CONHECIMENTO DE USUÁRIAS DE ANTICONCEPCIONAIS ORAIS ACERCA DE HÁBITOS E INTERAÇÕES MEDICAMENTOSAS EM UMA UNIDADE BÁSICA DE SAÚDE

Trata-se de um estudo exploratório com o objetivo de identificar o conhecimento de usuárias de pílula anticoncepcional oral acerca de hábitos e interações medicamentos que possam comprometer o efeito contraceptivo. Foram aplicados 21 questionários em usuárias atendidas na Unidade Básica de Saúde Vila Guaíra, na cidade de Curitiba. Dentre as usuárias 47,6% apresentam idade entre 25 e 35 anos, possui dois filhos, e 9,5% relatou não ingerir o medicamento corretamente todos os dias no mesmo horário, ingerindo o mesmo apenas quando lembra. Em relação ao conhecimento da associação com antibióticos, 52,3% não utiliza método de barreira quando está em tratamento com esse tipo de medicação. Concluiu-se que o enfermeiro, a partir do conhecimento inerente de sua formação e atuação profissional pode contribuir com a orientação e encaminhamento adequado para cada método contraceptivo

Vivendo em comunidade, envelhecendo de forma saudável

Introduction: It is remarkable the increase of the Brazilian elderly population. Advances in research and technology have contributed to increase life expectancy, reduce mortality and improve quality of life.Objectives: Elaborate the profile of the elderly participants of the research and identify the health impacts of the elderly due to their participation in activities at the Universidade Aberta à Pessoas Idosas (UnAPI).Method: Descriptive and exploratory quantitative-qualitative study. Inclusion criteria adopted: age > 60 years, having joined UnAPI for 6 months, being enrolled in the activities and having attended more than once. A questionnaire containing socio-demographic/socioeconomic data, health condition/comorbidities, and open-ended questions related to the change in health and lifestyle after participation in the activities of UnATI and the importance of the group in health and life were used.Results: The study showed female prevalence, mean age 73 years. Most of them reside in Vitória/ES, their own home, married, income from retirement, complete upper level and reported that after attending activities at UnATI noticed changes in their health, they began to feel more disposed to live, leave home, more joy. Regarding lifestyle, they said they had great influence, started to practice activities that stimulate memory, read more often, practice physical exercises, become more sociable, improve sleep, among other benefits.Conclusion: It was observed that the elderly notice changes, mainly in health, lifestyle, and relationships. Promoting better quality of life.Introducción: Es notable el aumento de la población anciana brasileña. Los avances en investigaciones y tecnologías han contribuido al aumento de la expectativa de vida, reducción de la mortalidad y mejora de la calidad de vida. Objetivos: Elaborar el perfil de los ancianos participantes e identificar los impactos en la salud del anciano y el estilo de vida derivado de la participación en actividades en la Universidade Abierta a Personas Ancianas (UnAPA).Método: Estudio descriptivo y exploratorio cuanti-cualitativo. Se utilizó un cuestionario que contenía datos sociodemográficos/socioeconómicos, condición de salud/comorbilidades, además de preguntas abiertas relacionadas al cambio en la salud y estilo de vida tras participación en las actividades de la UnAPA e importancia del grupo en la salud y en la vida del anciano.Resultados: El estudio apuntó prevalencia del sexo femenino, promedio de edad 73 años. La mayoría reside en Vitória/ES, casa propia, casados, renta proveniente de jubilación, nivel superior completo e informaron que después de frecuentar las actividades en la UnAPA notaron cambios en su salud, pasaron a sentir más disposición para vivir, salir de casa, más alegría. En cuanto al estilo de vida dijeron que tuvo influencia en la práctic de actividades que estimulan la memoria, pasaron a leer con más frecuencia, practicar ejercicios físicos, se volvieron más