Dnepropetrovsk hygienic school: past, present and future.

The article presents historical analysis of formation of hygiene school of Dnipropetrovsk Medical Academy over the 100 year period - from formation of Katerinoslav province sanitary district council, as a unique self-government social organization in XIX century to the present. The basic stages of its development, including foundation of Hygiene Courses at High Mining School, their transformation into department of general hygiene, social hygiene and hygiene of labor in Katerinoslav Medical Academy in 1922, foundation of separate departments of hygiene in 1940-1948, their reorganization at the end of  XX – beginning of XXI centuries are outlined. It is established, that Dnipropetrovsk hygiene school during its existence formed a great number of outstanding scientists, more than 100 dissertations in different directions devoted to hygienic diagnostics of technogenically changing environment, its impact on human health as well as hygienic control levers and health strengthening of population of industrial areas were defended. Scientific contribution of prominent scientists and teachers, their achievements and discoveries in the field of preventive medicine, role in the formation of preventive world outlook of students are estimated. At the XIV hygienic congress 30 hygienists were recognized as leading scientists of Ukraine over XX century, seven of them are from Dnipropetrovsk hygiene school; this indicates its importance in the noble cause of serving public health

High quality anti-relaxation coating material for alkali atom vapor cells

We present an experimental investigation of alkali atom vapor cells coated with a high quality anti-relaxation coating material based on alkenes. The prepared cells with single compound alkene based coating showed the longest spin relaxation times which have been measured up to now with room temperature vapor cells. Suggestions are made that chemical binding of a cesium atom and an alkene molecule by attack to the C=C bond plays a crucial role in such improvement of anti-relaxation coating quality

Біопротекторна дія цинку в макро- і наноаквахелатній формі на ембріогенез щурів за умови свинцевої інтоксикації

The article presents results of studied influence of low doses of lead and zinc (nanozinc) on embryonal development in a la­boratory experiment on rats.  Negative influence of lead on pregnancy of laboratory animals, manifested in violation of the physiological dynamics of the rectal temperature and decrease in body weight gain was revealed. Embryotoxic ef­fect of low doses of lead results in increased fetal mortality by 2.16 times compared to the control group of animals, de­terioration of the morphometric indices of fetuses, violation of placentogenesis. Simultaneous injections of zinc on back­ground of lead intoxication causes a protective effect on the body of pregnant rats and embryonal development of the offspring, more pronounced for zinc citrate, received by using aquananotehnology, as compared to zinc chloride. Thus, by morphometry indices, male fetuses were more sensitive to prenatal lead exposure in comparison to female fetuses.В статье представлены результаты изучения воздействия низких доз свинца и цинка (наноцинка) на эмбриональное развитие в условиях лабораторного эксперимента на крысах. Установлено негативное вли­яние свинца на протекание беременности у лабораторных животных, что проявляется в нарушении физио­логической динамики ректальной температуры и снижении прироста массы тела. Эмбриотоксический эффект низких доз свинца проявляется в увеличении эмбриональной смертности в 2,16 раза по сравнению с кон­трольной группой животных, ухудшении морфометрических показателей плодов, нарушении плацен­тогенеза. Одновременное введение препаратов цинка при свинцовой интоксикации оказывает протекторное действие на организм беременных крыс и эмбриональное развитие потомства, более выраженное для цит­рата цинка, полученного с использованием аквананотехнологии по сравнению с хлоридом цинка. При этом по морфометрическим показателям плоды мужского пола оказались более чувствительны к пренатальному воз­действию свинца по сравнению с плодами женского пола. The article presents results of studied influence of low doses of lead and zinc (nanozinc) on embryonal development in a la­boratory experiment on rats.  Negative influence of lead on pregnancy of laboratory animals, manifested in violation of the physiological dynamics of the rectal temperature and decrease in body weight gain was revealed. Embryotoxic ef­fect of low doses of lead results in increased fetal mortality by 2.16 times compared to the control group of animals, de­terioration of the morphometric indices of fetuses, violation of placentogenesis. Simultaneous injections of zinc on back­ground of lead intoxication causes a protective effect on the body of pregnant rats and embryonal development of the offspring, more pronounced for zinc citrate, received by using aquananotehnology, as compared to zinc chloride. Thus, by morphometry indices, male fetuses were more sensitive to prenatal lead exposure in comparison to female fetuses

