О сущности языковой компетенции

В статье даётся характеристика сущностных сторон языковой компетенции как био и социального и интеллектуального феномена.У статті подається характеристика сутнісних сторін мовної компетенції як біо та соціального та інтелектуального феномену.The characteristics of essential aspects of language competency as bio- and social and intellectual phenomenon is given in the article

Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence

We conducted a 1000 Genomes-imputed genome-wide association study (GWAS) meta-analysis for nicotine dependence, defined by the Fagerstrom Test for Nicotine Dependence in 17 074 ever smokers from five European-ancestry samples. We followed up novel variants in 7469 ever smokers from five independent European-ancestry samples. We identified genome-wide significant association in the alpha-4 nicotinic receptor subunit (CHRNA4) gene on chromosome 20q13: lowest P = 8.0 x 10(-9) across all the samples for rs2273500-C (frequency = 0.15; odds ratio = 1.12 and 95% confidence interval = 1.08-1.17 for severe vs mild dependence). rs2273500-C, a splice site acceptor variant resulting in an alternate CHRNA4 transcript predicted to be targeted for nonsense-mediated decay, was associated with decreased CHRNA4 expression in physiologically normal human brains (lowest P = 7.3 x 10(-4)). Importantly, rs2273500-C was associated with increased lung cancer risk (N = 28 998, odds ratio = 1.06 and 95% confidence interval = 1.00-1.12), likely through its effect on smoking, as rs2273500-C was no longer associated with lung cancer after adjustment for smoking. Using criteria for smoking behavior that encompass more than the single 'cigarettes per day' item, we identified a common CHRNA4 variant with important regulatory properties that contributes to nicotine dependence and smoking-related consequences.Peer reviewe

Manufacturing Energy Bandwidth Studies: Chemical, Peroleum Refining, Pulp and Paer, and Iron and Steel Sectors

Energy efficiency underlies American manufacturing competitiveness. Improvements in efficiency yield energy cost savings on site, and can have positive spin-off effects through the supply chain. An evaluation of the technical potential within an industrial subsector requires an understanding of the current average (baseline) energy utilization, the current improvement potential if state-of-the-art technologies are deployed, and future energy savings expected if next generation technologies potentials are realized. These bandwidths between baseline and improved energy efficiency potentials provide a consistent methodology to evaluate, aggregate and communicate energy savings potentials within industry. In this paper, we review bandwidth studies of four of the most energy intensive manufacturing sectors in the United States. The Chemical, Petroleum Refining, Iron and Steel, and Pulp and Paper Energy Bandwidth Studies serve as generalized guides for energy technology advancement opportunities. These studies identify energy intensity and consumption for key manufacturing processes and the sector as a whole. Potential energy savings opportunities are identified by quantifying four measures of energy consumption for each process area: current average (year 2010), state of the art, practical minimum, and thermodynamic minimum. These measures enable prediction of current savings opportunities and future savings opportunities, with supporting detail on opportunity areas. The resulting reports provide useful guides for determining which manufacturing sectors and processes are the most energy-intensive and offer the greatest energy savings opportunities from technology advances

Energy considerations associated with increased adoption of seawater desalination in the United States

Due in part to increased water demand and uncertainty around the availability of existing freshwater resources, there is interest in expanding the use of seawater desalination in the U.S. In order for greater adoption to occur, existing barriers need to be mitigated. One of these barriers is the energy consumption of seawater desalination. This paper reviews the existing energy requirements for membrane and thermal-based seawater desalination systems to produce potable water. Through literature review, it identifies the commercially-available option with the lowest energy intensity and the thermodynamic minimum energy requirement for each unit operation of the system. The paper then estimates the energy requirements to expand seawater desalination capacity to meet the potable water needs of water-stressed regions in the U.S. The results show that supplying 10% of the potable water demand for these regions located within 250 miles of a coastline using the lowest energy-intensity seawater desalination system commercially available would require <0.1% of 2018 U.S. electricity consumption. This increases to approximately 0.5% if all public water for these same regions is supplied via desalinated seawater. These estimates of the energy implications of broader adoption provide an initial comparison to current U.S. electricity consumption

The mind’s eye: a photographic method for understanding meaning in people’s lives.

Although research relying on self-report inventories has built an increased appreciation of the importance of meaning in life, such research has strayed somewhat from the original promise of meaning in life research, which was to shed light on the individual experience of meaning. Some research has focused on understanding people’s sources of meaning. However, previous methods have relied on verbal ways of assessing sources of meaning in life. In recognition of the fact that not Everyone has highly developed verbal skills – and that even those who do can find it hard to articulate what life means – we offer a new method for understanding individuals’ experiences with meaning in life. In this article, we describe the use of photography to elicit information about people’s sources of meaning and provide inductive qualitative analysis of a pilot study using this method. Photography holds great potential as a new method for seeing meaning through another’s eyes.http://dx.doi.org/10.1080/17439760.2013.830760http://www.tandfonline.com/doi/pdf/10.1080/17439760.2013.83076

Energy considerations associated with increased adoption of seawater desalination in the United States

Due in part to increased water demand and uncertainty around the availability of existing freshwater resources, there is interest in expanding the use of seawater desalination in the U.S. In order for greater adoption to occur, existing barriers need to be mitigated. One of these barriers is the energy consumption of seawater desalination. This paper reviews the existing energy requirements for membrane and thermal-based seawater desalination systems to produce potable water. Through literature review, it identifies the commercially-available option with the lowest energy intensity and the thermodynamic minimum energy requirement for each unit operation of the system. The paper then estimates the energy requirements to expand seawater desalination capacity to meet the potable water needs of water-stressed regions in the U.S. The results show that supplying 10% of the potable water demand for these regions located within 250 miles of a coastline using the lowest energy-intensity seawater desalination system commercially available would require <0.1% of 2018 U.S. electricity consumption. This increases to approximately 0.5% if all public water for these same regions is supplied via desalinated seawater. These estimates of the energy implications of broader adoption provide an initial comparison to current U.S. electricity consumption