Alternative academic access - analising the success (part one)

Published ArticleThe contemporary challenge facing all Higher Education Institutions (HEI's) since 1994 focuses on generating methods to broaden the access for schoolleavers who are ill-prepared and not ready for higher education. In response to this challenge the CENTRAL UNIVERSITY OF TECHNOLOGY, FREE STATE'S SCHOOL FOR ENTREPRENEURSHIP AND BUSSINESS DEVELOPMENT (SEBD) developed and presented a foundation programme since 2001. This article is aimed at assessing its success. Although the success rate of the first intake was very low the author believes that by modifying the programme on a continuous basis, it has a justifiable place in the Institution's "access with success programme"

Occlusion-related lateral connections stabilize kinetic depth stimuli through perceptual coupling

Local sensory information is often ambiguous forcing the brain to integrate spatiotemporally separated information for stable conscious perception. Lateral connections between clusters of similarly tuned neurons in the visual cortex are a potential neural substrate for the coupling of spatially separated visual information. Ecological optics suggests that perceptual coupling of visual information is particularly beneficial in occlusion situations. Here we present a novel neural network model and a series of human psychophysical experiments that can together explain the perceptual coupling of kinetic depth stimuli with activity-driven lateral information sharing in the far depth plane. Our most striking finding is the perceptual coupling of an ambiguous kinetic depth cylinder with a coaxially presented and disparity defined cylinder backside, while a similar frontside fails to evoke coupling. Altogether, our findings are consistent with the idea that clusters of similarly tuned far depth neurons share spatially separated motion information in order to resolve local perceptual ambiguities. The classification of far depth in the facilitation mechanism results from a combination of absolute and relative depth that suggests a functional role of these lateral connections in the perception of partially occluded objects

Do digital information technologies help unemployed job seekers find a job? Evidence from the broadband internet expansion in Germany

This paper studies effects of the introduction of a new digital mass medium on reemployment of unemployed job seekers. We combine data on broadband internet availability at the local level with German individual register data. We address endogeneity by exploiting technological peculiarities that affected the roll-out of broadband internet. Results show that broadband internet improves reemployment rates after the first months in unemployment for males. Complementary analyses with survey data suggest that internet access mainly changes male job seekers' search behavior by increasing online search and the number of job applications. (C) 2021 Elsevier B.V. All rights reserved

Associations between BMI and the FTO Gene Are Age Dependent: Results from the GINI and LISA Birth Cohort Studies up to Age 6 Years

Objective: The association between polymorphisms in intron 1 of the fat mass and obesity associated gene (FTO) and obesity-related traits is one of the most robust associations reported for complex traits and is established both in adults and children. However, little is known about the longitudinal dynamics of these polymorphisms on body mass index (BMI), overweight, and obesity. Methods: This study is based on the 2,732 full-term neonates of the German GINI-plus and LISA-plus birth cohorts, for whom genotyping data on the FTO variants rs1558902 (T>A) or rs9935401 (G>A) were available. Children were followed from birth up to age 6 years. Up to 9 anthropometric measurements of BMI were obtained. Fractional-Polynomial-Generalized-Estimation-Equation modeling was used to assess developmental trends and their potential dependence on genotype status. Results: We observed no evidence for BMI differences between genotypes of both variants for the first 3 years of life. However, from age 3 years onwards, we noted a higher BMI for the homozygous minor alleles carriers in comparison to the other two genotype groups. However, evidence for statistical significance was reached from the age of 4 years onwards. Conclusions: This is one of the first studies investigating in detail the development of BMI depending on FTO genotype between birth and the age of 6 years in a birth cohort not selected for the phenotype studied. We observed that the association between BMI and FTO genotype evolves gradually and becomes descriptively detectable from the age of 3 years onwards

Thinking fast or slow? Functional magnetic resonance imaging reveals stronger connectivity when experienced neurologists diagnose ambiguous cases:Functional magnetic resonance imaging reveals stronger connectivity when experienced neurologists diagnose ambiguous cases

For almost 40 years, thinking about reasoning has been dominated by dual process theories. This model, consisting of two distinct types of human reasoning, one fast and effortless, the other slow and deliberate, has also been applied to medical diagnosis. Medical experts are trained to diagnose patients based on their symptoms. When symptoms are prototypical for a certain diagnosis, practitioners may rely on fast, recognition-based reasoning. However, if they are confronted with ambiguous clinical information slower, analytical reasoning is required. To examine the neural underpinnings of these two hypothesized forms of reasoning, sixteen highly experienced clinical neurologists were asked to diagnose two types of medical cases, straightforward and ambiguous cases, while functional magnetic resonance imaging was being recorded. Compared to reading control sentences, diagnosing cases resulted in increased activation in brain areas typically found to be active during reasoning such as the caudate nucleus, and frontal and parietal cortical regions. In addition, we found vast increased activity in the cerebellum. Regarding the activation differences between the two types of reasoning, no pronounced differences were observed in terms of regional activation. Notable differences were observed, though, in functional connectivity: cases containing ambiguous information showed stronger connectivity between specific regions in the frontal, parietal, and temporal cortex in addition to the cerebellum. Based on these results we propose that the higher demands in terms of controlled cognitive processing during analytical medical reasoning may be subserved by stronger communication between key regions for detecting and resolving uncertainty.<br/

