Adaption of the Students’ motivation towards science learning (SMTSL) questionnaire into Albanian language

This study focused at adapting the students’ motivation towards science learning questionnaire (SMTSL) into the Albanian version, originally developed by Tuan, Chin, and Shieh (2005), into a different cultural context, focusing on chemistry learning subject. 366 students from natural sciences high school enrolled in 10th, 11th and 12th grade were randomly selected to be part of the study. The present study applied and confirmed the questionnaire with 35 items and 6 subscales, same as in orginal version. The questionnaires’ reliability (α.86) was acceptable for the Kosovar context and study’s findings were in compliance with the results of the previous studies. SMTSL’s factioral structure was confirmed using explanatory factor analysis. Results showed that the questionnaire is valid and six-subscales motivation construct can be applied in this study’s cultural setting and sample with reference to learning chemistry

Coaching teachers to integrate technology: The effects of technology integration on student performance and critical thinking

This article presents the results of a mixed-methods study that investigated effects of technology integration practices of teachers in a 5th grade students’ scores and critical thinking in a public school, and introduced coaching for technology integration as a strategy to train in-service teachers for technology integration. The purpose of the research was to analyse how technology integration in science course effects on student's performance and critical thinking. The participants were 132 students and four teachers in elementary public school. The study used an experimental research design by having a control and research group (68 were in the two teachers’ classrooms that were using technology without coaching intervention and 64 were in the other two teachers’ classrooms, coached by the researchers to integrate available technologies). The data were collected through pre-test and post-test, classroom observation and semi-structured interview with teachers. The results showed that coached teachers integrated technology more frequently, purposefully and diversely. Additionally, the results indicated that technology integration positively affected student performance and student critical thinking behaviours in the 5th grade science unit

IMPACT OF CARBAZOLE P-LACTAM DERIVATIVES ON PARAOXONASE-1 ACTIVITY

Paraoxonase 1 (PON1) is an antioxidant enzyme associated with high-density lipoproteins (HDL). PON1 has the ability to inhibit lipid peroxides and to hydrolyze a wide variety of substrates such as esters, thioesters, phosphotriesterases, carbonates, lactones and thio lactones. We hypothesized that whether paraoxonase hydrolyses some carbazole P-lactam compounds or not. For this purpose, human serum paraoxonase (hPON1) was purified from human serum blood via two step procedure by using ammonium sulphate precipitation and sepharose-4B-L-tyrosinel-napthylamine-chromatograpy. The in vitro effects of P-lactam compounds on paraoxonase 1 (PON1) were investigated using paraoxon substrate. The results showed that carbazole P-lactam derivatives positively modulated paraoxonase enzyme activity. Among the compounds, 3g and 3h on PON enzyme were found to be the most powerful activators

Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials

PMID = 3101517

Novel carvacrol based new oxypropanolamine derivatives: Design, synthesis, characterization, biological evaluation, and molecular docking studies

Carvacrol, as a natural product used for many years in the treatment of various diseases, therefore it was chosen as the starting compound for this study. Novel carvacrol based new oxypropanolamine derivatives were synthesized and characterized by spectroscopic methods. All new compounds were tested as metabolic enzyme inhibitory agents. Their clinical usage of carvacrol has been established as diuretics, antiepileptics, and anti-glaucoma factors, in the management of gastric, duodenal ulcers, mountain sickness, osteoporosis, idiopathic intracranial hypertension, or neurological disorders. The in vitro anti-hyperglycemic screening results showed that the compound 3d exhibits the maximum inhibitory effect against alpha-glycosidase enzyme (IC50: 904.10 nM). In addition, the compounds 3d (IC50: 29.74 nM and 23.64 nM) and 3e (IC50: 31.28 nM and 26.11 nM) were found to have a significant response to inhibit carbonic anhydrase I, and II isoenzymes (hCA I and II), respectively. The novel carvacrol based oxypropanolamine compounds were effective inhibitors of the hCA I and II isozymes, and acetylcholinesterase with Ki values in the range of 27.18-44.84 nM for hCA I, 25.62-38.71 nM for hCA II, and 99.83-146.25 nM for AChE, respectively. (C) 2019 Elsevier B.V. All rights reserved.

Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials

Five oxypropanol amine derivatives that four of them are novel have been synthesized with high yields and practical methods. in vitro antibacterial susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus strains to synthesized substances were evaluated with agar well-diffusion method by comparison with commercially available drugs. Most of the bacteria were multidrug resistant. It was concluded that these compounds are much more effective than reference drugs. These eugenol bearing oxypropanolamine derivatives were also effective inhibitors against α-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) enzymes with Ki values in the range of 0.80 ± 0.24–3.52 ± 1.01 µM for hCA I, 1.08 ± 0.15–3.64 ± 0.92 µM for hCA II, 5.18 ± 0.84–12.46 ± 2.08 µM for α-glycosidase, and 11.33 ± 2.83–32.81 ± 9.73 µM for AChE, respectivel