Decorous lower bounds for minimum linear arrangement

Minimum Linear Arrangement is a classical basic combinatorial optimization problem from the 1960s, which turns out to be extremely challenging in practice. In particular, for most of its benchmark instances, even the order of magnitude of the optimal solution value is unknown, as testified by the surveys on the problem that contain tables in which the best known solution value often has one more digit than the best known lower bound value. In this paper, we propose a linear-programming based approach to compute lower bounds on the optimum. This allows us, for the first time, to show that the best known solutions are indeed not far from optimal for most of the benchmark instances

Phase Diagram of the 1D Kondo Lattice Model

We determine the boundary of the fully polarized ferromagnetic ground state in the one dimensional Kondo lattice model at partial conduction electron band filling by using a newly developed infinite size DMRG method which conserves the total spin quantum number. The obtained paramagnetic to ferromagnetic phase boundary is below $J \approx 3.5$ for the whole range of band filling. By this we solve the controversy in the phase diagram over the extent of the ferromagnetic region close to half filling.Comment: 6 pages, 4 EPS figures. Presented at MOS9

Coherence length in superconductors from weak to strong coupling

We study the evolution of the superconducting coherence length $\xi_0$ from weak to strong coupling, both within a s-wave and a d-wave lattice model. We show that the identification of $\xi_0$ with the Cooper-pair size $\xi_{pair}$ in the weak-coupling regime is meaningful only for a fully-gapped (e.g., s-wave) superconductor. Instead in the d-wave superconductor, where $\xi_{pair}$ diverges, we show that $\xi_0$ is properly defined as the characteristic length scale for the correlation function of the modulus of the superconducting order parameter. The strong-coupling regime is quite intriguing, since the interplay between particle-particle and particle-hole channel is no more negligible. In the case of s-wave pairing, which allows for an analytical treatment, we show that $\xi_0$ is of order of the lattice spacing at finite densities. In the diluted regime $\xi_0$ diverges, recovering the behavior of the coherence length of a weakly interacting effective bosonic system. Similar results are expected to hold for d-wave superconductors.Comment: 11 pages, 5 figures. Two appendices and new references adde

Charge and spin inhomogeneity as a key to the physics of the high Tc cuprates

We present a coherent scenario for the physics of cuprate superconductors, which is based on a charge-driven inhomogeneity, i.e. the ``stripe phase''. We show that spin and charge critical fluctuations near the stripe instability of strongly correlated electron systems provide an effective interaction between the quasiparticles, which is strongly momentum, frequency, temperature and doping dependent. This accounts for the various phenomena occurring in the overdoped, optimally and underdoped regimes both for the normal and the superconductive phase.Comment: 6 pages, 1 enclosed figure, proceedings of LT2

Quantum Ising model in a transverse random field: A density-matrix renormalization group analysis

The spin-1/2 quantum Ising chain in a transverse random magnetic field is studied by means of the density-matrix renormalization group. The system evolves from an ordered to a paramagnetic state as the amplitude of the random field is increased. The dependence of the magnetization on a uniform magnetic field in the z direction and the spontaneous magnetization as a function of the amplitude of the transverse random magnetic field are determined. The behavior of the spin-spin correlation function both above and at criticality is studied. The scaling laws for magnetization and correlation functions are tested against previous numerical and renormalization-group results.Comment: 5 pages with 7 figures inside them, proper format of authors' names use

Effective medium theory for superconducting layers: A systematic analysis including space correlation effects

We investigate the effects of mesoscopic inhomogeneities on the metal-superconductor transition occurring in several two-dimensional electron systems. Specifically, as a model of systems with mesoscopic inhomogeneities, we consider a random-resistor network, which we solve both with an exact numerical approach and by the effective medium theory. We find that the width of the transition in these two-dimensional superconductors is mainly ruled by disorder rather than by fluctuations. We also find that "tail" features in resistivity curves of interfaces between LaAlO3 or LaTiO3 and SrTiO3 can arise from a bimodal distribution of mesoscopic local Tc's and/or substantial space correlations between the mesoscopic domains.Comment: 12 pages, 10 figure

Railway Rolling Stock Planning: Robustness Against Large Disruptions

In this paper we describe a two-stage optimization model for determining robust rolling stock circulations for passenger trains. Here robustness means that the rolling stock circulations can better deal with large disruptions of the railway system. The two-stage optimization model is formulated as a large mixed-integer linear programming (MILP) model. We first use Benders decomposition to determine optimal solutions for the LP-relaxation of this model. Then we use the cuts that were generated by the Benders decomposition for computing heuristic robust solutions for the two-stage optimization model. We call our method Benders heuristic. We evaluate our approach on the real-life rolling stock-planning problem of Netherlands Railways, the main operator of passenger trains in the Netherlands. The computational results show that, thanks to Benders decomposition, the LP-relaxation of the two-stage optimization problem can be solved in a short time for a representative number of disruption scenarios. In addition, they demonstrate that the robust rolling stoc

Tumor cellular and microenvironmental cues controlling invadopodia formation

During the metastatic progression, invading cells might achieve degradation and subsequent invasion into the extracellular matrix (ECM) and the underlying vasculature using invadopodia, F-actin-based and force-supporting protrusive membrane structures, operating focalized proteolysis. Their formation is a dynamic process requiring the combined and synergistic activity of ECM-modifying proteins with cellular receptors, and the interplay with factors from the tumor microenvironment (TME). Significant advances have been made in understanding how invadopodia are assembled and how they progress in degradative protrusions, as well as their disassembly, and the cooperation between cellular signals and ECM conditions governing invadopodia formation and activity, holding promise to translation into the identification of molecular targets for therapeutic interventions. These findings have revealed the existence of biochemical and mechanical interactions not only between the actin cores of invadopodia and specific intracellular structures, including the cell nucleus, the microtubular network, and vesicular trafficking players, but also with elements of the TME, such as stromal cells, ECM components, mechanical forces, and metabolic conditions. These interactions reflect the complexity and intricate regulation of invadopodia and suggest that many aspects of their formation and function remain to be determined. In this review, we will provide a brief description of invadopodia and tackle the most recent findings on their regulation by cellular signaling as well as by inputs from the TME. The identification and interplay between these inputs will offer a deeper mechanistic understanding of cell invasion during the metastatic process and will help the development of more effective therapeutic strategies