25 research outputs found
Clinic and pathological profile of the patients with pyoderma gangrenosum at Hospital de ClĂnicas de Porto Alegre (RS) - Brazil (2000-2006)
FUNDAMENTOS – O pioderma gangrenoso Ă© doença neutrofĂlica pouco freqĂĽente. Caracteriza-se por lesões cutâneas ulceradas, dolorosas, com bordas subminadas e violáceas. Os membros inferiores configuram o local mais acometido. Sua etiologia Ă© incerta, mas em 50% dos casos encontra-se associação com outras doenças. A histopatologia Ă© inespecĂfica, e o diagnĂłstico, essencialmente clĂnico. OBJETIVO – Avaliar o perfil clinicopatolĂłgico de pacientes com pioderma gangrenoso. MÉTODO – Estudo retrospectivo dos pacientes diagnosticados no perĂodo de 2000 a 2006 no Serviço de Dermatologia do Hospital de ClĂnicas de Porto Alegre. RESULTADOS – Foram observados 16 pacientes cuja idade mĂ©dia foi 49 anos, com predomĂnio do sexo feminino (62,5%). O perĂodo mĂ©dio entre inĂcio da doença e diagnĂłstico foi de 1,6 ano. A forma clĂnica predominante foi a ulcerativa (81,25%), e 87,5% das lesões localizavam-se nos membros inferiores. O sintoma mais freqĂĽentemente associado foi dor local (37,5%). Doze pacientes (66%) apresentaram doenças sistĂŞmicas concomitantes. Doença de Crohn, diabetes e colagenoses foram as principais comorbidades encontradas. O tratamento mais utilizado foi a corticoterapia sistĂŞmica, associada ou nĂŁo a outros medicamentos (50%), tendo 43,75% dos pacientes apresentado recidiva do quadro. CONCLUSĂ•ES – Os dados avaliados condizem com os encontrados na literatura. As doenças associadas mais prevalentes foram ileĂte regional, diabetes melitus e afecções do tecido conectivo. O tratamento mais utilizado incluiu corticoterapia sistĂŞmica. A maioria dos pacientes apresentou cicatrização completa , porĂ©m o nĂşmero de recidivas foi elevado.BACKGROUND - Pyoderma gangrenosum is an infrequent neutrophilic dermatosis. It presents more frequently with painful cutaneous ulcers, with undermined violaceous borders. The legs are most commonly affected. Etiology is uncertain, although there is an association with other diseases in 50% of the cases,. Histopathology is non-specific and diagnosis is mostly clinical. OBJECTIVE - To evaluate the clinical and pathological profile of a sample of patients with pyoderma gangrenosum. METHOD - This was a retrospective study performed with the patients diagnosed in the period between 2000 and 2006 at the Service of Dermatology of Hospital de ClĂnicas de Porto Alegre. RESULTS - Sixteen patients were considered. Average age was 49 years and women predominated (62.5%). The average period between the beginning of the illness and the diagnosis was 1.6 years. The most prevalent clinical form was the ulcerative (81.25%), and 87.5% of the lesions were on the legs. The most frequent symptom was local pain (37.5%). Crohn’s disease, diabetes, collagen diseases and leukemias were all found as co-morbidities. Treatment consisted of a systemic steroid, either alone or associated to other drugs; 43.75% had recurrence. CONCLUSIONS - The results were consistent with the literature. The most frequently associated diseasse were Crohn´s disease, diabetes and connective tissue diseases. Systemic steroids were the most used therapy modality. Most of the patients presented complete healing of the lesions. However, recurrence rate was high
Clinic and pathological profile of the patients with pyoderma gangrenosum at Hospital de ClĂnicas de Porto Alegre (RS) - Brazil (2000-2006)