sociables, con mejora del sueño, entre otros beneficios.Conclusión: Se constató que los ancianos notan cambios em su salud, estilo de vida, y relaciones. Repercutiendo en una mejor calidad de vida.Introdução: É notável o aumento da população idosa brasileira em que avanços em pesquisas e tecnologias têm contribuído para o aumento da expectativa de vida, redução da mortalidade e melhoria da qualidade de vida. Objetivos: Elaborar o perfil dos idosos participantes e identificar os impactos na saúde do idoso e estilo de vida decorrente da participação em atividades na Universidade Aberta à Pessoas Idosas (UnAPI). Método: Estudo descritivo e exploratório quanti-qualitativo. Utilizou-se questionário contendo dados sociodemográficos / socioeconômicos, condição de saúde / comorbidades, além de perguntas abertas relacionadas à mudança na saúde e estilo de vida após participação nas atividades da UnAPI e importância do grupo na saúde e na vida do idoso. Resultados: Evidenciou prevalência do sexo feminino, casadas, média de 73 anos de idade, sendo expressivo a residência em Vitória/ES, em casa própria, com renda proveniente de aposentadoria e nível superior completo. Após frequentarem as atividades na UnATI, os participantes informaram mudanças em sua saúde, passando a sentir mais disposição para viver, sair de casa e ter mais alegria. Quanto ao estilo de vida relataram influência para a prática de atividades que estimulam a memória, passaram a ler com mais frequência, praticar exercícios físicos, tornaram-se mais sociáveis, com melhora do sono e outros benefícios. Conclusão: Constatou-se que os idosos notaram mudanças em sua saúde, estilo de vida, bem como nos relacionamentos, repercutindo beneficamente na qualidade de vida

PPAR-γ/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis

Polymicrobial sepsis induces organ failure and is accompanied by overwhelming inflammatory response and impairment of microbial killing. Peroxisome proliferator-activated receptor (PPAR)-γ is a nuclear receptor with pleiotropic effects on lipid metabolism, inflammation, and cell proliferation. The insulin-sensitizing drugs thiazolidinediones (TZDs) are specific PPAR-γ agonists. TZDs exert anti-inflammatory actions in different disease models, including polymicrobial sepsis. The TZD pioglitazone, which has been approved by the U.S. Food and Drug Administration, improves sepsis outcome; however, the molecular programs that mediate its effect have not been determined. In a murine model of sepsis, we now show that pioglitazone treatment improves microbial clearance and enhances neutrophil recruitment to the site of infection. We also observed reduced proinflammatory cytokine production and high IL-10 levels in pioglitazone-treated mice. These effects were associated with a decrease in STAT-1-dependent expression of MyD88 in vivo and in vitro. IL-10R blockage abolished PPAR-γ-mediated inhibition of MyD88 expression. These data demonstrate that the primary mechanism by which pioglitazone protects against polymicrobial sepsis is through the impairment of MyD88 responses. This appears to represent a novel regulatory program. In this regard, pioglitazone provides advantages as a therapeutic tool, because it improves different aspects of host defense during sepsis, ultimately enhancing survival

Tratamentos da Endometriose: Abordagens Medicamentosas, Cirúrgicas e Multidisciplinares

Endometriosis is a chronic gynecological condition characterized by the presence of tissue similar to the endometrium outside the uterine cavity. The treatment of endometriosis encompasses various approaches, including medicinal, surgical, and multidisciplinary interventions, aiming to alleviate symptoms and improve the patients' quality of life. In the medicinal realm, treatments aim to control the progression of the disease and alleviate associated pain. Hormones such as oral contraceptives, progestogens, and GnRH agonists are frequently prescribed to modulate hormone levels and inhibit the growth of ectopic endometrial tissue. These medications aim