1,456 research outputs found
Probabilistic state preparation of a single molecular ion by projection measurement
We show how to prepare a single molecular ion in a specific internal quantum
state in a situation where the molecule is trapped and sympathetically cooled
by an atomic ion and where its internal degrees of freedom are initially in
thermal equilibrium with the surroundings. The scheme is based on conditional
creation of correlation between the internal state of the molecule and the
translational state of the collective motion of the two ions, followed by a
projection measurement of this collective mode by atomic ion shelving
techniques. State preparation in a large number of internal states is possible.Comment: 4 pages, 2 figures, 2 table
Distinct nature of static and dynamic magnetic stripes in cuprate superconductors
We present detailed neutron scattering studies of the static and dynamic
stripes in an optimally doped high-temperature superconductor,
LaCuO. We find that the dynamic stripes do not disperse towards the
static stripes in the limit of vanishing energy transfer. We conclude that the
dynamic stripes observed in neutron scattering experiments are not the
Goldstone modes associated with the broken symmetry of the simultaneously
observed static stripes, but rather that the signals originate from different
domains in the sample. These domains may be related by structural twinning, or
may be entirely different phases, where the static stripes in one phase are
pinned versions of the dynamic stripes in the other. Our results explain
earlier observations of unusual dispersions in underdoped
LaSrCuO () and LaBaCuO ().
Our findings are relevant for all compounds exhibiting magnetic stripes, and
may thus be a vital part in unveiling the nature of high temperature
superconductivity
Models and metaphors: complexity theory and through-life management in the built environment
Complexity thinking may have both modelling and metaphorical applications in the through-life management of the built environment. These two distinct approaches are examined and compared. In the first instance, some of the sources of complexity in the design, construction and maintenance of the built environment are identified. The metaphorical use of complexity in management thinking and its application in the built environment are briefly examined. This is followed by an exploration of modelling techniques relevant to built environment concerns. Non-linear and complex mathematical techniques such as fuzzy logic, cellular automata and attractors, may be applicable to their analysis. Existing software tools are identified and examples of successful built environment applications of complexity modelling are given. Some issues that arise include the definition of phenomena in a mathematically usable way, the functionality of available software and the possibility of going beyond representational modelling. Further questions arising from the application of complexity thinking are discussed, including the possibilities for confusion that arise from the use of metaphor. The metaphor of a 'commentary machine' is suggested as a possible way forward and it is suggested that an appropriate linguistic analysis can in certain situations reduce perceived complexity
A phylogenomic analysis of the role and timing of molecular adaptation in the aquatic transition of cetartiodactyl mammals
This work was funded by the European Research Council (ERC 1076 Starting grant no. 310482) awarded to S.J.R. and a Newton International Fellowship awarded to M.R.M
Imaging Neurodegenerative Metabolism in Amyotrophic Lateral Sclerosis with Hyperpolarized [1-13C]pyruvate MRI
The cause of amyotrophic lateral sclerosis (ALS) is still unknown, and consequently, early diagnosis of the disease can be difficult and effective treatment is lacking. The pathology of ALS seems to involve specific disturbances in carbohydrate metabolism, which may be diagnostic and therapeutic targets. Magnetic resonance imaging (MRI) with hyperpolarized [1-(13)C]pyruvate is emerging as a technology for the evaluation of pathway-specific changes in the brainâs metabolism. By imaging pyruvate and the lactate and bicarbonate it is metabolized into, the technology is sensitive to the metabolic changes of inflammation and mitochondrial dysfunction. In this study, we performed hyperpolarized MRI of a patient with newly diagnosed ALS. We found a lateralized difference in [1-(13)C]pyruvate-to-[1-(13)C]lactate exchange with no changes in exchange from [1-(13)C]pyruvate to (13)C-bicarbonate. The 40% increase in [1-(13)C]pyruvate-to-[1-(13)C]lactate exchange corresponded with the patientâs symptoms and presentation with upper-motor neuron affection and cortical hyperexcitability. The data presented here demonstrate the feasibility of performing hyperpolarized MRI in ALS. They indicate potential in pathway-specific imaging of dysfunctional carbohydrate metabolism in ALS, an enigmatic neurodegenerative disease
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