Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies

<p><b>Background and Purpose:</b> Glycine Antagonist in Neuroprotection (GAIN) International and GAIN Americas trials were prospectively designed, randomized, placebo-controlled trials of gavestinel, a glycine-site antagonist and putative neuroprotectant drug administered within 6 hours of suspected ischemic or hemorrhagic stroke. Both trials reported that gavestinel was ineffective in ischemic stroke. This analysis reports the results in those with primary intracerebral hemorrhage.</p> <p><b>Methods:</b> The primary hypothesis was that gavestinel treatment did not alter outcome, measured at 3 months by the Barthel Index (BI), from acute intracerebral hemorrhage, based on pooled results from both trials. The BI scores were divided into 3 groups: 95 to 100 (independent), 60 to 90 (assisted independence), and 0 to 55 (dependent) or dead.</p> <p><b>Results:</b> In total, 3450 patients were randomized in GAIN International (N=1804) and GAIN Americas (N=1646). Of these, 571 were ultimately identified to have spontaneous intracerebral hematoma on baseline head computerized tomography scan. The difference in distribution of trichotomized BI scores at 3 months between gavestinel and placebo was not statistically significant (P=0.09). Serious adverse events were reported at similar rates in the 2 treatment groups.</p> <p><b>Conclusions:</b> These observations from the combined GAIN International and GAIN Americas trials suggest that gavestinel is not of substantial benefit or harm to patients with primary intracerebral hemorrhage. These findings are similar to results previously reported in patients with ischemic stroke.</p&gt

Duality between Electric and Magnetic Black Holes

A number of attempts have recently been made to extend the conjectured $S$ duality of Yang Mills theory to gravity. Central to these speculations has been the belief that electrically and magnetically charged black holes, the solitons of quantum gravity, have identical quantum properties. This is not obvious, because although duality is a symmetry of the classical equations of motion, it changes the sign of the Maxwell action. Nevertheless, we show that the chemical potential and charge projection that one has to introduce for electric but not magnetic black holes exactly compensate for the difference in action in the semi-classical approximation. In particular, we show that the pair production of electric black holes is not a runaway process, as one might think if one just went by the action of the relevant instanton. We also comment on the definition of the entropy in cosmological situations, and show that we need to be more careful when defining the entropy than we are in an asymptotically-flat case.Comment: 23 pages, revtex, no figures. Major revision: two sections on the electric Ernst solution adde

Formulations of the 3+1 evolution equations in curvilinear coordinates

Following Brown, in this paper we give an overview of how to modify standard hyperbolic formulations of the 3+1 evolution equations of General Relativity in such a way that all auxiliary quantities are true tensors, thus allowing for these formulations to be used with curvilinear sets of coordinates such as spherical or cylindrical coordinates. After considering the general case for both the Nagy-Ortiz-Reula (NOR) and the Baumgarte-Shapiro-Shibata-Nakamura (BSSN) formulations, we specialize to the case of spherical symmetry and also discuss the issue of regularity at the origin. Finally, we show some numerical examples of the modified BSSN formulation at work in spherical symmetry.Comment: 19 pages, 12 figure

Residential sector end-use forecasting with EPRI-Reeps 2.1: Summary input assumptions and results

This paper describes current and projected future energy use by end-use and fuel for the U.S. residential sector, and assesses which end-uses are growing most rapidly over time. The inputs to this forecast are based on a multi-year data compilation effort funded by the U.S. Department of Energy. We use the Electric Power Research Institute`s (EPRI`s) REEPS model, as reconfigured to reflect the latest end-use technology data. Residential primary energy use is expected to grow 0.3% per year between 1995 and 2010, while electricity demand is projected to grow at about 0.7% per year over this period. The number of households is expected to grow at about 0.8% per year, which implies that the overall primary energy intensity per household of the residential sector is declining, and the electricity intensity per household is remaining roughly constant over the forecast period. These relatively low growth rates are dependent on the assumed growth rate for miscellaneous electricity, which is the single largest contributor to demand growth in many recent forecasts

