Comparative genomics of the major parasitic worms

Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report a broad comparative study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritized new potential drug targets and compounds for testing. This comparative genomics resource provides a much-needed boost for the research community to understand and combat parasitic worms

Usine des Brasseries et Glacières d'Algérie Hussein-Dey Alger

Courtot Ch. Usine des Brasseries et Glacières d'Algérie Hussein-Dey Alger. In: Chantiers. Revue illustrée de la construction en Afrique du Nord, N°33, 1959. Bâtiments industriels. p. 27

Usine UNIC (Maison-Carrée Alger)

Courtot Ch. Usine UNIC (Maison-Carrée Alger). In: Chantiers. Revue illustrée de la construction en Afrique du Nord, N°33, 1959. Bâtiments industriels. pp. 28-29

Manuel de physique électricité statique et voltaique, thermo-électricité, magnétisme, électro-magnétisme, induction etc

par J. C*** et Ch. Courtot; ouvrage illustré de 130 figures intercalées dans le texte, gravées par MM. Yves et Barre

Will the Effects of Sea-Level Rise Create Ecological Traps for Pacific Island Seabirds?

<div><p>More than 18 million seabirds nest on 58 Pacific islands protected within vast U.S. Marine National Monuments (1.9 million km²). However, most of these seabird colonies are on low-elevation islands and sea-level rise (SLR) and accompanying high-water perturbations are predicted to escalate with climate change. To understand how SLR may impact protected islands and insular biodiversity, we modeled inundation and wave-driven flooding of a globally important seabird rookery in the subtropical Pacific. We acquired new high-resolution Digital Elevation Models (DEMs) and used the Delft3D wave model and ArcGIS to model wave heights and inundation for a range of SLR scenarios (+0.5, +1.0, +1.5, and +2.0 m) at Midway Atoll. Next, we classified vegetation to delineate habitat exposure to inundation and identified how breeding phenology, colony synchrony, and life history traits affect species-specific sensitivity. We identified 3 of 13 species as highly vulnerable to SLR in the Hawaiian Islands and quantified their atoll-wide distribution (Laysan albatross, <i>Phoebastria immutabilis</i>; black-footed albatross, <i>P</i>. <i>nigripes</i>; and Bonin petrel, <i>Pterodroma hypoleuca</i>). Our models of wave-driven flooding forecast nest losses up to 10% greater than passive inundation models at +1.0 m SLR. At projections of + 2.0 m SLR, approximately 60% of albatross and 44% of Bonin petrel nests were overwashed displacing more than 616,400 breeding albatrosses and petrels. Habitat loss due to passive SLR may decrease the carrying capacity of some islands to support seabird colonies, while sudden high-water events directly reduce survival and reproduction. This is the first study to simulate wave-driven flooding and the combined impacts of SLR, groundwater rise, and storm waves on seabird colonies. Our results highlight the need for early climate change planning and restoration of higher elevation seabird refugia to prevent low-lying protected islands from becoming ecological traps in the face of rising sea levels.</p></div