Holding on to Clarity: Reconciling the Federal Kidnapping Statute with the Trafficking Victims Protection Act

In recent decades, the international community has come to recognize human trafficking as a problem of epidemic proportions. Congress responded to this global crisis in 2000 by passing the Trafficking Victims Protection Act (TVPA) and has since supplemented that comprehensive enactment. But, in light of the widespread use of psychological rather than physical coercion in trafficking cases, a long-standing split among federal courts regarding the scope of the federal kidnapping statute raises significant concerns about the United States’ efforts to combat traffickers. In particular, the broad interpretation adopted by several circuits threatens effective enforcement of statutes designed to prosecute traffickers, endangers the due process rights of potential defendants, and risks rendering the criminal provisions of the TVPA superfluous. This Note argues that those broader interpretations are incorrect as a matter of proper statutory interpretation, and especially when considered in light of the passage of the TVPA. It further contends that, in kidnapping-by-deception cases, the prosecution must demonstrate that the defendant intended to back up the deception with force or the threat of force if his ruse failed

Too Many Cooks in the Climate Change Kitchen: The Case for an Administrative Remedy for Damages Caused by Increased Greenhouse Gas Concentrations

Recent federal and state court decisions have made clear that federal common law claims against emitters of greenhouse gases are not sustainable; however, those same courts seem to have given state common law tort claims the green light, at least if the claims are brought in the state where the polluters are located. This Note contends that such suits are not an adequate remedy for those injured by climate change because they will face nearly insurmountable barriers in state court, and because there are major policy-level drawbacks to relying on state tort law rather than a federal solution. This Note then proposes a federal regulatory system of climate change compensation and explains several reasons why it is a preferable means of compensating climate change’s victims

Holding on to Clarity: Reconciling the Federal Kidnapping Statute with the Trafficking Victims Protection Act

In recent decades, the international community has come to recognize human trafficking as a problem of epidemic proportions. Congress responded to this global crisis in 2000 by passing the Trafficking Victims Protection Act (TVPA) and has since supplemented that comprehensive enactment. But, in light of the widespread use of psychological rather than physical coercion in trafficking cases, a long-standing split among federal courts regarding the scope of the federal kidnapping statute raises significant concerns about the United States’ efforts to combat traffickers. In particular, the broad interpretation adopted by several circuits threatens effective enforcement of statutes designed to prosecute traffickers, endangers the due process rights of potential defendants, and risks rendering the criminal provisions of the TVPA superfluous. This Note argues that those broader interpretations are incorrect as a matter of proper statutory interpretation, and especially when considered in light of the passage of the TVPA. It further contends that, in kidnapping-by-deception cases, the prosecution must demonstrate that the defendant intended to back up the deception with force or the threat of force if his ruse failed

Geometry of Pipe Dream Complexes

In this dissertation we study the geometry of pipe dream complexes with the goal of gaining a deeper understanding of Schubert polynomials. Given a pipe dream complex PD(w) for w a permutation in the symmetric group, we show its boundary is Whitney stratified by the set of all pipe dream complexes PD(v) where v \u3e w in the strong Bruhat order. For permutations w in the symmetric group on n elements, we introduce the pipe dream complex poset P(n). The dual of this graded poset naturally corresponds to the poset of strata associated to the Whitney stratification of the boundary of the pipe dream complex of the identity element. We examine pipe dream complexes in the case a permutation is a product of commuting adjacent transpositions. Finally, we consider pattern avoidance results. For 132-avoiding permutations, the Rothe diagram forms a Young diagram. In the case a permutation w has exactly one 132-pattern, the associated pipe dream complex is an m-dimensional simplex, where m = n choose 2 − l(w) − 1 and l(w) is the length of w. In the case of exactly two 132 patterns, there are three possible configurations. We include generalizations of these cases

Single Cell Biophysics: Applications in Cardiomyocyte Mechanobiology and Stem Cell Mechanotransduction

While a great deal of work has been done to analyze cardiac dynamics and mechanics at the organ and tissue levels, there remains much less data regarding these metrics at the single cell level. Additionally, as fields such as regenerative medicine and tissue engineering are beginning to demonstrate greater therapeutic potential, the study and influence of stem cell mechanics on differentiation has become a major area of interest. For these reasons, along with the continued advancement of molecular techniques and assays, there is a growing need to develop functional assays that can integrate and bridge the findings from multiple length scales, incorporating important physical cues with ongoing molecular studies. In this work, we have utilized various experimental techniques to quantify the altered mechanics and dynamics of individual cardiomyocytes and stem cells in association with various aspects of pathophysiology, toxin exposure, and stem cell differentiation. Through the completion of single cell studies, we have been able to draw significant insight and further relate various components of cellular mechanobiology, such as time-dependent mechanical cues and altered dynamics, with more physiologically relevant and translational research objectives. Although much more work is still needed, it is clear that this area of research has the potential to impact future studies in a variety of biomedical applications, opening up the possibilities of what can be accomplished with the use of single cell studies and the developing significance of cellular biophysics

