507 research outputs found
LIBERALIZAĂĂO COMERCIAL E DEMANDA POR TRABALHO QUALIFICADO NO BRASIL
This paper aims to understand the dynamic of the relative demand for skilled labor in Brazilian industry, during the last decade. Thus, presenting evidences that relative demand for skill increased overall in the period, it seeks to explain this movement, at least in part. For this, we test the hypothesis of skill biased technological changes in an environment of economic opening. The results indicate that a greater share of imported intermediate goods in factories, signaled by the reduction in the tariffs charged on these goods, explains the shift in relative demand for skilled labor, throughout an increasing in the relative productivity between skilled and unskilled workers. This points out to the fact that the hypothesis of skill biased technological changes explains, at least in part, the shift in the relative demand for skilled labor.
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Essays on Asset Pricing and Downside Risk
This dissertation contributes to the recent and diverse literature on the relation between downside risk and asset prices. In chapter one, we use a famous quote among professional investors, "focus on the downside, and the upside will take care of itself", to motivate a representative consumer-investor who only cares about the downside. The consumption-based asset pricing model that emerges from this idea explains the main existing puzzles found within the asset pricing literature. These include the equity premium and the risk-free rate puzzles, the countercyclicality of the equity premium and the procyclicality of the risk-free rate. The model is parsimonious, requiring only three preference-related parameters: the time discount factor, the elasticity of intertemporal substitution, and the downside risk aversion. When we use the model to understand the relation between returns and consumption in the US, we find that the fitted parameter values are consistent with what is expected from the micro foundations. In chapter two, we show that the model proposed in chapter one can also explain the financial puzzles in other developed countries. This is an important step in the empirical validation of the model. The estimated parameters are robust across highly capitalized countries and qualitatively close to the ones obtained for the US. Moreover, the risk measure under the quantile utility model can better justify the differences in risk premia across countries when compared to the risk measure under the expected utility model. In chapter three, we evaluate the effect of margin requirements on asset prices, an additional channel for the relation between downside risk and prices. We provide evidences of the existence of an aggregate margin-related premium in the economy. In particular, we show that (i) a margin-related factor is able to predict future excess returns of the S&P 500 and (ii) stocks with high betas on the margin-related factor pay on average higher returns compared those with low margin betas. These result are important not only to understand asset prices, but also the unconventional polices implemented by the Fed during the great recession of 2007-2010. Although data on margin requirements for the S&P 500 futures are publicly available, it is in general very hard to obtain information on margins for other assets. Given that, we also propose a nonparametric model for estimating margins as a function of the asset's value at risk. This is theoretically justifiable and has good empirical results
Optimizing quantum-enhanced Bayesian multiparameter estimation in noisy apparata
Achieving quantum-enhanced performances when measuring unknown quantities
requires developing suitable methodologies for practical scenarios, that
include noise and the availability of a limited amount of resources. Here, we
report on the optimization of quantum-enhanced Bayesian multiparameter
estimation in a scenario where a subset of the parameters describes unavoidable
noise processes in an experimental photonic sensor. We explore how the
optimization of the estimation changes depending on which parameters are either
of interest or are treated as nuisance ones. Our results show that optimizing
the multiparameter approach in noisy apparata represents a significant tool to
fully exploit the potential of practical sensors operating beyond the standard
quantum limit for broad resources range
Non-asymptotic Heisenberg scaling: experimental metrology for a wide resources range
Adopting quantum resources for parameter estimation discloses the possibility
to realize quantum sensors operating at a sensitivity beyond the standard
quantum limit. Such approach promises to reach the fundamental Heisenberg
scaling as a function of the employed resources in the estimation process.
Although previous experiments demonstrated precision scaling approaching
Heisenberg-limited performances, reaching such regime for a wide range of
remains hard to accomplish. Here, we show a method which suitably allocates the
available resources reaching Heisenberg scaling without any prior information
on the parameter. We demonstrate experimentally such an advantage in measuring
a rotation angle. We quantitatively verify Heisenberg scaling for a
considerable range of by using single-photon states with high-order orbital
angular momentum, achieving an error reduction greater than dB below the
standard quantum limit. Such results can be applied to different scenarios,
opening the way to the optimization of resources in quantum sensing
Securities Lending and Short Selling
Purpose â The aim of this study is to offer the current view on the subject, placing emphasis on studies that use Brazilian data and that could motivate new research.
