An appeal to the global health community for a tripartite innovation: an ‘‘Essential Diagnostics List,’’ ‘‘Health in All Policies,’’ and ‘‘See-Through 21st Century Science and Ethics"

Diagnostics spanning a wide range of new biotechnologies, including proteomics, metabolomics, and nanotechnology, are emerging as companion tests to innovative medicines. In this Opinion, we present the rationale for promulgating an ‘‘Essential Diagnostics List.’’ Additionally, we explain the ways in which adopting a vision for ‘‘Health in All Policies’’ could link essential diagnostics with robust and timely societal outcomes such as sustainable development, human rights, gender parity, and alleviation of poverty. We do so in three ways. First, we propose the need for a new, ‘‘see through’’ taxonomy for knowledge-based innovation as we transition from the material industries (e.g., textiles, plastic, cement, glass) dominant in the 20th century to the anticipated knowledge industry of the 21st century. If knowledge is the currency of the present century, then it is sensible to adopt an approach that thoroughly examines scientific knowledge, starting with the production aims, methods, quality, distribution, access, and the ends it purports to serve. Second, we explain that this knowledge trajectory focus on innovation is crucial and applicable across all sectors, including public, private, or public–private partnerships, as it underscores the fact that scientific knowledge is a co-product of technology, human values, and social systems. By making the value systems embedded in scientific design and knowledge co-production transparent, we all stand to benefit from sustainable and transparent science. Third, we appeal to the global health community to consider the necessary qualities of good governance for 21st century organizations that will embark on developing essential diagnostics. These have importance not only for science and knowledge based innovation, but also for the ways in which we can build open, healthy, and peaceful civil societies today and for future generations

Molecular Characterization, Population Structure Analysis, and Association Mapping of Turkish Parsley Genotypes Using iPBS Markers

Parsley (Petroselinum crispum Mill.) is a vegetable that has many benefits for human health, and its cultivation is increasing. In order to carry out breeding studies in parsley, genotypes should be characterized in terms of some characteristics. In this study, some phytochemical properties of 18 different parsley genotypes were revealed, and their genetic diversity was determined with the iPBS (Inter Primary Binding Site) marker system. In the study, the polymorphism rate was 31.9%, the mean PIC (Polymorphic Information Content) was 0.17, and the similarity coefficients were between 0.87 and 0.99. The number of subpopulations was determined as two, and 10 markers were detected at expression levels of 19–33% related to phytochemical properties. The results of this study show that there is a phytochemical and genetic variation in parsley. Parsley genotypes with certain phytochemical properties and genetic structures can be used more effectively in breeding programs

The Effect of Grafting on Morphological, Physiological and Molecular Changes Induced by Drought Stress in Cucumber

Drought is one of the most important abiotic stress factors affecting crop yields and qualities worldwide. One drought-sensitive plant is the cucumber, which has a high transpiration rate. Grafting is recognized as a promising approach to increasing tolerance to abiotic stresses in cucumber. In this study, it is aimed to determine the rootstock that will prevent negative changes in some growth, physiological and genetic parameters of cucumber under drought stress and to determine the mechanism of the system. In drought stress conditions, leaf number values were found to be 6 on average in non-grafted plants and between 6–13.16 in grafted plants. Average leaf fresh weight values (7.56–9.84 g) obtained from grafted plants were higher than non-grafted plants (5.7 g). Leaf chlorophyll content (SPAD) values were found to be between 24.43 in non-grafted plants and 37.83–55.36 in grafted plants under stress conditions. Malondialdehyde (MDA) concentration values also decreased from 5.66 to 3.23–4.36 in grafted plants. It was determined that the genomic template stability (GTS) rate was 64.1% in the non-grafted treatment group. DNA polymorphisms detected by ISSR (inter simple sequence repeat) can be used as a biomarker system for the detection of genotoxic effects of abiotic stresses, such as drought. These findings suggest that grafting with drought-resistant rootstocks may improve drought tolerance in drought-sensitive cucumber genotypes

Energy Saving In Continuous Annealing Line Using Heating Optimization

Energy consumption of Iron and Steel Industry sector in Turkey has the highest share in final energy consumption. In the globalized world, day by day, worsening of the conditions of competition and negative environmental pressures, more efficient energy usage is come to the forefront. Growing industries can survive by providing efficient energy consumption and effective energy follow-up. The failure of businesses is become inevitable with ineffective and inefficient usage of energy resources used in the production. Energy savings in the continuous annealing line which is the subject of this article is an important issue and it is based on many parameters. Measuring strip's temperature is so important to continuous annealing line control in the annealing automation system. Increasing or decreasing the oven temperature provides the process control with the adjustment of the heater which is specific heating capacity in these furnaces. Each strip annealing temperature is different which depends on the strip quality. Also strip thickness, strip width and the line speed are the other factors of the oven temperature conditions. It needs to realize the production of an optimal quality ranking to increase the line speed. This improves the production level and because of the oven temperature changes in the order that causes the reduction of costs due to energy savings, optimized production is achieved. Finding the most suitable production sequence is modeled by fuzzy goal programming functions used the above parameters were investigate

An evaluation of sustainable competitive advantega in terms of core competences and dynamic capabilities

Bu çalışmanın amacı küreselleşen piyasalarda işletmelerin farklılaşma ve ayırt edici özellikler kazanmasında kilit rol oynayan temel yeteneklerin ve dinamik kabiliyetlerin sürdürülebilir rekabet avantajı elde etmeye etkisinin araştırılmasıdır. Çalışmanın yöntemi, temel yetenekler, dinamik kabiliyetler ve sürdürülebilir rekabet konularında daha önceki dönemlerde yapılmış olan çalışmalar üzerinden literatür taraması şeklinde belirlenmiştir. Ayrıca temel yeteneklerin ve dinamik kabiliyetlerin sürdürülebilir rekabet avantajına etkisi üzerine bir model oluşturulmuştur. Bir işletmenin rekabet avantajı oluşturabilmesi için gerekli olan temel yetenekleri kesin olarak belirlemesi ve eşsiz dinamik kabiliyetler oluşturmasına ihtiyaç duyulacağı sonucuna varılmıştır. Temel yetenekler ve dinamik kabiliyetler kavramlarının daha derinlemesine anlaşılmasına, bir işletmenin bunları oluştururken ve geliştirirken dikkat etmesi gereken noktaların altının çizilmesine ve bu konunun rekabet avantajı açısından öneminin pekiştirilmesine katkı sağlanacağı düşünülmektedir.This study's objective is to examine the influence of core competence and dynamic capabilities which play a key role in a firm's differentiation and gaining distinct characteristics in globalized market on achieving sustainable competitive advantages. The method used in this study is to review the literature regarding core competence, dynamic capabilities and sustainable competitive advantages. Additionaly a model which defines the influence of core competence and dynamic capabilities on achieving sustainable competitive advantages was developed. This study concludes that a company needs to firmly identify required core competence and to establish unique dynamic capabilities in order to develop a competitive advantage. This study proposes to contribute to a deeper understanding for concept of core competence and dynamic capabilities, to underline what needs to be pay attention as they were created and developed and to reinforce the important this concept interns of competitive advantage