Analisis de la eficiencia tecnica de la unidad de VPN UNAN-LEON utilizando funcion de produccion stochastic frontier, 2007-2008

This article measures and analyses the workers technical efficiency in the production virus unit of the UNAN-Leon, during period 2007-2008. For our study we use sectional cruces data take on a normal half Distribution and the measure methodology known as Stochastic Frontier Production Function (Coelli, 1995). The results shown, with technology known as production of polyhedrons nuclear virus (PNV), that the workers were underused in a 58 % during period of study. This indicator makes emphasis on the organizing levels workers to face the technology applied, training and education levels. From this results, is advising to reflect about the combine of technology applied with the worker rational use, to refer the organization, technical training by up productive level and up technical efficiency. In addition, I suggest the necessary for a worker reengineering or worker specializing of the unit PNV, focuses it in satisfies dose Production demand that involve the strengthening of business with farmers. Aggressive strategy business will be suggested

Turbulence and Cavity Recirculation in Air-Water Skimming Flows on a Stepped Spillway

Current expertise in air-water turbulent flows on stepped chutes is limited mostly to laboratory experiments at low to moderate Reynolds numbers on chutes with flat horizontal steps. In this study, highly turbulent air-water flows skimming down a large-size stepped chute were investigated with a 1V:2.5H slope. For some experiments, the cavity recirculation was controlled using triangular vanes, or longitudinal ribs, to enhance the interactions between the skimming flow and cavity recirculating region. New experiments were performed with seven configurations. The results demonstrated the strong influence of the vanes on the cavity recirculation patterns and on the air-water flow properties. An increase in flow resistance was observed consistently with maximum rate of energy dissipation achieved with vanes placed in a zigzag pattern

The seesaw mechanism at TeV scale in the 3-3-1 model with right-handed neutrinos

We implement the seesaw mechanism in the 3-3-1 model with right-handed neutrinos. This is accomplished by the introduction of a scalar sextet into the model and the spontaneous violation of the lepton number. We identify the Majoron as a singlet under $SU_L(2)\otimes U_Y(1)$ symmetry, which makes it safe under the current bounds imposed by electroweak data. The main result of this work is that the seesaw mechanism works already at TeV scale with the outcome that the right-handed neutrino masses lie in the electroweak scale, in the range from MeV to tens of GeV. This window provides a great opportunity to test their appearance at current detectors, though when we contrast our results with some previous analysis concerning detection sensitivity at LHC, we conclude that further work is needed in order to validate this search.Comment: about 13 pages, no figure

Self-Aeration and Turbulence in a Stepped Channel: Influence of Cavity Surface Roughness

The strong interactions between free-surface flows and atmospheric surroundings may lead to substantial air-water mixing with void fractions ranging from zero in clear-water to 100%. In this study, the air-water flow properties were studied in a large stepped water channel operating at large Reynolds numbers. Interactions between free-surface and cavity recirculation were systematically investigated in the skimming flow regime. Some surface roughness was introduced on the cavity walls and identical experiments were performed with several configurations. Basic results demonstrated some influence of step surface roughness on the flow properties leading to some counter-intuitive finding. The presence of cavity roughness was associated with higher flow velocities and comparatively lower turbulence levels. Distributions of bubble/droplet chords spanned over several orders of magnitude without significant influence of the cavity roughness. The distributions of turbulence levels and bubble count rates showed some correlation and highlighted strong interactions between entrained particles (bubbles, drops) and the flow turbulence

MiniBooNE Results and Neutrino Schemes with 2 sterile Neutrinos: Possible Mass Orderings and Observables related to Neutrino Masses

The MiniBooNE and LSND experiments are compatible with each other when two sterile neutrinos are added to the three active ones. In this case there are eight possible mass orderings. In two of them both sterile neutrinos are heavier than the three active ones. In the next two scenarios both sterile neutrinos are lighter than the three active ones. The remaining four scenarios have one sterile neutrino heavier and another lighter than the three active ones. We analyze all scenarios with respect to their predictions for mass-related observables. These are the sum of neutrino masses as constrained by cosmological observations, the kinematic mass parameter as measurable in the KATRIN experiment, and the effective mass governing neutrinoless double beta decay. It is investigated how these non-oscillation probes can distinguish between the eight scenarios. Six of the eight possible mass orderings predict positive signals in the KATRIN and future neutrinoless double beta decay experiments. We also remark on scenarios with three sterile neutrinos. In addition we make some comments on the possibility of using decays of high energy astrophysical neutrinos to discriminate between the mass orderings in presence of two sterile neutrinos.Comment: 33 pages, 8 figures. Comments added, to appear in JHE

