Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

. 34 Año 11 (2015) enero-mayo. Señales de humo

- Editorial por José Luis Perea González. - Experiencias en San Luis Potosí por Mayán Cervantes Leandro. - Tita, Mi Maestra por Amalia Attolini Lecón. - Beatriz Braniff. Marzo 26, 2014 por Déborah Oliveros Braniff. - El catálogo de sitios arqueológicos de Sonora y Beatriz Braniff por Cesár Armando Quijada López. - Beatriz Braniff, la pochteca que conquistó el noroeste por Ana María Álvarez Palma. - Entre la gran chichimeca y el gran noroeste: la presencia Braniff por Elisa Villalpando Canchola. - Tita Braniff: un personaje mexicano y una figura internacional por R.B Brown. - El acervo de Braniff en el archivo técnico por José Luis Ramírez Ramírez. - Publicaciones de Braniff en el Centro INAH Sonora por Guadalupe Piña Ortiz. - Homenaje a Tita Braniff por Pedro Francisco Sánchez Nava

Sputum Detection of Predisposing Genetic Mutations in Women with Pulmonary Nontuberculous Mycobacterial Disease

© 2018, The Author(s). Nontuberculous mycobacterial lung disease (NTM), including Mycobacterium avium complex (MAC), is a growing health problem in North America and worldwide. Little is known about the molecular alterations occurring in the tissue microenvironment during NTM pathogenesis. Utilizing next generation sequencing, we sequenced sputum and matched lymphocyte DNA in 15 MAC patients for a panel of 19 genes known to harbor cancer susceptibility associated mutations. Thirteen of 15 NTM subjects had a diagnosis of breast cancer (BCa) before or after NTM infection. Thirty three percent (4/12) of these NTM-BCa cases exhibited at least 3 somatic mutations in sputa compared to matched lymphocytes. Twenty four somatic mutations were detected with at least one mutation in ATM, ERBB2, BARD1, BRCA1, BRCA2, AR, TP53, PALB2, CASP8, BRIP1, NBN and TGFB1 genes. All four NTM-BCa patients harboring somatic mutations also exhibited 15 germ line BRCA1 and BRCA2 mutations. The two NTM subjects without BCa exhibited twenty somatic mutations spanning BRCA1, BRCA1, BARD1, BRIP1, CHEK2, ERBB2, TP53, ATM, PALB2, TGFB1 and 3 germ line mutations in BRCA1 and BRCA2 genes. A single copy loss of STK11 and AR gene was noted in NTM-BCa subjects. Periodic screening of sputa may aid to develop risk assessment biomarkers for neoplastic diseases in NTM patients