to relieve pain, regulate the menstrual cycle, and, in some cases, induce temporary remission of endometriosis. Surgical intervention becomes an option when medicinal therapy is ineffective or when severe complications arise. Laparoscopy is often utilized to remove ectopic endometrial tissue, ovarian cysts, and adhesions. In advanced cases, hysterectomy may be considered, especially for women who have completed their families and do not wish to have more children. The multidisciplinary approach is increasingly recognized as crucial in managing endometriosis. It involves collaboration among gynecologists, pain specialists, physiotherapists, psychologists, and other healthcare professionals. This holistic approach aims not only to address physical symptoms but also to tackle psychosocial aspects, enhancing the overall quality of life for patients. In summary, the treatment of endometriosis is complex and often involves a combination of medicinal, surgical, and multidisciplinary approaches. The choice of treatment depends on the severity of symptoms, the patient's reproductive desires, and other individual factors. Regular follow-ups with specialized healthcare professionals are essential for effective and personalized management of endometriosis. This review provides a comprehensive overview of the diverse treatment approaches for endometriosis, emphasizing the importance of considering not only the physical dimension but also the psychosocial aspects to optimize the quality of life for patients.A endometriose é uma condição ginecológica crônica caracterizada pela presença de tecido semelhante ao endométrio fora da cavidade uterina. O tratamento da endometriose abrange diversas abordagens, incluindo intervenções medicamentosas, cirúrgicas e multidisciplinares, buscando alívio dos sintomas e melhoria na qualidade de vida das pacientes. No âmbito medicamentoso, os tratamentos visam controlar a progressão da doença e reduzir a dor associada. Hormônios, como contraceptivos orais, progestágenos e agonistas de GnRH, são frequentemente prescritos para modular os níveis hormonais e inibir o crescimento do tecido endometrial ectópico. Esses medicamentos têm o objetivo de aliviar a dor, regular o ciclo menstrual e, em alguns casos, induzir a remissão temporária da endometriose. A abordagem cirúrgica torna-se uma opção quando a terapia medicamentosa não é eficaz ou quando há complicações graves. A laparoscopia é frequentemente utilizada para realizar a remoção do tecido endometrial ectópico, cistos ovarianos e aderências. Em casos mais avançados, a histerectomia pode ser considerada, especialmente em mulheres que já completaram sua família e não desejam mais filhos. A abordagem multidisciplinar é cada vez mais reconhecida como crucial no manejo da endometriose. Envolve a colaboração entre ginecologistas, especialistas em dor, fisioterapeutas, psicólogos e outros profissionais de saúde. Essa abordagem holística visa não apenas tratar os sintomas físicos, mas também abordar aspectos psicossociais, melhorando a qualidade de vida global das pacientes. Em resumo, o tratamento da endometriose é complexo e muitas vezes envolve uma combinação de abordagens medicamentosas, cirúrgicas e multidisciplinares. A escolha do tratamento depende da gravidade dos sintomas, do desejo reprodutivo da paciente e de outros fatores individuais. O acompanhamento regular com profissionais de saúde especializados é fundamental para uma gestão eficaz e personalizada da endometriose. Esta revisão oferece uma visão abrangente sobre as diversas abordagens no tratamento da endometriose, destacando a importância de considerar não apenas a dimensão física, mas também os aspectos psicossociais para otimizar a qualidade de vida das pacientes

Evidência de que os ácidos β-hidroxibutirato e acetoacetato não causam estresse oxidativo em córtex cerebral de ratos jovens in vitro