Design/methodology/approach âA bibliographic review of related studies and a secondary database.
Findings â The contribution is to introduce this topic for the academic community in Brazil. We also present the main descriptive information for this market and its economic and policy implications.
Originality/value â We contribute to the literature by summarizing the main works in the field, focusing on the Brazilian market, which has very detailed data and great potential for further studies
Transport Through Andreev Bound States in a Graphene Quantum Dot
Andreev reflection-where an electron in a normal metal backscatters off a
superconductor into a hole-forms the basis of low energy transport through
superconducting junctions. Andreev reflection in confined regions gives rise to
discrete Andreev bound states (ABS), which can carry a supercurrent and have
recently been proposed as the basis of qubits [1-3]. Although signatures of
Andreev reflection and bound states in conductance have been widely reported
[4], it has been difficult to directly probe individual ABS. Here, we report
transport measurements of sharp, gate-tunable ABS formed in a
superconductor-quantum dot (QD)-normal system, which incorporates graphene. The
QD exists in the graphene under the superconducting contact, due to a
work-function mismatch [5, 6]. The ABS form when the discrete QD levels are
proximity coupled to the superconducting contact. Due to the low density of
states of graphene and the sensitivity of the QD levels to an applied gate
voltage, the ABS spectra are narrow, can be tuned to zero energy via gate
voltage, and show a striking pattern in transport measurements.Comment: 25 Pages, included SO
Cytochrome 450 1B1 (CYP1B1) polymorphisms associated with response to docetaxel in Castration-Resistant Prostate Cancer (CRPC) patients
BACKGROUND:
The selection of patients according to key genetic characteristics may help to tailor chemotherapy and optimize the treatment in Castration-Resistant Prostate Cancer (CRPC) patients. Functional polymorphisms within the cytochrome P450 1B1 (CYP1B1) gene have been associated with alterations in enzymatic expression and activity and may change sensitivity to the widely used docetaxel regimen.
METHODS:
CYP1B1 genotyping was performed on blood samples of 60 CRPC patients treated with docetaxel, using TaqMan probes-based assays. Association between CYP1B1-142C>G (leading to the 48ArgGly transition), 4326C>G (432LeuVal), and 4390A>G (453AsnSer) polymorphisms and treatment response, progression-free-survival (PFS) and overall-survival (OS) was estimated using Pearson Ï2 test, Kaplan-Meier curves and Log-rank test.
RESULTS:
Patients carrying the CYP1B1-432ValVal genotype experienced a significantly lower response-rate (P = 0.014), shorter progression-free-survival (P = 0.032) and overall-survival (P < 0.001). Multivariate analyses and correction for multiple comparisons confirmed its prognostic significance for OS. No significant associations were found among other polymorphisms and both response and clinical outcome.
CONCLUSIONS:
CYP1B1-4326C>G (432LeuVal) polymorphism emerged as possible predictive marker of response and clinical outcome to docetaxel in CRPC patients and may represent a potential new tool for treatment optimization. Larger prospective trials are warranted to validate these findings, which might be applied to the future practice of CRPC treatment
Filtering multiphoton emission from state-of the-art cavity quantum electrodynamics
© 2018 Optical Society of America. Engineering multiphoton states is an outstanding challenge with applications in multiple fields such as quantum metrology, quantum lithography, or even biological sensing. State-of-the-art methods to obtain them rely on post-selection, multi-level systems, or Rydberg atomic ensembles. Recently, it was shown that a strongly driven two-level system interacting with a detuned cavity mode can be engineered to continuously emit n-photon states. In the present work, we show that spectral filtering of its emission relaxes considerably the requirements on the system parameters even to the more accessible bad-cavity situation, opening up the possibility of implementing this protocol in a much wider landscape of different platforms. This improvement is based on a key observation: in the imperfect case where only a certain fraction of emission is composed of n-photon states, these have a well-defined energy separated from the rest of the signal, which allows one to reveal and purify multiphoton emission just by frequency filtering. We demonstrate these results by obtaining analytical expressions for the relevant figures of merit of multiphoton emission, such as the n-photon coupling rate between cavity and emitter, the fraction of light emitted as n-photon states, and n-photon emission rates. This allows us to make a systematic study of such figures of merit as a function of the system parameters and demonstrate the viability of the protocol in several relevant types of cavity quantum electrodynamics setups, where we take into account the impact of their respective experimental limitations.Published versio
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