The use of genes for performance enhancement: doping or therapy?

Recent biotechnological advances have permitted the manipulation of genetic sequences to treat several diseases in a process called gene therapy. However, the advance of gene therapy has opened the door to the possibility of using genetic manipulation (GM) to enhance athletic performance. In such ‘gene doping’, exogenous genetic sequences are inserted into a specific tissue, altering cellular gene activity or leading to the expression of a protein product. The exogenous genes most likely to be utilized for gene doping include erythropoietin (EPO), vascular endothelial growth factor (VEGF), insulin-like growth factor type 1 (IGF-1), myostatin antagonists, and endorphin. However, many other genes could also be used, such as those involved in glucose metabolic pathways. Because gene doping would be very difficult to detect, it is inherently very attractive for those involved in sports who are prepared to cheat. Moreover, the field of gene therapy is constantly and rapidly progressing, and this is likely to generate many new possibilities for gene doping. Thus, as part of the general fight against all forms of doping, it will be necessary to develop and continually improve means of detecting exogenous gene sequences (or their products) in athletes. Nevertheless, some bioethicists have argued for a liberal approach to gene doping

Gerenciamento rural: novo enfoque: eficiência.

Metodologia do sistema gerencial; Cálculo da viabilidade financeira da implementação de tecnologias; Cálculo do custo/benefício da produção agropecuária; Cálculo do custo/benefício da pastagem cultivada (consorciação azevém, cornichão e trevo-branco).bitstream/item/110555/1/GERENCIAMENTO-RURAL.pd

Biofábrica: produção em escala piloto de clones de dendê: Embrapa instalará em Manaus, laboratório para melhoramento genético, produção e avaliação de clones de dendê.

bitstream/item/44260/1/Revista-Agroenergia-2-1413.pd

Saharan dust electrification perceived by a triangle of atmospheric electricity stations in Southern Portugal

Atmospheric Electric Potential Gradient (PG) measurements were carried out in three sites forming a triangular array in Southern Portugal. The campaign was performed during the summer, characterized by Saharan dust outbreaks; 16th-17th July 2014 dust event is considered. Short time-scale oscillations of the PG at two of the stations and a mid time-scale suppression of the PG in the three stations are found. Results are interpreted as evidencing long-range dust electrification; attributed to the air-Earth electrical current creating a bipolar charge distribution inside of the dust layer. The relevance of using arrays of sensors, instead of single sited, is highlighted

Sistema e custo de produção de gado de corte no Estado do Rio Grande do Sul - região da Campanha.

Programa da pecuária de corte no Rio Grande so Sul. Descrição do sistema de produção de gado de corte da região da campanha - Rio Grande do Sul. Benfeitoria, máquinas e equipamentos. Composição do rebanho e desempenho zootécnico. Controle sanitário. Mão de obra. Sistema gerancial e contábil. Resultados econômicos do sistema modal de cria, recria e engorda. Estrutua de custos. Receita e sua composição. Custo de produção e margens econômicas. Custos de produção variando a capacidade de suporte dos pastos e a taxa de natalidade. Considerações finais.bitstream/item/79815/1/COT95.pdfCNPGC

Sistema e custo de produção de gado de corte no Estado do Rio Grande do Sul - região da Campanha.

Programa da pecuária de corte no Rio Grande so Sul. Descrição do sistema de produção de gado de corte da região da campanha - Rio Grande do Sul. Benfeitoria, máquinas e equipamentos. Composição do rebanho e desempenho zootécnico. Controle sanitário. Mão de obra. Sistema gerancial e contábil. Resultados econômicos do sistema modal de cria, recria e engorda. Estrutua de custos. Receita e sua composição. Custo de produção e margens econômicas. Custos de produção variando a capacidade de suporte dos pastos e a taxa de natalidade. Considerações finais.bitstream/item/104666/1/sistema-e-custo-de-producao-de-gado-de-corte.pdfCNPGC

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components

Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum. In the present study, we elucidate the serum and complement susceptibility of B. valaisiana, a genospecies with the potential to cause Lyme disease in Europe as well as in Asia. Among the investigated isolates, growth of ZWU3 Ny3 was not affected while growth of VS116 and Bv9 was strongly inhibited in the presence of 50% human serum. Analyzing complement activation, complement components C3, C4 and C6 were deposited on the surface of isolates VS116 and Bv9, and similarly the membrane attack complex was formed on their surface. In contrast, no surface-deposited components and no aberrations in cell morphology were detected for serum-resistant ZWU3 Ny3. While further investigating the protective role of bound complement regulators in mediating complement resistance, we discovered that none of the B. valaisiana isolates analyzed bound complement regulators Factor H, Factor H-like protein 1, C4b binding protein or C1 esterase inhibitor. In addition, B. valaisiana also lacked intrinsic proteolytic activity to degrade complement components C3, C3b, C4, C4b, and C5. Taken together, these findings suggest that certain B. valaisiana isolates differ in their capability to resist complement-mediating killing by human serum. The molecular mechanism utilized by B. valaisiana to inhibit bacteriolysis appears not to involve binding of the key host complement regulators of the alternative, classical, and lectin pathways as already known for serum-resistant Lyme disease or relapsing fever borreliae

Avaliação de consumo alimentar residual de touros Hereford e Braford.

O trabalho tem por objetivo avaliar o CAR e o ganho de peso residual (GPR), comparando touros das raças Hereford e Braford, provenientes da Prova de Avaliação a Campo do CPPSul.Editora técnica Claudia Cristina Gulias Gomes

Avaliação genômica para características ligadas à eficiência alimentar em bovinos da raça Angus.

Seleção Genômica; Provas de Eficiência Alimentar; Características Avaliadas; Consumo Alimentar Residual; Consumo Matéria Prima; Como Interpretar as Avaliações Genômicas Diferença Esperada na Progênie; Acurária (AC); Percentil (%); ResultadosPublicado também como impresso. ODS 2, ODS 12