O acúmulo dos corpos cetônicos (CC) acetoacetato (AcAc) e β-hidroxibutirato (BHB) ocorre durante ojejum e durante episódios de descompensação metabólica em desordens neurometabólicas hereditárias. O presenteestudo investigou o efeito in vitro do AcAc e do BHB sobre vários parâmetros de estresse oxidativo em córtexcerebral de ratos jovens. Nossos resultados demonstraram que o AcAc e o BHB não foram capazes de alteraros parâmetros testados. Concluindo, estes dados sugerem que o AcAc e o BHB não possuem propriedades antioxidantesou pró-oxidantes em córtex cerebral de ratos jovens.Palavras-chave: Corpos cetônicos, acetoacetato, β-hidroxibutirato, ratos, in vitro

Acquired enamel pellicle protects gastroesophageal reflux disease patients against erosive tooth wear

Abstract The objective of this study was to compare the protein profile of the acquired enamel pellicle (AEP) formed in vivo in patients with or without gastroesophageal reflux disease (GERD), and with or without erosive tooth wear (ETW). Twenty-four volunteers were divided into 3 groups: 1) GERD and ETW; 2) GERD without ETW; and 3) control (without GERD). The AEP formed 120 min after prophylaxis was collected from the lingual/palatal surfaces. The samples were subjected to mass spectrometry (nLC-ESI-MS/MS) and label-free quantification by Protein Lynx Global Service software. A total of 213 proteins were identified, or 119, 92 and 106 from each group, respectively. Group 2 showed a high number of phosphorylated and calcium-binding proteins. Twenty-three proteins were found in all the groups, including 14-3-3 protein zeta/delta and 1-phosphatidylinositol. Several intracellular proteins that join saliva after the exfoliation of oral mucosa cells might have the potential to bind hydroxyapatite, or participate in forming supramolecular aggregates that bind to precursor proteins in the AEP. Proteins might play a central role in protecting the dental surface against acid dissolution

Proceedings of the 8th Annual Conference on the Science of Dissemination and Implementation

A1 Introduction to the 8(th) Annual Conference on the Science of Dissemination and Implementation: Optimizing Personal and Population Health David Chambers, Lisa Simpson D1 Discussion forum: Population health D&I research Felicia Hill-Briggs D2 Discussion forum: Global health D&I research Gila Neta, Cynthia Vinson D3 Discussion forum: Precision medicine and D&I research David Chambers S1 Predictors of community therapists’ use of therapy techniques in a large public mental health system Rinad Beidas, Steven Marcus, Gregory Aarons, Kimberly Hoagwood, Sonja Schoenwald, Arthur Evans, Matthew Hurford, Ronnie Rubin, Trevor Hadley, Frances Barg, Lucia Walsh, Danielle Adams, David Mandell S2 Implementing brief cognitive behavioral therapy (CBT) in primary care: Clinicians' experiences from the field Lindsey Martin, Joseph Mignogna, Juliette Mott, Natalie Hundt, Michael Kauth, Mark Kunik, Aanand Naik, Jeffrey Cully S3 Clinician competence: Natural variation, factors affecting, and effect on patient outcomes Alan McGuire, Dominique White, Tom Bartholomew, John McGrew, Lauren Luther, Angie Rollins, Michelle Salyers S4 Exploring the multifaceted nature of sustainability in community-based prevention: A mixed-method approach Brittany Cooper, Angie Funaiole S5 Theory informed behavioral health integration in primary care: Mixed methods evaluation of the implementation of routine depression and alcohol screening and assessment Julie Richards, Amy Lee, Gwen Lapham, Ryan Caldeiro, Paula Lozano, Tory Gildred, Carol Achtmeyer, Evette Ludman, Megan Addis, Larry Marx, Katharine Bradley S6 Enhancing the evidence for specialty mental health probation through a hybrid efficacy and implementation study Tonya VanDeinse, Amy Blank Wilson, Burgin Stacey, Byron Powell, Alicia Bunger, Gary Cuddeback S7 Personalizing evidence-based child mental health care within a fiscally mandated policy reform Miya Barnett, Nicole Stadnick, Lauren Brookman-Frazee, Anna Lau S8 Leveraging an existing resource for technical assistance: Community-based supervisors in public mental health Shannon Dorsey, Michael Pullmann S9 SBIRT implementation for adolescents in urban