Decadal shift in foraging strategy of a migratory southern ocean predator

Rapid anthropogenic environmental change is expected to impact a host of ecological parameters in Southern Ocean ecosystems. Of critical concern are the consequences of these changes on the range of species that show fidelity to migratory destinations, as philopatry is hypothesized to help or hinder adaptation to climate change depending on the circumstances. Many baleen whales show philopatry to feeding grounds and are also capital breeders that meet migratory and reproductive costs through seasonal energy intake. Southern right whales (Eubalaena australis, SRWs) are capital breeders that have a strong relationship between reproductive output and foraging success. The population dynamics of South Africa's population of SRWs are characterized by two distinct periods: the 1990s, a period of high calving rates; and the late 2010s, a period associated with lowered calving rates. Here we use analyses of stable carbon (δ13C) and nitrogen (δ15N) isotope values from SRW biopsy samples (n = 122) collected during these two distinct periods to investigate foraging ecology of the South African population of SRWs over a time period coincident with the demographic shift. We show that South African SRWs underwent a dramatic northward shift, and diversification, in foraging strategy from 1990s to 2010s. Bayesian mixing model results suggest that during the 1990s, South African SRWs foraged on prey isotopically similar to South Georgia/Islas Georgias del Sur krill. In contrast, in the 2010s, South African SRWs foraged on prey isotopically consistent with the waters of the Subtropical Convergence, Polar Front and Marion Island. We hypothesize that this shift represents a response to changes in preferred habitat or prey, for example, the decrease in abundance and southward range contraction of Antarctic krill. By linking reproductive decline to changing foraging strategies for the first time in SRWs, we show that altering foraging strategies may not be sufficient to adapt to a changing ocean

Uønskede effekter ved kjeveortopediske retainere. En systematisk litteraturoversikt og kliniske sjekkpunkter for allmenntannlegen

Kjeveortopedisk behandling med fast apparatur avløses gjerne av en retensjonsfase med uklar tidsbegrensning. Selv om limte retensjonstråder har en velbegrunnet hensikt i å motvirke uønsket residiv, er det grunn til å stille spørsmål ved oppfølging og mulige bivirkninger. Hovedmålet med denne systematiske oversikten var derfor å undersøke om faste kjeveortopediske retainere gir uønskede effekter og foreslå kliniske sjekkpunkter for allmenntannlegen. Et systematisk litteratursøk ble gjennomført etter fastsatte kriterier i databasene MEDLINE, Cochrane Library (inkludert Central), Embase, Web of Science og SveMed+. Nøkkelinformasjon ble presentert med utgangspunkt i PICO, mens kvalitative vurderinger ble gjennomført med tilpasset Newcastle-Ottawa scale og Cochrane’s Collaboration’s tool. Totalt 16 studier (13 kohortstudier, 3 randomiserte studier) møtte alle kriteriene for å bli inkludert. Etter bruk av retainere viste elleve studier periodontale utfall, med tendens til økt plakk-, gingvitt- og tannsteinsdannelse, tre studier påviste ulike biomarkører, og to studier uventede endringer i tannstilling. Klinikere bør være spesielt oppmerksomme på hygieneutfordringer og utilsiktet kraftpåvirkning ved faste retainere. Flere kvalitetsstudier med tilstrekkelig oppfølging er nødvendig. Tydelige, oppdaterte sjekklister er viktig for å håndtere komplikasjoner og sikre god rollefordelingen mellom tannlege og kjeveortoped.publishedVersio

A single center analysis of nucleophosmin in acute myeloid leukemia:value of combining immunohistochemistry with molecular mutation analysis

Mutations of nucleophosmin 1 are frequently found in acute myeloid leukemia and lead to aberrant cytoplasmic accumulation of nucleophosmin protein. Immunohistochemical staining is therefore recommended as the technique of choice in front-line screening. In this study, we assessed the sensitivity and specificity of immunohistochemistry on formalin-fixed bone marrow biopsies compared with gold standard molecular analysis to predict nucleophosmin 1 mutation status in 119 patients with acute myeloid leukemia. Discrepant cases were further characterized by gene expression analyses and fluorescence in situ hybridization. A large overlap between both methods was observed. Nevertheless, nine patients demonstrated discordant results at initial screening. Five cases demonstrated nuclear staining of nucleophosmin 1 by immunohistochemistry, but a nucleophosmin 1 mutation by molecular analysis. In two cases this could be attributed to technical issues and in three cases minor subpopulations of myeloblasts had not been discovered initially. All tested cases exhibited the characteristic nucleophosmin-mutated gene expression pattern. Four cases had cytoplasmic nucleophosmin 1 staining and a nucleophosmin-mutated gene expression pattern without a detectable nucleophosmin 1 mutation. In two of these cases we found the chromosomal translocation t(3;5)(q25;q35) encoding the NPM-MLF1 fusion protein. In the other discrepant cases the aberrant cytoplasmic nucleophosmin staining and gene expression could not be explained. In total six patients (5%) had true discordant results between immunohistochemistry and mutation analysis. We conclude that cytoplasmic nucleophosmin localization is not always caused by a conventional nucleophosmin 1 mutation and that in the screening for nucleophosmin 1 abnormalities, most information will be obtained by combining immunohistochemistry with molecular analysis

Editorial: Künstlerische Forschung an Hochschulen und Universitäten - zwischen Idee, Skizze und Realisierung

30.03.2015 | Doris Carstensen (Wien), Ulf Bästlein (Graz), Karen van den Berg (Friedrichshafen), Alexander Damianisch (Wien), Julie Harboe (Luzern), Bettina Henkel (Wien) & Andre Zogholy (Linz