Mapping Class Groups of Trigonal Loci

In this paper we study the topology of the stack $\mathcal{T}_g$ of smooth trigonal curves of genus g, over the complex field. We make use of a construction by the first named author and Vistoli, that describes $\mathcal{T}_g$ as a quotient stack of the complement of the discriminant. This allows us to use techniques developed by the second named author to give presentations of the orbifold fundamental group of $\mathcal{T}_g$, of its substrata with prescribed Maroni invariant and describe their relation with the mapping class group $\mathcal{M}ap_g$ of Riemann surfaces of genus g.Comment: To appear on Selecta Mat

Simplified Damper Cage Circuital Model and Fast Analytical–Numerical Approach for the Analysis of Synchronous Generators

The long and enduring history of utilization of the wound-field synchronous generator in a large number of applications makes it one of the most known and consolidated electrical machine technologies. Thus, its design, modeling, and analysis processes have been widely exploited and implemented through various and different methods, including the equivalent circuit approach. When a damper cage is embedded within the rotor of the synchronous generator, its theoretical analysis becomes quite complicated. Thus, today numerical tools are being used. In this paper, an alternative way of modeling symmetric damper cages of salient-pole synchronous generators is presented. The proposed approach is embedded in the circuital model of the generator. A hybrid analytical-numerical model is implemented, permitting to accurately predict the voltage waveforms of the generator with excellent accuracy, however, at a lower cost of computational resources than the pure numerical method. A case study of an off-the-shelf 400 kVA machine is considered to develop and validate the proposed technique. The results are compared with the corresponding finite-element and experimental evaluations for validation purposes

Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate

INTRODUCTION: Aging proteins undergo non-enzymatic post-translational modification, including isomerization and racemization. We hypothesized that cartilage with many long-lived components could accumulate non-enzymatically modified amino acids in the form of isomerized aspartate and that its liberation due to osteoarthritis (OA)-related cartilage degradation could reflect OA severity. METHODS: Articular cartilage and synovial fluid were obtained from 14 randomly selected total knee arthroplasty cases (56 to 79 years old) and non-arthritis cartilage from 8 trauma cases (51 to 83 years old). Paired lesional cartilage and non-lesioned OA cartilage were graded histologically using a modified Mankin system. Paired cartilage and synovial fluids were assayed for isomerized aspartate, phosphate-buffered saline/EDTA (ethylenediaminetetraacetic acid) extractable glycosaminoglycans, and total protein. Macroscopically normal non-lesioned OA cartilage was separated into superficial and deep regions when cartilage thickness was at least 3 mm (n = 6). RESULTS: Normalized to cartilage wet weight, normal cartilage and deep non-lesioned OA cartilage contained significantly (P < 0.05) more isomerized aspartate than superficial non-lesioned OA cartilage and lesioned cartilage. Synovial fluid isomerized aspartate correlated positively (R2 = 0.53, P = 0.02) and glycosaminoglycans correlated negatively (R2 = 0.42, P = 0.04) with histological OA lesion severity. Neither synovial fluid isomerized aspartate nor glycosaminoglycans nor total protein correlated with histological scores of non-lesioned areas. CONCLUSIONS: We show for the first time that human cartilage and synovial fluid contain measurable quantities of an isomerized amino acid and that synovial fluid concentrations of isomerized aspartate reflected severity of histological OA. Further assessment is warranted to identify the cartilage proteins containing this modification and to assess the functional consequences and biomarker applications of this analyte in OA

Economic evaluation of access to musculoskeletal care: The case of waiting for total knee arthroplasty