federally qualified health centers: Implementation outcomes Shannon Mitchell, Robert Schwartz, Arethusa Kirk, Kristi Dusek, Marla Oros, Colleen Hosler, Jan Gryczynski, Carolina Barbosa, Laura Dunlap, David Lounsbury, Kevin O'Grady, Barry Brown S10 PANEL: Tailoring Implementation Strategies to Context - Expert recommendations for tailoring strategies to context Laura Damschroder, Thomas Waltz, Byron Powell S11 PANEL: Tailoring Implementation Strategies to Context - Extreme facilitation: Helping challenged healthcare settings implement complex programs Mona Ritchie S12 PANEL: Tailoring Implementation Strategies to Context - Using menu-based choice tasks to obtain expert recommendations for implementing three high-priority practices in the VA Thomas Waltz S13 PANEL: The Use of Technology to Improve Efficient Monitoring of Implementation of Evidence-based Programs - Siri, rate my therapist: Using technology to automate fidelity ratings of motivational interviewing David Atkins, Zac E. Imel, Bo Xiao, Doğan Can, Panayiotis Georgiou, Shrikanth Narayanan S14 PANEL: The Use of Technology to Improve Efficient Monitoring of Implementation of Evidence-based Programs - Identifying indicators of implementation quality for computer-based ratings Cady Berkel, Carlos Gallo, Irwin Sandler, C. Hendricks Brown, Sharlene Wolchik, Anne Marie Mauricio S15 PANEL: The Use of Technology to Improve Efficient Monitoring of Implementation of Evidence-based Programs - Improving implementation of behavioral interventions by monitoring emotion in spoken speech Carlos Gallo, C. Hendricks Brown, Sanjay Mehrotra S16 Scorecards and dashboards to assure data quality of health management information system (HMIS) using R Dharmendra Chandurkar, Siddhartha Bora, Arup Das, Anand Tripathi, Niranjan Saggurti, Anita Raj S17 A big data approach for discovering and implementing patient safety insights Eric Hughes, Brian Jacobs, Eric Kirkendall S18 Improving the efficacy of a depression registry for use in a collaborative care model Danielle Loeb, Katy Trinkley, Michael Yang, Andrew Sprowell, Donald Nease S19 Measurement feedback systems as a strategy to support implementation of measurement-based care in behavioral health Aaron Lyon, Cara Lewis, Meredith Boyd, Abigail Melvin, Semret Nicodimos, Freda Liu, Nathanial Jungbluth S20 PANEL: Implementation Science and Learning Health Systems: Intersections and Commonalities - Common loop assay: Methods of supporting learning collaboratives Allen Flynn S21 PANEL: Implementation Science and Learning Health Systems: Intersections and Commonalities - Innovating audit and feedback using message tailoring models for learning health systems Zach Landis-Lewis S22 PANEL: Implementation Science and Learning Health Systems: Intersections and Commonalities - Implementation science and learning health systems: Connecting the dots Anne Sales S23 Facilitation activities of Critical Access Hospitals during TeamSTEPPS implementation Jure Baloh, Marcia Ward, Xi Zhu S24 Organizational and social context of federally qualified health centers and variation in maternal depression outcomes Ian Bennett, Jurgen Unutzer, Johnny Mao, Enola Proctor, Mindy Vredevoogd, Ya-Fen Chan, Nathaniel Williams, Phillip Green S25 Decision support to enhance treatment of hospitalized smokers: A randomized trial Steven Bernstein, June-Marie Rosner, Michelle DeWitt, Jeanette Tetrault, James Dziura, Allen Hsiao, Scott Sussman, Patrick O’Connor, Benjamin Toll S26 PANEL: Developing Sustainable Strategies for the Implementation of Patient-Centered Care across Diverse US Healthcare Systems - A patient-centered approach to successful community transition after catastrophic injury Michael Jones, Julie Gassaway S27 PANEL: Developing Sustainable Strategies for the Implementation of Patient-Centered Care across Diverse US Healthcare Systems - Conducting PCOR to integrate mental health and cancer screening services in primary care Jonathan Tobin S28 PANEL: Developing Sustainable Strategies for the Implementation of Patient-Centered Care across