeutic strategies in patients with DGKE mutations
Localization of a gene for nonsyndromic renal hypodysplasia to chromosome 1p32-33.
Nonsyndromic defects in the urinary tract are the most common cause of end-stage renal failure in children and account for a significant proportion of adult nephropathy. The genetic basis of these disorders is not fully understood. We studied seven multiplex kindreds ascertained via an index case with a nonsyndromic solitary kidney or renal hypodysplasia. Systematic ultrasonographic screening revealed that many family members harbor malformations, such as solitary kidneys, hypodysplasia, or ureteric abnormalities (in a total of 29 affected individuals). A genomewide scan identified significant linkage to a 6.9-Mb segment on chromosome 1p32-33 under an autosomal dominant model with reduced penetrance (peak LOD score 3.5 at D1S2652 in the largest kindred). Altogether, three of the seven families showed positive LOD scores at this interval, demonstrating heterogeneity of the trait (peak HLOD 3.9, with 45% of families linked). The chromosome 1p32-33 interval contains 52 transcription units, and at least 23 of these are expressed at stage E12.5 in the murine ureteric bud and/or metanephric mesenchyme. These data show that autosomal dominant nonsyndromic renal hypodysplasia and associated urinary tract malformations are genetically heterogeneous and identify a locus for this common cause of human kidney failure
Mutations in DSTYK and dominant urinary tract malformations.
ABSTRACT
Introduction
Congenital abnormalities of the kidney of the urinary tract are the most common cause of pediatric kidney failure. These disorders are highly heterogeneous, and their etiology is poorly understood.
Methods
We performed genome-wide linkage analysis and whole-exome sequencing in a family with autosomal dominant congenital abnormalities of the kidney of the urinary tract (7 affected family members). We also performed sequence analysis in 311 unrelated patients, as well as histologic and functional studies.
Results
Linkage analysis identified five regions of the genome that were shared among all affected family members. Exome sequencing identified a single rare deleterious variant within these linkage intervals, a heterozygous splice-site mutation in dual serine/threonine and tyrosine protein kinase (DSTYK). This variant, which resulted in aberrant gene product splicing, was present in all affected family members. Additional independent DSTYK mutations, including nonsense and splice-site mutations, were detected among 7/311 unrelated patients. DSTYK is highly expressed in the maturing epithelia of all major organs, localizing to cell membranes. Knockdown in zebrafish resulted in multi-organ developmental defects, resembling loss of fibroblast growth factor (FGF) signaling. Consistent with this finding, DSTYK colocalizes with FGF receptors in the ureteric bud and metanephric mesenchyme. Finally, DSTYK knockdown in human embryonic kidney cells inhibited FGF-stimulated ERK-phosphorylation, the principal signal downstream of receptor tyrosine kinases.
Conclusions
We detected DSTYK mutations in 2.2% of patients with congenital abnormalities of the kidney and urinary tract whom we studied, suggesting that DSTYK is a major determinant of human urinary tract development, downstream of FGF signaling
Lake surface water temperature [in “State of the Climate in 2019”]
Regional Climates is one chapter from the State of the Climate in 2019 annual report. Compiled
by NOAA’s National Centers for Environmental Information, State of the Climate in 2019 is
based on contributions from scientists from around the world. It provides a detailed update on
global climate indicators, notable weather events, and other data collected by environmental
monitoring stations and instruments located on land, water, ice, and in space.Universidad de Costa Rica/[805-B9-454]/UCR/Costa RicaUCR::VicerrectorĂa de InvestigaciĂłn::Unidades de InvestigaciĂłn::Ciencias Básicas::Centro de Investigaciones GeofĂsicas (CIGEFI
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