Functionalized Poly(3-hexylthiophene)s via Lithium–Bromine Exchange

Poly(3-hexylthiophene) (P3HT) is one of the most extensively investigated conjugated polymers and has been employed as the active material in many devices including field-effect transistors, organic photovoltaics and sensors. As a result, methods to further tune the properties of P3HT are desirable for specific applications. Herein, we report a facile postpolymerization modification strategy to functionalize the 4-position of commercially available P3HT in two simple steps–bromination of the 4-position of P3HT (Br–P3HT) followed by lithium−bromine exchange and quenching with an electrophile. We achieved near quantitative lithium–bromine exchange with Br–P3HT, which requires over 100 thienyl lithiates to be present on a single polymer chain. The lithiated-P3HT is readily combined with functional electrophiles, resulting in P3HT derivatives with ketones, secondary alcohols, trimethylsilyl (TMS) group, fluorine, or an azide at the 4-position. We demonstrated that the azide-modified P3HT could undergo Cu-catalyzed or Cu-free click chemistry, significantly expanding the complexity of the structures that can be appended to P3HT using this method.National Science Foundation (U.S.) (ECCS-0939514

A Practical, One-Pot Synthesis of Highly Substituted Thiophenes and Benzo[b]thiophenes from Bromoenynes and o-Alkynylbromobenzenes

An efficient synthesis of thiophenes and benzo[b]thiophenes has been developed from easily available bromoenynes and o-alkynylbromobenzene derivatives. This novel one-pot procedure involves a Pd-catalyzed C–S bond formation using a hydrogen sulfide surrogate followed by a heterocyclization reaction. Moreover, in situ functionalization with selected electrophiles further expands the potential of this methodology to the preparation of the corresponding highly substituted sulfur heterocycles.Junta de Castilla y Leon (BU021A09 and GR-172) and Ministerio de Ciencia e Innovacion (MICINN) and FEDER (CTQ2010-15358 and CTQ2009-09949/BQU) for financial support. P.G.-G. and M.A.F.-R. thank MICINN for "Juan de la Cierva" and "Ramon y Cajal" contractsJunta de Castilla y Leon (BU021A09 and GR-172) and Ministerio de Ciencia e Innovacion (MICINN) and FEDER (CTQ2010-15358 and CTQ2009-09949/BQU) for financial support. P.G.-G. and M.A.F.-R. thank MICINN for "Juan de la Cierva" and "Ramon y Cajal" contractsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher

ТРАНСПЛАНТИРОВАННОЕ СЕРДЦЕ. ПРАВОЖЕЛУДОЧКОВАЯ НЕДОСТАТОЧНОСТЬ, ОТТОРЖЕНИЕ ИЛИ МИОКАРДИТ?

The differentiation of the cases of the right ventricular failure in transplanted heart should be complex and challenging. The 28-year old man with dilated cardiomyopathy underwent orthotopic heart transplantation. After transplantation developed right ventricular failure. The biopsy (n = 5) didn’t reveal any signs of myocardial rejection. There were noted some signs of inflammation in lateral right ventricular wall only by gated SPECT. The right ventricular failure increased and 6 months later there was successfully performed the heart retransplantation on the patient. The virusological study revealed the Epstein–Barr virus in myocardium. The explanted heart research excluded limphoproliferative disease by immunogystochemical tests. The final diagnosis is myocarditis. Дифференцирование причин правожелудочковой недостаточности пересаженного сердца должно быть комплексным. Мужчина 28 лет с дилатационной кардиомиопатией был подвергнут ортотопической трансплантации сердца. После трансплантации развилась прогрессирующая правожелудочковая недо- статочность. Биопсия (в количестве 5) не выявила признаков отторжения миокарда. Только при gated SPECT были отмечены признаки воспаления в боковой стенке ПЖ. Правожелудочковая недостаточность нарастала, и спустя 6 месяцев больному успешно была выполнена ретрансплантация сердца. Вирусоло- гическое исследование выявило наличие вируса Эпштейна–Барр в миокарде. Иммуногистохимические исследования эксплантированного сердца исключили лимфопролиферативное заболевание. Заключи- тельный диагноз – миокардит.