BACKGROUND: The projected demand for total knee arthroplasty is staggering. At its root, the solution involves increasing supply or decreasing demand. Other developed nations have used rationing and wait times to distribute this service. However, economic impact and cost-effectiveness of waiting for TKA is unknown. METHODS: A Markov decision model was constructed for a cost-utility analysis of three treatment strategies for end-stage knee osteoarthritis: 1) TKA without delay, 2) a waiting period with no non-operative treatment and 3) a non-operative treatment bridge during that waiting period in a cohort of 60 year-old patients. Outcome probabilities and effectiveness were derived from the literature. Costs were estimated from the societal perspective with national average Medicare reimbursement. Effectiveness was expressed in quality-adjusted life years (QALYs) gained. Principal outcome measures were average incremental costs, effectiveness, and quality-adjusted life years; and net health benefits. RESULTS: In the base case, a 2-year wait-time both with and without a non-operative treatment bridge resulted in a lower number of average QALYs gained (11.57 (no bridge) and 11.95 (bridge) vs. 12.14 (no delay). The average cost was $1,660 higher for TKA without delay than wait-time with no bridge, but$1,810 less than wait-time with non-operative bridge. The incremental cost-effectiveness ratio comparing wait-time with no bridge to TKA without delay was $2,901/QALY. When comparing TKA without delay to waiting with non-operative bridge, TKA without delay produced greater utility at a lower cost to society. CONCLUSIONS: TKA without delay is the preferred cost-effective treatment strategy when compared to a waiting for TKA without non-operative bridge. TKA without delay is cost saving when a non-operative bridge is used during the waiting period. As it is unlikely that patients waiting for TKA would not receive non-operative treatment, TKA without delay may be an overall cost-saving health care delivery strategy. Policies aimed at increasing the supply of TKA should be considered as savings exist that could indirectly fund those strategies

Organic Light-Emitting Transistors in a Smart-Integrated System for Plasmonic-Based Sensing

AbstractThe smart integration of multiple devices in a single functional unit is boosting the advent of compact optical sensors for on‐site analysis. Nevertheless, the development of miniaturized and cost‐effective plasmonic sensors is hampered by the strict angular constraints of the detection scheme, which are fulfilled through bulky optical components. Here, an ultracompact system for plasmonic‐sensing is demonstrated by the smart integration of an organic light‐emitting transistor (OLET), an organic photodiode (OPD), and a nanostructured plasmonic grating (NPG). The potential of OLETs, as planar multielectrode devices with inherent micrometer‐wide emission areas, offers the pioneer incorporation of an OPD onto the source electrode to obtain a monolithic photonic module endowed with light‐emitting and light‐detection characteristics at unprecedented lateral proximity of them. This approach enables the exploitation of the angle‐dependent sensing of the NPG in a miniaturized system based on low‐cost components, in which a reflective detection is enabled by the elegant fabrication of the NPG onto the encapsulation glass of the photonic module. The most effective layout of integration is unraveled by an advanced simulation tool, which allows obtaining an optics‐less plasmonic system able to perform a quantitative detection up to 10−2 RIU at a sensor size as low as 0.1 cm3

A Consequent-Pole Hybrid Exciter for Synchronous Generators

In low-to-medium power generating sets, a self powered brushless excitation system is typically employed. This solution is cost-effective, simple and compact, but it suffers from an unreliable voltage build-up at start-up, a slow dynamic response and a relatively low efficiency for the exciter. The push towards more effective, reliable and efficient products has recently led to consider excitation systems equipped with permanent magnet exciters and controlled rotating converters, but their diffusion is limited by their higher complexity and cost. This paper investigates the utilization of a hybrid excitation for the exciter, aiming to join the benefits of field windings and permanent magnets. As a case study, this concept is applied to a commercial mid-size generating set adopting an industrial perspective, aiming to maximize the benefits while minimizing the required modifications in the system design. After a preliminary analysis, a consequent-pole layout with surface-mounted bonded magnets is then selected as the most effective solution. Theoretical considerations, numerical analysis and experimental validation are reported to show that the hybrid excitation concept can actually lead to significant reduction of exciter field losses as well as to other appreciable side benefits with a very limited impact on the present design of the generating set

Static slicing of explicitly synchronized languages

Static analysis of concurrent languages is a complex task due to the non-deterministic execution of processes. If the concurrent language being studied allows process synchronization, then the analyses are even more complex (and thus expensive), e.g., due to the phenomenon of deadlock. In this work we introduce a static analysis technique based on program slicing for concurrent and explicitly synchronized languages in general, and CSP in particular. Concretely, given a particular point in a specification, our technique allows us to know what parts of the specification must necessarily be executed before this point, and what parts of the specification could be executed before it. Our technique is based on a new data structure that extends the Synchronized Control Flow Graph (SCFG). We show that this new data structure improves the SCFG by taking into account the context in which processes are called and, thus, it makes the slicing process more precise. The technique has been implemented and tested with real specifications, producing good results. After formally defining our technique, we describe our tool, its architecture, its main applications and the results obtained from several experiments conducted in order to measure the performance of the tool. © 2012 Elsevier Inc. All rights reserved.This work has been partially supported by the Spanish Ministerio de Economia y Competitividad (Secretaria de Estado de Investigacion, Desarrollo e Innovacion) under grant TIN2008-06622-C03-02 and by the Generalitat Valenciana under grant PROMETEO/2011/052. Salvador Tamarit was partially supported by the Spanish MICINN under FPI grant BES-2009-015019.Leuschel ., M.; Llorens Agost, ML.; Oliver Villarroya, J.; Silva Galiana, JF.; Tamarit Muñoz, S. (2012). Static slicing of explicitly synchronized languages. Information and Computation. 214:10-46. https://doi.org/10.1016/j.ic.2012.02.005S104621