Nuclear parton distributions at next to leading order

We perform a next to leading order QCD global analysis of nuclear deep inelastic scattering and Drell-Yan data using the convolution approach to parameterize nuclear parton densities. We find both a significant improvement in the agreement with data compared to previous extractions, and substantial differences in the scale dependence of nuclear effects compared to leading order analyses.Comment: 9 pages, 10 figure

Sharp Trace Hardy-Sobolev-Maz'ya Inequalities and the Fractional Laplacian

In this work we establish trace Hardy and trace Hardy-Sobolev-Maz'ya inequalities with best Hardy constants, for domains satisfying suitable geometric assumptions such as mean convexity or convexity. We then use them to produce fractional Hardy-Sobolev-Maz'ya inequalities with best Hardy constants for various fractional Laplacians. In the case where the domain is the half space our results cover the full range of the exponent $s \in (0,1)$ of the fractional Laplacians. We answer in particular an open problem raised by Frank and Seiringer \cite{FS}.Comment: 42 page

Antimicrobial and antibiofilm capacity of chitosan nanoparticles against wild type strain of pseudomonas sp. Isolated from milk of cows diagnosed with bovine mastitis

Indexación; Scopus.Bovine mastitis (BM) is the most prevalent bacterial infection in the livestock sector, affecting the dairy industry greatly. The prevention and treatment of this disease is mainly made via antibiotics, but the increasing antimicrobial resistance of pathogens has affected the efficiency of conventional drugs. Pseudomonas sp. is one of the pathogens involved in this infection. The therapeutic rate of cure for this environmental mastitis-causing pathogen is practically zero, regardless of treatment. Biofilm formation has been one of the main virulence mechanisms of Pseudomonas hence presenting resistance to antibiotic therapy. We have manufactured chitosan nanoparticles (NQo) with tripolyphosphate (TPP) using ionotropic gelation. These NQo were confronted against a Pseudomonas sp. strain isolated from milk samples of cows diagnosed with BM, to evaluate their antimicrobial and antibiofilm capacity. The NQo showed great antibacterial effect in the minimum inhibitory concentrations (MIC), minimum bactericidal concentration (MBC) and disk diffusion assays. Using sub lethal concentrations, NQo were tested for inhibition of biofilm formation. The results show that the nanoparticles exhibited biofilm inhibition and were capable of eradicate pre-existing mature biofilm. These findings indicate that the NQo could act as a potential alternative to antibiotic treatment of BM. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.https://www.mdpi.com/2079-6382/9/9/55

Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics

Indexación ScopusErythropoiesis is the most robust cellular differentiation and proliferation system, with a production of ∼2 × 1011 cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) generate erythroid progenitors, which proliferate and mature into erythrocytes. During erythropoiesis, mitochondria are reprogrammed to drive the differentiation process before finally being eliminated by mitophagy. In erythropoiesis, mitochondrial dynamics (MtDy) are expected to be a key regulatory point that has not been described previously. We described that a specific MtDy pattern occurs in human erythropoiesis from EPO-induced human CD34+ cells, characterized predominantly by mitochondrial fusion at early stages followed by fission at late stages. The fusion protein MFN1 and the fission protein FIS1 are shown to play a key role in the progression of erythropoiesis. Fragmentation of the mitochondrial web by the overexpression of FIS1 (gain of fission) resulted in both the inhibition of hemoglobin biosynthesis and the arrest of erythroid differentiation, keeping cells in immature differentiation stages. These cells showed specific mitochondrial features as compared with control cells, such as an increase in round and large mitochondrial morphology, low mitochondrial membrane potential, a drop in the expression of the respiratory complexes II and IV and increased ROS. Interestingly, treatment with the mitochondrial permeability transition pore (mPTP) inhibitor, cyclosporin A, rescued mitochondrial morphology, hemoglobin biosynthesis and erythropoiesis. Studies presented in this work reveal MtDy as a hot spot in the control of erythroid differentiation, which might signal downstream for metabolic reprogramming through regulation of the mPTP. © Copyright © 2020 Gonzalez-Ibanez, Ruiz, Jensen, Echeverria, Romero, Stiles, Shirihai and Elorza.https://www.frontiersin.org/articles/10.3389/fcell.2020.592035/ful