Étude typologique des stèles égyptiennes tardives (essai d'analyse qualitative et quantitative)

Notre thèse de doctorat en égyptologie a pour principal objet de créer une typologie des stèles privées, funéraires et votives, datées de la Troisième Période Intermédiaire à l'époque romaine, afin de caractériser ces stèles selon leur provenance et d'en effectuer une analyse qualitative et quantitative. Cette approche nous permet de certifier la provenance de certaines stèles, tout en déterminant les différents types attestés pour chaque origine, et d'offrir un outil typologique favorisant l'identification d'autres stèles, dont l'origine est restée inconnue à ce jour. La datation a également été prise en compte afin de définir les périodes durant lesquelles tel ou tel élément iconographique de la stèle égyptienne tardive, en esquissant les grandes tendances et en mettant en lumière leurs nombreuses spécificités. La réalisation de l'ensemble de ce travail a nécessité la création d'une base de données dénommée "Stèles", qui répond à l'un de nos souhaits essentiels : celui de créer un outil accessible à tous. La base Stèles servira de socle à d'autres études, facilitant la vérification et le recoupement d'informations, permettant de ne pas omettre de documents référencés, et offrant, enfin, un gain de temps précieux dans la recherche . Dans cette optique, la consultation de la base Stèles sera mise gratuitement en ligne sur Internet, via le serveur du laboratoire CNRS Halma-IpelThe main objective of our doctoral thesis in Egyptology was to create a typology of the private, funerary and votive stelae dating from the Third Intermediate Period of the Roman era, in order to characterize them according to their origin and to analyse them quantitatively and qualitatively. This approach enabled us to ascertain the origin of certain stelae, as well as determine the different recognized types for each origin, and to provide a typological tool facilitating the identification of other stelae whose origin had hitherto been unknown. Datins was also taken into account in defining the periods during which an iconographic or textual element was used, and that led us to redraw the chronological development of the late Egyptian stelae, by outlining their principal characteristics and highlighting their numerous specificities. In order to achieve this work, we had to create a data base named "Stèles", which fulfils one of our essential aims : to create a tool accessible to all. The "Stèles" can serve as a base for other studies, facilitating the checking and cross-checking of information, without having to leave out referenced documents, and, in the end, to provide a precious gain in research time. With this aim in mind, the consulation of the "Stèles" base will be freely available online on Internet, via the Halma-Ipel CNRS laboratory serverLILLE3-BU (590092101) / SudocLILLE3-IRHIS Bib. G. Lefèbvre (590092218) / SudocSudocFranceF

Maternal Exposure to Domestic Hair Cosmetics and Occupational Endocrine Disruptors Is Associated with a Higher Risk of Hypospadias in the Offspring

International audiencePregnant women are exposed to various chemical products at home and at work. Some of these products contain endocrine-disrupting chemicals (EDCs) such as cosmetics, pesticides, industrial chemicals, heavy metals, plastics or medications that could alter sexual differentiation and increase the risk of hypospadias. We evaluated maternal occupational and household exposures that could constitute risk factors for hypospadias. From 2011 to 2014, we enrolled 57 full-term newborns with hypospadias and three randomly selected controls per case (162 control newborns), matched for gestational age, from 11 maternity units in Picardy, France. Neonatal and parental data were collected at birth (personal characteristics, maternal lifestyle, and medical history). Maternal occupational exposure was assessed by a job-exposure matrix for EDCs from a job history questionnaire completed by mothers. Odds ratios (OR) and 95% confidence intervals (CI) were calculated with univariate and multivariable logistic regression, and adjusted for relevant covariates. Multivariate analysis showed a strong association between hypospadias and potential maternal occupational exposure to EDCs and maternal household use of hair cosmetics (OR 6.1, 95% CI: 1.1-34.9; OR: 9.6, 95% CI: 1.4-66.1, respectively). Our results suggest that maternal occupational exposure to EDCs is a risk factor for hypospadias and suggests a possible influence of household use of hair cosmetics during early pregnancy on the incidence of hypospadias in the offspring. A larger study with more accurate exposure assessment should evaluate the impact of EDCs in hair cosmetics on the incidence of hypospadias

