D-mixing and indirect CP violation measurements at LHCb

The LHCb experiment collected during run I the world's largest sample of charmed hadrons. This sample is used to search for CP violation in charm and for the measurements of D0 mixing parameters. The measurement of the D0 to D0bar mixing parameters and the search for indirect CP-violation in two-body charm decays at LHCb experiment are presented.Comment: Proceedings of the 8th International Workshop on the CKM Unitarity Triangle (CKM 2014), Vienna, Austria, September 8-12, 201

Indirect CP violation results and HFAG averages

The current status of the search for indirect CP violation in the neutral D meson system at the B-factories and at LHCb is reported. The indirect CP asymmetry search is performed by the measurement of the proper-time asymmetry ($A_{\Gamma}$) in decays of $D^0-\bar{D^0}$ mesons to CP eigenstates, $K^-K^+$ and $\pi^- \pi^+$, and by $y_{CP}$, the ratio between the effective lifetime measured in decay to a CP eigenstate and that to the mixed eigenstate $K \pi$. All results are consistent with the no CP violation hypothesis. The latest world averages for mixing and CP asymmetry in the charm sector evaluated by the Heavy Flavour Averaging Group are presented. The no mixing hypothesis is excluded at more than 12 standard deviations. The search for direct and indirect CP violation in the charm sector is consistent with no CP violation at 2.0% confident level.Comment: to appear in the proceedings of The 6th International Workshop on Charm Physics (CHARM 2013

Micro‐PIXE determination of Zr in rutile: an application to geothermometry of high‐P rocks from the western Alps (Italy)

AbstractThe Western Alps of Northern Italy mostly consist of lithotectonic units which re‐crystallised and were metamorphosed at high depth in a subduction zone. During their exhumation to shallow crustal levels, however, the high‐pressure (high‐P) mineral assemblages were pervasively re‐equilibrated under low‐pressure (low‐P) conditions, making difficult to estimate the metamorphic thermal peak.Rutile [TiO2] is a typical high‐P mineral, occurring as relict phase in low‐P re‐equilibrated metamorphic rocks. Recent studies suggest that, in thermodynamic systems buffered by the occurrence of quartz and zircon in the rock, Zr content in rutile is a temperature–dependent function that can be modelled quantitatively.An application of rutile Zr‐geothermometer to continental and oceanic rocks of the Western Alps, pervasively re‐equilibrated under low‐P conditions, is presented.The selected rutile crystals were analysed by PIXE using a microbeam set‐up at the LABEC laboratory of INFN in Florence. The PIXE spectra and maps were processed by Geopixe software package. Micro‐PIXE analyses allowed determining the concentration and the distribution of Zr.Results obtained by applying the rutile Zr‐geothermometer gave a more precise indication about the temperatures of the metamorphic conditions suffered by Alpine metamorphic rocks with respect to phase relations and conventional geothermometry, showing that determination of Zr concentration by micro‐PIXE technique is a useful tool to reconstruct metamorphic events.The continental units, outcropping in separate zones of Western Alps, show two slightly different thermal peaks (Tmean = 530 ± 10 °C and Tmean = 555 ± 10 °C) for the same metamorphic event. The oceanic units provide Tmean estimates of 575 ± 10 °C slightly higher than the continental units. Copyright © 2008 John Wiley & Sons, Ltd

Circulating Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and Arterial Stiffness in a Large Population Sample: Data From the Brisighella Heart Study

Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulating levels are significantly associated with an increased risk of cardiovascular events. This study aimed to evaluate the relationship between circulating levels of PCSK9 and arterial stiffness, an early instrumental biomarker of cardiovascular disease risk, in a large sample of overall healthy participants

Status and perspectives of the CAST experiment

Arık, Metin (Dogus Author) -- The conference paper was firstly submitted to 12th International Conference on Topics in Astroparticle and Underground Physics.The CERN Axion Solar Telescope (CAST) is currently the most sensitive axion helioscope designed to search for axions produced by the Primakoff process in the solar core. CAST is using a Large Hadron Collider (LHC) test magnet where axions could be converted into X-rays with energies up to 10 keV. During the phase I, the experiment operated with vacuum inside the magnet bores and covered axion masses up to 0.02 eV. In the phase II, the magnet bores were filled with a buffer gas (first 4He and later 3He) at various densities in order to extend the sensitivity to higher axion masses (up to f .18 eV). The phase II data taking was completed in 2011. So far, no evidence of axion signal has been found and CAST set the most restrictive experimental limit on the axion-photon coupling constant over a broad range of axion masses. The latest CAST results with 3He data in the mass range 0.39 eV < m a < 0.64 eV will be presented