From Random to Regular: Variation in the Patterning of Retinal Mosaics

The various types of retinal neurons are each positioned at their respective depths within the retina where they are believed to be assembled as orderly mosaics, in which like-type neurons minimize proximity to one another. Two common statistical analyses for assessing the spatial properties of retinal mosaics include the nearest neighbor analysis, from which an index of their "regularity" is commonly calculated, and the density recovery profile derived from auto-correlation analysis, revealing the presence of an exclusion zone indicative of anti-clustering. While each of the spatial statistics derived from these analyses, the regularity index and the effective radius, can be useful in characterizing such properties of orderly retinal mosaics, they are rarely sufficient for conveying the natural variation in the self-spacing behavior of different types of retinal neurons and the extent to which that behavior generates uniform intercellular spacing across the mosaic. We consider the strengths and limitations of different spatial statistical analyses for assessing the patterning in retinal mosaics, highlighting a number of misconceptions and their frequent misuse. Rather than being diagnostic criteria for determining simply whether a population is "regular", they should be treated as descriptive statistics that convey variation in the factors that influence neuronal positioning. We subsequently apply multiple spatial statistics to the analysis of eight different mosaics in the mouse retina, demonstrating conspicuous variability in the degree of patterning present, from essentially random to notably regular. This variability in patterning has both a developmental as well as a functional significance, reflecting the rules governing the positioning of different types of neurons as the architecture of the retina is assembled (abstract truncated).Comment: 11 Figure

Experimental Studies and Dynamics Modeling Analysis of the Swimming and Diving of Whirligig Beetles (Coleoptera: Gyrinidae)

Whirligig beetles (Coleoptera, Gyrinidae) can fly through the air, swiftly swim on the surface of water, and quickly dive across the air-water interface. The propulsive efficiency of the species is believed to be one of the highest measured for a thrust generating apparatus within the animal kingdom. The goals of this research were to understand the distinctive biological mechanisms that allow the beetles to swim and dive, while searching for potential bio-inspired robotics applications. Through static and dynamic measurements obtained using a combination of microscopy and high-speed imaging, parameters associated with the morphology and beating kinematics of the whirligig beetle\u27s legs in swimming and diving were obtained. Using data obtained from these experiments, dynamics models of both swimming and diving were developed. Through analysis of simulations conducted using these models it was possible to determine several key principles associated with the swimming and diving processes. First, we determined that curved swimming trajectories were more energy efficient than linear trajectories, which explains why they are more often observed in nature. Second, we concluded that the hind legs were able to propel the beetle farther than the middle legs, and also that the hind legs were able to generate a larger angular velocity than the middle legs. However, analysis of circular swimming trajectories showed that the middle legs were important in maintaining stable trajectories, and thus were necessary for steering. Finally, we discovered that in order for the beetle to transition from swimming to diving, the legs must change the plane in which they beat, which provides the force required to alter the tilt angle of the body necessary to break the surface tension of water. We have further examined how the principles learned from this study may be applied to the design of bio-inspired swimming/diving robots. DOI: 10.1371/journal.pcbi.100279

Vascular changes in diabetic retinopathy-a longitudinal study in the Nile rat.

Diabetic retinopathy is the most common microvascular complication of diabetes and is a major cause of blindness, but an understanding of the pathogenesis of the disease has been hampered by a lack of accurate animal models. Here, we explore the dynamics of retinal cellular changes in the Nile rat (Arvicanthis niloticus), a carbohydrate-sensitive model for type 2 diabetes. The early retinal changes in diabetic Nile rats included increased acellular capillaries and loss of pericytes that correlated linearly with the duration of diabetes. These vascular changes occurred in the presence of microglial infiltration but in the absence of retinal ganglion cell loss. After a prolonged duration of diabetes, the Nile rat also exhibits a spectrum of retinal lesions commonly seen in the human condition including vascular leakage, capillary non-perfusion, and neovascularization. Our longitudinal study documents a range and progression of retinal lesions in the diabetic Nile rat remarkably similar to those observed in human diabetic retinopathy, and suggests that this model will be valuable in identifying new therapeutic strategies

Rational Design of Superhydrophilic/Superoleophobic Surfaces for Oil-Water Separation via Thiol-Acrylate Photopolymerization

We report a simple, rapid, and scalable strategy to fabricate surfaces exhibiting in-air superoleophobic/superhydrophilic wetting via sequential spray deposition and photopolymerization of nanoparticle-laden thiol–acrylate resins comprising both hydrophilic and oleophobic chemical constituents. The combination of spray deposition with nanoparticles provides hierarchical surface morphologies with both micro- and nanoscale roughness. Mapping the wetting behavior as a function of resin composition using high- and low-surface-tension liquid probes enabled facile identification of coatings that exhibit a range of wetting behavior, including superhydrophilic/superoleophilic, superhydrophobic/superoleophobic, and in-air superhydrophilic/superoleophobic wetting. In-air superhydrophilic/superoleophobic wetting was realized by a dynamic rearrangement of the interface to expose a greater fraction of hydrophilic moieties in response to contact with water. We show that these in-air superoleophobic/superhydrophilic coatings deposited onto porous supports enable separation of model oil–water emulsions with separation efficiencies up to 99.9% with 699 L·m–2 h–1 permeate flux when the superhydrophilic/superoleophobic coatings are paired with 0.45 μm nylon membrane supports