Response to Elwood, M. et al., Comment on: Maternal Exposure to Domestic Hair Cosmetics and Occupational Endocrine Disruptors Is Associated with a Higher Risk of Hypospadias in the Offspring. Int. J. Environ. Res. Public Health 2017, 14, 27

Dear Editor, Thank you for inviting us to reply to a “Comment” paper to our published paper “Maternal Exposure to Domestic Hair Cosmetics and Occupational Endocrine Disruptors Is Associated with a Higher Risk of Hypospadias in the Offspring” (Authors: Elodie Haraux, Karine Braun, Philippe Buisson, Erwan Stéphan-Blanchard, Jannick Ricard, Camille Devauchelle, Bernard Boudailliez, Pierre Tourneux, Richard Gouron, Karen Chardon).[...

Erratum: Haraux, E., et al. Maternal Exposure to Domestic Hair Cosmetics and Occupational Endocrine Disruptors Is Associated with a Higher Risk of Hypospadias in the Offspring. Int. J. Environ. Res. Public Health 2017, 14, 27

Due to an error during production, some data presented in Table 1 in the Experimental section of the published paper [1] were incorrect.[...

Clinicopathologic monitoring of the skin and oral mucosa of the first human face allograft: Report on the first eight months

Background. The first human face allograft was performed in France on November 27, 2005. We report herein the clinicopathologic findings from the skin and oral mucosa of this allograft during the first eight months. Methods. Sequential biopsies were taken from the facial skin (n=3), oral mucosa (n=20), and sentinel skin graft (n=1.1) from day 3 to day 220 postgraft and examined (immuno) histologically, using a pathological score previously proposed for evaluation of rejection in composite tissue (hand) transplantation. Results. The patient developed clinically rejection episodes at day 20 and during the eighth month postgraft, manifesting with redness and edema of the facial skin, oral mucosa, and sentinel graft skin. Pathologically, changes suggestive of rejection grades 0, I, II, and III were seen in 1, 1, 1, and 0 biopsies of facial skin, 7, 2, 1, and I biopsies of sentinel skin graft and 3, 5, 8, and 4 biopsies of oral mucosa, respectively. Pathological changes were generally more severe in the oral mucosa than in facial and sentinel graft skin (mean scores 1.85, 0.64, and 1, respectively). Conclusions. As it happens with other composite tissue allografts, close clinicopathologic monitoring of the skin (and oral mucosa) seems to be the most reliable way to detect rejection in the setting of human facial tissue allotransplantation. Apart from these rejection episodes, the skin and mucosa maintained a normal microscopic structure, paralleling functional recovery

L’alliance thérapeutique est associée à l’adhésion au traitement chez les enfants atteints d’arthrite juvénile idiopathique

International audienc

Therapeutic alliance is associated to treatment adherence in children with juvenile idiopathic arthritis

International audienceTherapeutic alliance (TA) is the agreement between caregiver and patient during the care process. Therapeutic adherence is a major issue for the management of Juvenile Idiopathic Arthritis (JIA) requiring child's strong ability to follow treatments. The aim of this study was to evaluate the relationship between TA and adherence in patients with JIA.Methods: Observational, cross-sectional, multicenter study. Children, with JIA, aged 8-16, were included. Children, parents and physicians completed the Helping Alliance Questionnaire (HAQ-CP) for assessing TA. Adherence was measured using the Child/Parent Adherence Report Questionnaire (CARQ & PARQ). Demographic data, disease characteristics, current treatments and social environment were collected. The univariate relationship between TA and adherence, was studied by Pearson correlation coefficient. The multivariate analysis used a multiple linear regression model.Results: A total of 119 patients were included: 68.9% girls, mean age (SD) 12.4 (2.9) years, disease duration 73.1 (48.2) months. JIA was in remission (52%), in low activity (32%) and active (16%). TA scores were high (≥80/100) for children, parents and physicians. HAQCP was highly correlated with CARQ (r=0.31; P<0.001) PARQ (r=0.37; P<0.001). In univariate analysis, disease activity (P<0.05), place of residence (P<0.01) and family status (P<0.01) were associated with child's TA. In multivariate analysis, only the place of residence (P<0.001) and the family status (P<0.05) remained associated with TA.Conclusion: TA strongly influences therapeutic adherence and therefore may be important for treatment effectiveness