Synthesis of Amphiphilic Hydantoin-based Universal Peptidomimetics as Antibiotic Agents

Three model hydantoin-based universal peptidomimetics are designed and synthetized. Their preferred amphiphilic -turn conformation was assessed by molecular modeling and NMR experiments, and their antibacterial acivity tasted against Gram positive and Gram negative bacteria strains, demostrating that these compounds could be a captivating class of antibiotic to fight emergent drug resistanc

Management of pregnancy-related hypertensive disorders in patients infected with SARS CoV-2: pharmacological and clinical issues

Aims: Coronavirus-19 infection (COVID-19) continues to spread throughout the world. It is known that among patients with hypertension, diabetes, chronic respiratory disease, or cardiovascular (CV) diseases, COVID-19 is associated with greater morbidity and mortality compared to patients without these conditions. This correlation is of great importance in pregnant women affected by COVID-19 since it usually leads to the development of a serious clinical complication. In particular, managing hypertensive disorders in pregnancy can be problematic because anti-hypertensive medications may interact pharmacologically with drugs used to treat COVID-19. This review focuses on the safety of drug treatment for COVID-19 in pregnant women treated with anti-hypertensive medication. Methods and results: Several databases were searched to identify relevant literature. A few anti-hypertensive drugs and antithrombotic treatments are known for having a beneficial effect in the management of hypertension and hypertensive disorders in pregnancy. In this review, we focus on the expected drug-drug interactions with the experimental agents mostly used to treat COVID-19. Conclusions: The current indication for the management of hypertension-related disorders in pregnancy maintain their validity, while the risk of pharmacological interaction with the currently tested anti-SARS-CoV-2 medications is relatively low

Latest results and prospects of the CERN Axion Solar Telescope

Çetin, Serkant Ali (Dogus Author) -- Ezer, C. (Dogus Author) -- Yıldız, Süleyman Cenk (Dogus Author)The CERN Axion Solar Telescope (CAST) experiment searches for axions from the Sun converted into few keV photons via the inverse Primakoff effect in the high magnetic field of a superconducting Large Hadron Collider (LHC) decommissioned test magnet. After results obtained with vacuum in the magnet pipes (phase I of the experiment) as well as with 4He the collaboration is now immersed in the data taking with 3He, to be finished in 2011. The status of the experiment will be presented, including a preliminary exclusion plot of the first 3He data. CAST is currently sensitive to realistic QCD axion models at the sub-eV scale, and with axion-photon couplings down to the ∼ 2 × 10-10 GeV -1, compatible with solar life limits. Future plans include revisiting vaccuum and 4He configurations with improved sensitivity, as well as possible additional search for non-standard signals from chamaleons, paraphotons or other WISPs. For the longer term, we study the feasibility of an altogether improved version of the axion helioscope concept, with a jump in sensitivity of about one order of magnitude in gaγ beyond CAST

Towards a radiation free numerical modelling framework to predict spring assisted correction of scaphocephaly

Sagittal Craniosynostosis (SC) is a congenital craniofacial malformation, involving premature sagittal suture ossification; spring-assisted cranioplasty (SAC) – insertion of metallic distractors for skull reshaping – is an established method for treating SC. Surgical outcomes are predictable using numerical modelling, however published methods rely on computed tomography (CT) scans availability, which are not routinely performed. We investigated a simplified method, based on radiation-free 3D stereophotogrammetry scans.Eight SAC patients (age 5.1 ± 0.4 months) with preoperative CT and 3D stereophotogrammetry scans were included. Information on osteotomies, spring model and post-operative spring opening were recorded. For each patient, two preoperative models (PREOP) were created: i) CT model and ii) S model, created by processing patient specific 3D surface scans using population averaged skin and skull thickness and suture locations. Each model was imported into ANSYS Mechanical (Analysis System Inc., Canonsburg, PA) to simulate spring expansion. Spring expansion and cranial index (CI - skull width over length) at times equivalent to immediate postop (POSTOP) and follow up (FU) were extracted and compared with in-vivo measurements.Overall expansion patterns were very similar for the 2 models at both POSTOP and FU. Both models had comparable outcomes when predicting spring expansion. Spring induced CI increase was similar, with a difference of 1.2%±0.8% for POSTOP and 1.6%±0.6% for FU.This work shows that a simplified model created from the head surface shape yields acceptable results in terms of spring expansion prediction. Further modelling refinements will allow the use of this predictive tool during preoperative planning