FUNDAMENTOS – O pioderma gangrenoso Ă© doença neutrofĂlica pouco freqĂĽente. Caracteriza-se por lesões cutâneas ulceradas, dolorosas, com bordas subminadas e violáceas. Os membros inferiores configuram o local mais acometido. Sua etiologia Ă© incerta, mas em 50% dos casos encontra-se associação com outras doenças. A histopatologia Ă© inespecĂfica, e o diagnĂłstico, essencialmente clĂnico. OBJETIVO – Avaliar o perfil clinicopatolĂłgico de pacientes com pioderma gangrenoso. MÉTODO – Estudo retrospectivo dos pacientes diagnosticados no perĂodo de 2000 a 2006 no Serviço de Dermatologia do Hospital de ClĂnicas de Porto Alegre. RESULTADOS – Foram observados 16 pacientes cuja idade mĂ©dia foi 49 anos, com predomĂnio do sexo feminino (62,5%). O perĂodo mĂ©dio entre inĂcio da doença e diagnĂłstico foi de 1,6 ano. A forma clĂnica predominante foi a ulcerativa (81,25%), e 87,5% das lesões localizavam-se nos membros inferiores. O sintoma mais freqĂĽentemente associado foi dor local (37,5%). Doze pacientes (66%) apresentaram doenças sistĂŞmicas concomitantes. Doença de Crohn, diabetes e colagenoses foram as principais comorbidades encontradas. O tratamento mais utilizado foi a corticoterapia sistĂŞmica, associada ou nĂŁo a outros medicamentos (50%), tendo 43,75% dos pacientes apresentado recidiva do quadro. CONCLUSĂ•ES – Os dados avaliados condizem com os encontrados na literatura. As doenças associadas mais prevalentes foram ileĂte regional, diabetes melitus e afecções do tecido conectivo. O tratamento mais utilizado incluiu corticoterapia sistĂŞmica. A maioria dos pacientes apresentou cicatrização completa , porĂ©m o nĂşmero de recidivas foi elevado.BACKGROUND - Pyoderma gangrenosum is an infrequent neutrophilic dermatosis. It presents more frequently with painful cutaneous ulcers, with undermined violaceous borders. The legs are most commonly affected. Etiology is uncertain, although there is an association with other diseases in 50% of the cases,. Histopathology is non-specific and diagnosis is mostly clinical. OBJECTIVE - To evaluate the clinical and pathological profile of a sample of patients with pyoderma gangrenosum. METHOD - This was a retrospective study performed with the patients diagnosed in the period between 2000 and 2006 at the Service of Dermatology of Hospital de ClĂnicas de Porto Alegre. RESULTS - Sixteen patients were considered. Average age was 49 years and women predominated (62.5%). The average period between the beginning of the illness and the diagnosis was 1.6 years. The most prevalent clinical form was the ulcerative (81.25%), and 87.5% of the lesions were on the legs. The most frequent symptom was local pain (37.5%). Crohn’s disease, diabetes, collagen diseases and leukemias were all found as co-morbidities. Treatment consisted of a systemic steroid, either alone or associated to other drugs; 43.75% had recurrence. CONCLUSIONS - The results were consistent with the literature. The most frequently associated diseasse were Crohn´s disease, diabetes and connective tissue diseases. Systemic steroids were the most used therapy modality. Most of the patients presented complete healing of the lesions. However, recurrence rate was high
The role of K121Q ENPP1 polymorphism in diabetes mellitus and its complications
The aim of the present study was to analyze the frequency of K121Q polymorphism in the ENPP1 gene of Brazilian subjects according to ethnic origin and to determine its possible association with diabetes mellitus (DM) and/or diabetic complications. A cross-sectional study was conducted on 1027 type 2 DM patients and 240 anonymous blood donors (BD). Ethnicity was classified based on self-report of European and African descent. The Q allele frequency was increased in African descendant type 2 DM patients (KK = 25.9%, KQ = 48.2%, and QQ = 25.9%) and BD (KK = 22.0%, KQ = 53.8%, and QQ = 24.2%) compared to European descendant type 2 DM patients (KK = 62.7%, KQ = 33.3%, and QQ = 4.1%) and BD (KK = 61.0%, KQ = 35.6%, and QQ = 3.4%). However, there was no difference in genotype distribution or Q allele frequency between diabetic and non-diabetic subjects (European descendants: DM = 0.21 vs BD = 0.21, P = 0.966, and African descendants: DM = 0.50 vs BD = 0.51, P = 0.899). In addition, there were no differences in clinical, laboratory or insulin resistance indices among the three genotypes. The prevalence of DM complications was also similar. In conclusion, K121Q polymorphism is more common among Afro-Brazilian descendants regardless of glycemic status or insulin sensitivity indices. Likewise, insulin sensitivity and DM chronic complications appear not to be related to the polymorphism in this sample