CPCP violation in Bs0B_s^0 decays at LHCb

Latest LHCb measurements of $CP$ violation in the interference between mixing and decay are presented based on $pp$ collision data collected during LHC Run I, corresponding to an integrated luminosity of $3.0\, {\rm fb}^{-1}$. Approximately $27\, 000$ $B_s^0\to J/\psi \pi^+\pi^-$ signal events are used to make what is at the moment the most precise single measurement of the $CP$-violating phase in $b\to c\bar{c}s$ transitions, $\phi_s^{c\bar{c}s}=0.070\pm0.068{\rm (stat.)}\pm0.008{\rm (syst.)}$ rad. The most accurate measurement of the $CP$-violating phase in $b\to s\bar{s}s$ transitions, $\phi_s^{s\bar{s}s}$, is found from approximately $4\, 000$ $B_s^0\to \phi\phi$ signal events to be $\phi_s^{s\bar{s}s}=-0.17\pm{\rm (stat.)}0.15\pm0.03{\rm (syst.)}$ rad.Comment: 6 pages, 5 figures, presented at the second annual LHCP conferenc

Windmill Ridge Park: A Sustainable Park Design

This plan proposes designing and developing a new park in Chesterfield County that will promote sustainability in its design and implementation, as well as provide a stepping stone to promote these practices throughout Chesterfield County parks. This plan achieves this by providing research, concepts, and recommendations centered on the three Es of sustainability: environmental quality, social equity, and economic efficiency

Serum Ammonia and Folate Levels: Opportunities for High Value Care

High value care encompasses a variety of principles including ordering tests with high diagnostic yield, while reducing low value practice

Interoperable Credentials Management for Wholesale Banking

A gap exists between wholesale-banking business practices and security best practices: wholesale banks operate within the boundaries of contract law, while security best practices often relies upon a benevolent trusted party outside the scope of straightforward contracts. While some business domains may be able to bridge this gap, the ultra-high-value transactions used in business-to-business banking substantially increase the size of the gap. The gap becomes most apparent when regarded from the perspective of interoperability. If a single user applies the same credential to sign high-value transactions at multiple banks, then the trusted-party model becomes overly cumbersome and conflicts with an acceptable concept of liability. This paper outlines the business complexities of wholesale banking and proposes a solution called Partner Key Management (PKM). PKM technology manages the credentials required to authenticate users and sign transactions. This paper presents PKM technology by describing an interoperable protocol, requisite data structures, and an interoperable XML definition. The paper uses formal methods to demonstrate a security equivalence between revocation options within PKM against the security offered by the traditional Public Key Infrastructure (PKI), a technology that features the benevolent trusted party

Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution.

Elucidating the spectrum of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) states in clinical samples promises insights on cancer progression and drug resistance. Using mass cytometry time-course analysis, we resolve lung cancer EMT states through TGFβ-treatment and identify, through TGFβ-withdrawal, a distinct MET state. We demonstrate significant differences between EMT and MET trajectories using a computational tool (TRACER) for reconstructing trajectories between cell states. In addition, we construct a lung cancer reference map of EMT and MET states referred to as the EMT-MET PHENOtypic STAte MaP (PHENOSTAMP). Using a neural net algorithm, we project clinical samples onto the EMT-MET PHENOSTAMP to characterize their phenotypic profile with single-cell resolution in terms of our in vitro EMT-MET analysis. In summary, we provide a framework to phenotypically characterize clinical samples in the context of in vitro EMT-MET findings which could help assess clinical relevance of EMT in cancer in future studies

High School Students’ Learning During the COVID Pandemic: Perspectives from Health Sciences and Technology Academy Participants

This paper examines the perspectives of Health Sciences and Technology Academy (HSTA) participants as they navigate through their West Virginia (WV) high school learning environments (i.e., in-person, blended/hybrid, complete virtual) during the novel coronavirus, SARS-CoV-19 (COVID-19) pandemic. In March of 2020, the participants in this out-of-school-time (OST) academic enrichment program for exceptionally driven, yet underprivileged, at-risk students, with over 70% living in rural areas, started receiving remote learning instruction through learning management systems or via paper packets. In August of 2020, school systems provided parents and caregivers alternative learning environments for their student(s). In order to understand the learning experiences of HSTA students during these unprecedented times, HSTA released the 2020 Learning Outcomes Survey to participants in December of 2020. We performed chi-square test of independence to test the relationship between participants’ learning environments, their satisfaction with the education they were receiving, their ability to keep up with their school-work, teacher availability to help when needed and teacher feedback supporting them in their learning environment. The results show significant differences between the learning environments and keeping up with school-work as well as teacher feedback supporting them in their learning; however, Phi and Cramer’s V tests for effect size show weak correlations. This study provides a small glimpse into HSTA students’ learning experiences as they attempted to continue to learn in their regular school environment during the COVID-19 pandemic while in HSTA

Implications of the problem orientated medical record (POMR) for research using electronic GP databases: a comparison of the Doctors Independent Network Database (DIN) and the General Practice Research Database (GPRD).

Background The General Practice Research Database (GPRD) and Doctor's Independent Network Database (DIN), are large electronic primary care databases compiled in the UK during the 1990s. They provide a valuable resource for epidemiological and health services research. GPRD (based on VAMP) presents notes as a series of discrete episodes, whereas DIN is based on a system (MEDITEL) that used a Problem Orientated Medical Record (POMR) which links prescriptions to diagnostic problems. We have examined the implications for research of these different underlying philosophies. Methods Records of 40,183 children from 141 practices in DIN and 76,310 from 464 practices in GRPD who were followed to age 5 were used to compare the volume of recording of prescribing and diagnostic codes in the two databases. To assess the importance and additional value of the POMR within DIN, the appropriateness of diagnostic linking to skin emollient prescriptions was investigated. Results Variation between practices for both the number of days on which prescriptions were issued and diagnoses were recorded was marked in both databases. Mean number of "prescription days" during the first 5 years of life was similar in DIN (19.5) and in GPRD (19.8), but the average number of "diagnostic days" was lower in DIN (15.8) than in GPRD (22.9). Adjustment for linkage increased the average "diagnostic days" to 23.1 in DIN. 32.7% of emollient prescriptions in GPRD appeared with an eczema diagnosis on the same day compared to only 19.4% in DIN; however, 86.4% of prescriptions in DIN were linked to an earlier eczema diagnosis. More specifically 83% of emollient prescriptions appeared under a problem heading of eczema in the 121 practices that were using problem headings satisfactorily. Conclusion Prescribing records in DIN and GPRD are very similar, but the usage of diagnostic codes is more parsimonious in DIN because of its POMR structure. Period prevalence rates will be underestimated in DIN unless this structure is taken into account. The advantage of the POMR is that in 121 of 141 practices using problem headings as intended, most prescriptions can be linked to a problem heading providing a specific reason for their issue