Diverse US Healthcare Systems - A comparative effectiveness trial of optimal patient-centered care for US trauma care systems Douglas Zatzick S29 Preferences for in-person communication among patients in a multi-center randomized study of in-person versus telephone communication of genetic test results for cancer susceptibility Angela R Bradbury, Linda Patrick-Miller, Brian Egleston, Olufunmilayo I Olopade, Michael J Hall, Mary B Daly, Linda Fleisher, Generosa Grana, Pamela Ganschow, Dominique Fetzer, Amanda Brandt, Dana Farengo-Clark, Andrea Forman, Rikki S Gaber, Cassandra Gulden, Janice Horte, Jessica Long, Rachelle Lorenz Chambers, Terra Lucas, Shreshtha Madaan, Kristin Mattie, Danielle McKenna, Susan Montgomery, Sarah Nielsen, Jacquelyn Powers, Kim Rainey, Christina Rybak, Michelle Savage, Christina Seelaus, Jessica Stoll, Jill Stopfer, Shirley Yao and Susan Domchek S30 Working towards de-implementation: A mixed methods study in breast cancer surveillance care Erin Hahn, Corrine Munoz-Plaza, Jianjin Wang, Jazmine Garcia Delgadillo, Brian Mittman Michael Gould S31Integrating evidence-based practices for increasing cancer screenings in safety-net primary care systems: A multiple case study using the consolidated framework for implementation research Shuting (Lily) Liang, Michelle C. Kegler, Megan Cotter, Emily Phillips, April Hermstad, Rentonia Morton, Derrick Beasley, Jeremy Martinez, Kara Riehman S32 Observations from implementing an mHealth intervention in an FQHC David Gustafson, Lisa Marsch, Louise Mares, Andrew Quanbeck, Fiona McTavish, Helene McDowell, Randall Brown, Chantelle Thomas, Joseph Glass, Joseph Isham, Dhavan Shah S33 A multicomponent intervention to improve primary care provider adherence to chronic opioid therapy guidelines and reduce opioid misuse: A cluster randomized controlled trial protocol Jane Liebschutz, Karen Lasser S34 Implementing collaborative care for substance use disorders in primary care: Preliminary findings from the summit study Katherine Watkins, Allison Ober, Sarah Hunter, Karen Lamp, Brett Ewing S35 Sustaining a task-shifting strategy for blood pressure control in Ghana: A stakeholder analysis Juliet Iwelunmor, Joyce Gyamfi, Sarah Blackstone, Nana Kofi Quakyi, Jacob Plange-Rhule, Gbenga Ogedegbe S36 Contextual adaptation of the consolidated framework for implementation research (CFIR) in a tobacco cessation study in Vietnam Pritika Kumar, Nancy Van Devanter, Nam Nguyen, Linh Nguyen, Trang Nguyen, Nguyet Phuong, Donna Shelley S37 Evidence check: A knowledge brokering approach to systematic reviews for policy Sian Rudge S38 Using Evidence Synthesis to Strengthen Complex Health Systems in Low- and Middle-Income Countries Etienne Langlois S39 Does it matter: timeliness or accuracy of results? The choice of rapid reviews or systematic reviews to inform decision-making Andrea Tricco S40 Evaluation of the veterans choice program using lean six sigma at a VA medical center to identify benefits and overcome obstacles Sherry Ball, Anne Lambert-Kerzner, Christine Sulc, Carol Simmons, Jeneen Shell-Boyd, Taryn Oestreich, Ashley O'Connor, Emily Neely, Marina McCreight, Amy Labebue, Doreen DiFiore, Diana Brostow, P. Michael Ho, David Aron S41 The influence of local context on multi-stakeholder alliance quality improvement activities: A multiple case study Jillian Harvey, Megan McHugh, Dennis Scanlon S42 Increasing physical activity in early care and education: Sustainability via active garden education (SAGE) Rebecca Lee, Erica Soltero, Nathan Parker, Lorna McNeill, Tracey Ledoux S43 Marking a decade of policy implementation: The successes and continuing challenges of a provincial school food and nutrition policy in Canada Jessie-Lee McIsaac, Kate MacLeod, Nicole Ata, Sherry Jarvis, Sara Kirk S44 Use of research evidence among state legislators who prioritize mental health and substance abuse issues Jonathan Purtle, Elizabeth Dodson, Ross Brownson S45 PANEL: Effectiveness-Implementation Hybrid Designs: Clarifications, Refinements, and Additional Guidance Based on