“Micronuclei and Disease” special issue: Aims, scope, and synthesis of outcomes

[Abastract] The purpose of the “Micronuclei and Disease” special issue (SI) is to: (i) Determine the level of evidence for association of micronuclei (MN), a biomarker of numerical and structural chromosomal aberrations, with risk of specific diseases in humans; (ii) Define plausible mechanisms that explain association of MN with each disease; (iii) Identify knowledge gaps and research needed to translate MN assays into clinical practice. The “MN and Disease” SI includes 14 papers. The first is a review of mechanisms of MN formation and their consequences in humans. 11 papers are systematic reviews and/or meta-analyses of the association of MN with reproduction, child health, inflammation, auto-immune disease, glycation, metabolic diseases, chronic kidney disease, cardiovascular disease, eleven common cancers, ageing and frailty. The penultimate paper focuses on effect of interventions on MN frequency in the elderly. A road map for translation of MN data into clinical practice is the topic of the final paper. The majority of reviewed studies were case-control studies in which the ratio of mean MN frequency in disease cases relative to controls, i.e. the mean ratio (MR), was calculated. The mean of these MR values, estimated by meta-analyses, for lymphocyte and buccal cell MN in non-cancer diseases were 2.3 and 3.6 respectively, and for cancers they were 1.7 and 2.6 respectively. The highest MR values were observed in studies of cancer cases in which MN were measured in the same tissue as the tumour (MR = 4.9–10.8). This special issue is an important milestone in the evidence supporting MN as a reliable genomic biomarker of developmental and degenerative disease risk. These advances, together with results from prospective cohort studies, are helping to identify diseases in which MN assays can be practically employed in the clinical setting to better identify high risk patients and to prioritise them for preventive therapy

N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study

Our goal was the evaluation of a series of N-1,2,3-triazole-isatin derivatives for multi-target activity which included cholinesterase (ChE) inhibition and β-amyloid (Aβ) peptide anti-aggregation. The compounds have shown considerable promise as butyrylcholinesterase (BuChE) inhibitors. Although the inhibition of eel acet- ylcholinesterase (eeAChE) was weak, the inhibitions against equine BuChE (eqBuChE) and human BuChE (hBuChE) were more significant with a best inhibition against eqBuChE of 0.46 μM. In some cases, these mo- lecules gave better inhibitions for hBuChE than eqBuChE. For greater insights into their mode of action, mole- cular docking studies were carried out, followed by STD-NMR validation. In addition, some of these compounds showed weak Aβ anti-aggregation activity. Hepatotoxicity studies showed that they were non-hepatoxic and neurotoxicity studies using neurite out- growth experiments led to the conclusion that these compounds are only weakly neurotoxic

A methodology to remove stator skew in small-medium size synchronous generators via innovative damper cage designs

This paper proposes and investigates an innovative methodology that can have a significant impact on the market potential of wound field, small-medium size synchronous generators. The technique proposed here is aimed at removing the need for the traditional stator skewing that is so commonly used in synchronous generators to achieve acceptable values of voltage total harmonic distortion. To do this, a non-standard damper cage configuration is proposed that comprises modulation of the damper bars’ positioning. An off-the-shelf, 400kVA generator is used as a benchmark machine. Its rotor is optimized and modified according to the proposed technique. The results of the final machine are then compared to the benchmark machine highlighting the excellent advantages that can be achieved through this technique. A full-scale prototype of the modified generator is then built to experimentally validate the concept. Finally, a detailed analysis on all the performance aspects of the prototype is done, to guarantee that the proposed technique has no negative impact whatsoever on the generator’s performance