Algebraic Topology Foundations of Supersymmetry and Symmetry Breaking in Quantum Field Theory and Quantum Gravity: A Review

A novel algebraic topology approach to supersymmetry (SUSY) and symmetry breaking in quantum field and quantum gravity theories is presented with a view to developing a wide range of physical applications. These include: controlled nuclear fusion and other nuclear reaction studies in quantum chromodynamics, nonlinear physics at high energy densities, dynamic Jahn-Teller effects, superfluidity, high temperature superconductors, multiple scattering by molecular systems, molecular or atomic paracrystal structures, nanomaterials, ferromagnetism in glassy materials, spin glasses, quantum phase transitions and supergravity. This approach requires a unified conceptual framework that utilizes extended symmetries and quantum groupoid, algebroid and functorial representations of non-Abelian higher dimensional structures pertinent to quantized spacetime topology and state space geometry of quantum operator algebras. Fourier transforms, generalized Fourier-Stieltjes transforms, and duality relations link, respectively, the quantum groups and quantum groupoids with their dual algebraic structures; quantum double constructions are also discussed in this context in relation to quasi-triangular, quasi-Hopf algebras, bialgebroids, Grassmann-Hopf algebras and higher dimensional algebra. On the one hand, this quantum algebraic approach is known to provide solutions to the quantum Yang-Baxter equation. On the other hand, our novel approach to extended quantum symmetries and their associated representations is shown to be relevant to locally covariant general relativity theories that are consistent with either nonlocal quantum field theories or local bosonic (spin) models with the extended quantum symmetry of entangled, 'string-net condensed' (ground) states

Raw genome sequence data for 13 isogenic Aspergillus fumigatus strains isolated over a 2 year period from a patient with chronic granulomatous disease

EB, AB and AW are supported by the Wellcome Trust Strategic Award (grant 097377), and the MRC Centre for Medical Mycology at the University of Aberdeen (grant MR/N006364/1). AB was also supported by the Biotechnology and Biological Research Council (BB/K017365/1) and the Medical Research Council (MR/M026663/1). The work in this paper is funded by a BBSRC EASTBIO grant (BB/M010996/1) awarded to AW. The funders had no role in study design, data interpretation, or the decision to submit the work for publication.Peer reviewedPublisher PD

Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague–Dawley rat

Peer reviewedPublisher PD

Pseudo SU(3) shell model: Normal parity bands in odd-mass nuclei

A pseudo shell SU(3) model description of normal parity bands in 159-Tb is presented. The Hamiltonian includes spherical Nilsson single-particle energies, the quadrupole-quadrupole and pairing interactions, as well as three rotor terms. A systematic parametrization is introduced, accompained by a detailed discussion of the effect each term in the Hamiltonian has on the energy spectrum. Yrast and excited band wavefunctions are analyzed together with their B(E2) values.Comment: 29 pages, 6 figure

Quasi-SU(3) truncation scheme for even-even sd-shell nuclei

The Quasi-SU(3) symmetry was uncovered in full pf and sdg shell-model calculations for both even-even and odd-even nuclei. It manifests itself through a dominance of single-particle and quadrupole-quadrupole terms in the Hamiltonian used to describe well-deformed nuclei. A practical consequence of the quasi-SU(3) symmetry is an efficient basis truncation scheme. In a recent work was shown that when this type of Hamiltonian is diagonalized in an SU(3) basis, only a few irreducible represntations (irreps) of SU(3) are needed to describe the Yrast band, the leading S = 0 irrep augmented with the leading S = 1 irreps in the proton and neutron subspaces. In the present article the quasi-SU(3) truncation scheme is used, in conjunction with a "realistic but schematic" Hamiltonian that includes the most important multipole terms, to describe the energy spectra and B(E2) transition strengths of 20-Ne, 22-Ne, 24-Mg and 28-Si. The effect of the size of the Hilbert space on both sets of observables is discussed, as well as the structure of the Yrast band and the importance of the various terms in the Hamiltonian.Comment: 30 pages, 8 figures. Submited to Nucl. Phys.