a Systematic Review and Reports from the Field - Hybrid type 1 designs Brian Mittman, Geoffrey Curran S46 PANEL: Effectiveness-Implementation Hybrid Designs: Clarifications, Refinements, and Additional Guidance Based on a Systematic Review and Reports from the Field - Hybrid type 2 designs Geoffrey Curran S47 PANEL: Effectiveness-Implementation Hybrid Designs: Clarifications, Refinements, and Additional Guidance Based on a Systematic Review and Reports from the Field - Hybrid type 3 designs Jeffrey Pyne S48 Linking team level implementation leadership and implementation climate to individual level attitudes, behaviors, and implementation outcomes Gregory Aarons, Mark Ehrhart, Elisa Torres S49 Pinpointing the specific elements of local context that matter most to implementation outcomes: Findings from qualitative comparative analysis in the RE-inspire study of VA acute stroke care Edward Miech S50 The GO score: A new context-sensitive instrument to measure group organization level for providing and improving care Edward Miech S51 A research network approach for boosting implementation and improvement Kathleen Stevens, I.S.R.N. Steering Council S52 PANEL: Qualitative methods in D&I Research: Value, rigor and challenge - The value of qualitative methods in implementation research Alison Hamilton S53 PANEL: Qualitative methods in D&I Research: Value, rigor and challenge - Learning evaluation: The role of qualitative methods in dissemination and implementation research Deborah Cohen S54 PANEL: Qualitative methods in D&I Research: Value, rigor and challenge - Qualitative methods in D&I research Deborah Padgett S55 PANEL: Maps & models: The promise of network science for clinical D&I - Hospital network of sharing patients with acute and chronic diseases in California Alexandra Morshed S56 PANEL: Maps & models: The promise of network science for clinical D&I - The use of social network analysis to identify dissemination targets and enhance D&I research study recruitment for pre-exposure prophylaxis for HIV (PrEP) among men who have sex with men Rupa Patel S57 PANEL: Maps & models: The promise of network science for clinical D&I - Network and organizational factors related to the adoption of patient navigation services among rural breast cancer care providers Beth Prusaczyk S58 A theory of de-implementation based on the theory of healthcare professionals’ behavior and intention (THPBI) and the becker model of unlearning David C. Aron, Divya Gupta, Sherry Ball S59 Observation of registered dietitian nutritionist-patient encounters by dietetic interns highlights low awareness and implementation of evidence-based nutrition practice guidelines Rosa Hand, Jenica Abram, Taylor Wolfram S60 Program sustainability action planning: Building capacity for program sustainability using the program sustainability assessment tool Molly Hastings, Sarah Moreland-Russell S61 A review of D&I study designs in published study protocols Rachel Tabak, Alex Ramsey, Ana Baumann, Emily Kryzer, Katherine Montgomery, Ericka Lewis, Margaret Padek, Byron Powell, Ross Brownson S62 PANEL: Geographic variation in the implementation of public health services: Economic, organizational, and network determinants - Model simulation techniques to estimate the cost of implementing foundational public health services Cezar Brian Mamaril, Glen Mays, Keith Branham, Lava Timsina S63 PANEL: Geographic variation in the implementation of public health services: Economic, organizational, and network determinants - Inter-organizational network effects on the implementation of public health services Glen Mays, Rachel Hogg S64 PANEL: Building capacity for implementation and dissemination of the communities that care prevention system at scale to promote evidence-based practices in behavioral health - Implementation fidelity, coalition functioning, and community prevention system transformation using communities that care Abigail Fagan, Valerie Shapiro, Eric Brown S65 PANEL: Building capacity for implementation and dissemination of the communities