73 research outputs found
Human papillomavirus detection in paraffin-embedded colorectal cancer tissues
Human papillomavirus (HPV) has a well-recognized aetiological role in the development of cervical cancer and other anogenital tumours. Recently, an association between colorectal cancer and HPV infection has been suggested, although this is still controversial. This study aimed at detecting and characterizing HPV infection in 57 paired biopsies from colorectal cancers and adjacent intact tissues using a degenerate PCR approach. All amplified fragments were genotyped by means of sequencing. Overall, HPV prevalence was 12.3 %. In particular, 15.8% of tumour tissues and 8.8% of non-cancerous tissue samples were HPV DNA-positive. Of these samples, 85.7% were genotyped successfully, with 41.7% of sequences identifying four genotypes of the HR (high oncogenic risk) clade Group 1; the remaining 58.3% of HPVgenotyped specimens had an unclassified \u3b2-HPV. Examining additional cases and analysing whole genomes will help to outline the significance of these findings
Malignant peripheral nerve sheath tumors and spindle cell sarcomas: An immunohistochemical analysis of multiple markers
[No abstract available
Human pulmonary dirofilariasis, report of a new European case
We report a new European case of
pulmonary dirofilariasis occurring in an Italian patient.
The paper emphasizes the peculiar pathological
features of Pulmonary Dirofilariasis, that, on clinical and
radiological grounds, closely irriitates primary or
secondary neoplasms.
The disease characteristically presents itrelf as a
solitary subpleural coin-like lesion, histologically
corresponding to a well demarcatec,, roughly spherical
infarct, centered by a medium-sized thrombosed artery
whose lumen contains the parasite, i.e. a Dirofilaria
nematode
Hepatic tumor and tumor-like lesions in childhood
Tumors of the liver are rare in infancy and childhood. Some are peculiar to the pediatric age, e.g., hepatoblastoma, infantile hemangioendothelioma, mesenchymal hamartoma, embryonal rhabdomyosarcoma. This review is based upon personal experience with a series of 32 cases. On the basis of the histological features it is proposed that focal modular hyperplasia (FNH) and mesenchymal hamartoma be considered as tumor-like lesions rather than true neoplasms. A few benign epithelial lesions (FNH, adenoma) were associated with inborn error of metabolism. In half of the patients, hepatocellular carcinoma (HCC) developed in perinatally hepatitis B virus (HBV)-infected children. HCC developed in a noncirrhotic liver in a single patient, in whom HBV-DNA integration had occurre
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