that care prevention system at scale to promote evidence-based practices in behavioral health - Expanding capacity for implementation of communities that care at scale using a web-based, video-assisted training system Kevin Haggerty, David Hawkins S66 PANEL: Building capacity for implementation and dissemination of the communities that care prevention system at scale to promote evidence-based practices in behavioral health - Effects of communities that care on reducing youth behavioral health problems Sabrina Oesterle, David Hawkins, Richard Catalano S68 When interventions end: the dynamics of intervention de-adoption and replacement Virginia McKay, M. Margaret Dolcini, Lee Hoffer S69 Results from next-d: can a disease specific health plan reduce incident diabetes development among a national sample of working-age adults with pre-diabetes? Tannaz Moin, Jinnan Li, O. Kenrik Duru, Susan Ettner, Norman Turk, Charles Chan, Abigail Keckhafer, Robert Luchs, Sam Ho, Carol Mangione S70 Implementing smoking cessation interventions in primary care settings (STOP): using the interactive systems framework Peter Selby, Laurie Zawertailo, Nadia Minian, Dolly Balliunas, Rosa Dragonetti, Sarwar Hussain, Julia Lecce S71 Testing the Getting To Outcomes implementation support intervention in prevention-oriented, community-based settings Matthew Chinman, Joie Acosta, Patricia Ebener, Patrick S Malone, Mary Slaughter S72 Examining the reach of a multi-component farmers’ market implementation approach among low-income consumers in an urban context Darcy Freedman, Susan Flocke, Eunlye Lee, Kristen Matlack, Erika Trapl, Punam Ohri-Vachaspati, Morgan Taggart, Elaine Borawski S73 Increasing implementation of evidence-based health promotion practices at large workplaces: The CEOs Challenge Amanda Parrish, Jeffrey Harris, Marlana Kohn, Kristen Hammerback, Becca McMillan, Peggy Hannon S74 A qualitative assessment of barriers to nutrition promotion and obesity prevention in childcare Taren Swindle, Geoffrey Curran, Leanne Whiteside-Mansell, Wendy Ward S75 Documenting institutionalization of a health communication intervention in African American churches Cheryl Holt, Sheri Lou Santos, Erin Tagai, Mary Ann Scheirer, Roxanne Carter, Janice Bowie, Muhiuddin Haider, Jimmie Slade, Min Qi Wang S76 Reduction in hospital utilization by underserved patients through use of a community-medical home Andrew Masica, Gerald Ogola, Candice Berryman, Kathleen Richter S77 Sustainability of evidence-based lay health advisor programs in African American communities: A mixed methods investigation of the National Witness Project Rachel Shelton, Lina Jandorf, Deborah Erwin S78 Predicting the long-term uninsured population and analyzing their gaps in physical access to healthcare in South Carolina Khoa Truong S79 Using an evidence-based parenting intervention in churches to prevent behavioral problems among Filipino youth: A randomized pilot study Joyce R. Javier, Dean Coffey, Sheree M. Schrager, Lawrence Palinkas, Jeanne Miranda S80 Sustainability of elementary school-based health centers in three health-disparate southern communities Veda Johnson, Valerie Hutcherson, Ruth Ellis S81 Childhood obesity prevention partnership in Louisville: creative opportunities to engage families in a multifaceted approach to obesity prevention Anna Kharmats, Sandra Marshall-King, Monica LaPradd, Fannie Fonseca-Becker S82 Improvements in cervical cancer prevention found after implementation of evidence-based Latina prevention care management program Deanna Kepka, Julia Bodson, Echo Warner, Brynn Fowler S83 The OneFlorida data trust: Achieving health equity through research & training capacity building Elizabeth Shenkman, William Hogan, Folakami Odedina, Jessica De Leon, Monica Hooper, Olveen Carrasquillo, Renee Reams, Myra Hurt, Steven Smith, Jose Szapocznik, David Nelson, Prabir Mandal S84 Disseminating and sustaining medical-legal partnerships: Shared value and social return on investment James Teufe

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2